CNTF (156_198)(Mouse) _ 100ug
- Known as:
- CNTF (156_198)(Mouse) _ 100ug
- Catalog number:
- 002-91
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Phoenix Peptide
- Gene target:
- CNTF (156_198)(Mouse) _ 100ug
Related genes to: CNTF (156_198)(Mouse) _ 100ug
- Gene:
- CNTF NIH gene
- Name:
- ciliary neurotrophic factor
- Previous symbol:
- -
- Synonyms:
- HCNTF
- Chromosome:
- 11q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-01-07
- Date modifiied:
- 2016-10-05
Related products to: CNTF (156_198)(Mouse) _ 100ug
Related articles to: CNTF (156_198)(Mouse) _ 100ug
- - Source: PubMed
Publication date: 2026/04/16
Wang YanjieNusinowitz StevenYang Xian-Jie - SummaryMyogenic precursor cells within skeletal muscles are responsible for the maintenance of skeletal muscle over a lifetime. Neurotrophic and growth factors play critical roles in this maintenance and in responses of myogenic precursor cells. Both glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) play roles in the maintenance and/or development of strabismus, yet few studies have examined their roles in the control of myogenic precursor cell proliferation and differentiation. Two populations of myogenic precursor cells were isolated from extraocular and leg muscle by fluorescence-activated cell sorting: EECD34 cells, largely PITX2-positive, and PAX7-positive cells. Cultures were treated with GDNF or CNTF and processed immunohistochemically to determine proliferation and differentiation rates. Neither GDNF nor CNTF affected cell proliferation rates for either muscle. Both treatments impacted cell differentiation by increasing multinucleated cell number, with TA-derived precursor cells producing cells containing large numbers of nuclei and EOM-derived precursor cells producing shorter multinucleated fibers with fewer nuclei. These differences may explain the presence of extremely short myofibers within normal adult EOM compared with limb muscle. As GDNF and CNTF are downregulated in strabismic muscles, data suggest that myofiber length homeostasis may be disrupted in strabismic EOM and suggest possible approaches for strabismus treatment. - Source: PubMed
Publication date: 2026/04/13
Winker Austin JJohnson Laura LMcLoon Linda K - To assess the structural and functional outcomes of treatment with ciliary neurotrophic factor (CNTF) for patients with type 2 macular telangiectasia (MacTel). - Source: PubMed
Publication date: 2026/04/09
Sriranganathan AswenRajesh ZwetlanaMihalache AndrewGrad JustinPopovic Marko MKertes Peter JKohly Radha PMuni Rajeev H - The restoration of white matter damage is essential for the functional recovery observed in demyelinating diseases such as multiple sclerosis (MS). Interleukin 4 (IL-4), a type II cytokine, has been acknowledged for its protective role in modulating microglia and immune cells, thus suppressing inflammatory processes. Emerging evidence suggests that IL-4 extends beyond its immunomodulatory function, playing a part in memory, neuronal pruning, protection, and neurodegeneration. Here, our study identified the capacity of IL-4 to stimulate myelinogenesis and remyelination in the central nervous system. We observed dynamic changes in IL-4Rα expression during both developmental myelination and remyelination. Intranasal IL-4 administration during a critical postnatal period significantly enhanced myelination. Following demyelination induced by lysophosphatidylcholine, IL-4 was found to augment remyelination and restore motor function. Using genetic knockout experiments in vitro, we further showed that IL-4 binding to IL-4Rα and activating the PPARγ signaling pathway, thereby upregulating GPNMB, a downstream effector that promotes oligodendrocyte differentiation and myelination. These findings reveal a novel protective role for IL-4 in CNS repair, extending beyond its established functions in microglia, macrophages, or neurons. Intranasal IL-4 delivery may represent a promising therapeutic strategy for enhancing white matter integrity in leukodystrophies and MS. Abbreviations: MS, multiple sclerosis; IL-4, Interleukin 4; CNS, central nervous system; OPCs, oligodendrocytes precursor cells; IL-4R, IL-4 receptor; i.n., intranasal; LPC, lysophosphatidylcholine; PVL, periventricular leukomalacia; EAE, experimental autoimmune encephalomyelitis; dpi, days post immunization; dpl, days post lesion; Nkx2.2, NK2 homeobox 2; Olig2, oligodendrocyte transcription factor 2; OLs, oligodendrocytes; SOX10, SRY-Box Transcription Factor 10; PDGFRα, platelet derived growth factor receptor alpha; CNPase, 2',3'-Cyclic Nucleotide 3' Phosphodiesterase; APC, adenomatous polyposis coli; ASPA, aspartoacylase; GFAP, glial fibrillary acidic protein; Iba1, ionized calcium binding adaptor molecule 1; MBP, myelin basic protein; TEM, transmission electron microscopy; CC, corpus callosum; GCC, genu of the corpus callosum; CG, cingulum; CTX, cortex; STR, striatum; EC, external capsule; Pre-OLs, pre-myelinating oligodendrocytes; STAT6, signal transducer and activator of transcription 6; Pio, pioglitazone; T3, triiodothyronine; CNTF, ciliary neurotrophic factor; PPARγ, peroxisome proliferator-activated receptor γ. - Source: PubMed
Publication date: 2026/04/02
Yin Yu-JingLi Si-HanYu Feng-LinZhang YanDu Ruo-YanLi HuanZou Ya-RouZhang Lin-JieZhang YuanHan Bing - Researchers have postulated a link between higher levels of brain-derived neurotrophic factor (BDNF) and more favorable outcomes in patients with normal pressure hydrocephalus (NPH). However, there is no clear evidence regarding the causal association between neurotrophins and NPH. To delve deeper into this potential connection, scientists employed a rigorous method known as bidirectional Mendelian randomization (MR). This technique was utilized to explore the causal impact of various neurotrophins-such as BDNF, nerve growth factor (NGF), neurotrophin-3 (NT-3), NT-4, ciliary neurotrophic factor (CNTF), and glial cell line-derived neurotrophic factor (GDNF)-on the development or progression of NPH. - Source: PubMed
Xu TaoGan QiangWang HandongLiu HaifengHuang Xiwen