Vaspin (257_300)
- Known as:
- Vaspin (257_300)
- Catalog number:
- 002-68
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Phoenix Peptide
- Gene target:
- Vaspin (257_300)
Related genes to: Vaspin (257_300)
- Gene:
- SERPINA12 NIH gene
- Name:
- serpin family A member 12
- Previous symbol:
- -
- Synonyms:
- OL-64, Vaspin
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-21
- Date modifiied:
- 2016-04-06
Related products to: Vaspin (257_300)
'Orbit 300 Multipurpose Digital Vortexe Flat platform (30 x 30 cm) with non-slip rubber mat for use with Orbit 300 Shaker'Orbit 300 Multipurpose Digital Vortexe Microplate platform for 4 plates, for use with Orbit 300 Shaker'Orbit 300 Multipurpose Digital Vortexe Universal spring loaded clamp platform forflasks, bottles, tube racks, etc. for use with Orbit 300 Shaker(Nle253)-HSV-1 UL 26 Open Reading Frame (238-257) 98% C102H152N26O29 CAS:1 | PEB (4x) | protein extraction buffer1.5ml Screw Cap Tubes, Graduat Screw Cap Assembled, Sterile1.5ml ScrewCap Tubes,Sterile1.5ml ScrewCap Tubes,Sterile Not Self-Standing, Caps On1.5ml ScrewCap Tubes,Sterile Not Self-Standing, Caps On10% 12-well c-PAGEL 10_pk 25,000-300,000_150-2,00010% 2-D c-PAGEL 10_pk 25,000-300,000_150-2,000100bp DNA Ladder Marker (5μl T) 100,200,300,400,500,600,700,800,900,1000,1500bp100bp DNA Ladder Marker (5μl/T) 100,200,300,400,500,600,700,800,900,1000,1500bp100bp_1.5kb DNA Ladder Marker J3 100,200,300,400,500,600,700,800,900,1000,1500bp100bp_1.5kb DNA Ladder Marker J3 100,200,300,400,500,600,700,800,900,1000,1500bp Related articles to: Vaspin (257_300)
- SERPINA12 is a member of the serpin superfamily that has been extensively studied in metabolic and inflammatory disorders. In recent years, increasing evidence has highlighted its emerging role in skin physiology and dermatological diseases. SERPINA12 is expressed in multiple skin cell types, including keratinocytes and dermal fibroblasts, where it participates in the regulation of inflammation, cellular proliferation, differentiation, and tissue homeostasis. Dysregulation of SERPINA12 has been implicated in several skin disorders. In psoriasis, altered SERPINA12 expression is associated with chronic inflammation, immune dysregulation, and abnormal keratinocyte proliferation, suggesting a potential modulatory role in psoriatic pathogenesis. Furthermore, emerging studies suggest a possible involvement of SERPINA12 in palmoplantar keratoderma, where it may contribute to aberrant keratinization and epidermal barrier dysfunction. This review summarizes current knowledge on the expression patterns, biological functions, and molecular mechanisms of SERPINA12 in the skin, with a particular focus on adipocytes, psoriasis, and palmoplantar keratoderma. Understanding the role of SERPINA12 in cutaneous biology may provide new insights into disease pathogenesis and identify potential therapeutic targets for skin disorders. - Source: PubMed
Publication date: 2026/04/27
Xiao ZhenzhenWang FeiLi RuiTan Yingjian - Cardiometabolic diseases are chronic conditions arising from the common pathophysiology of metabolic and cardiovascular disorders accompanied by risk factors such as insulin resistance, obesity, type 2 diabetes, metabolic syndrome, and hypertension. In recent years, the relationship between adipokines such as PAI-1 and vaspin and these diseases has attracted increasing interest. PAI-1 increases cardiovascular risks by inhibiting fibrinolysis, and high PAI-1 levels are associated with obesity and insulin resistance. Vaspin, on the other hand, may have an inhibitory effect on the development of type 2 diabetes and metabolic syndrome by increasing insulin sensitivity. Considering the effects of dietary and lifestyle factors on these molecules, PAI-1 and vaspin are thought to have potential as early biomarkers and therapeutic targets. However, conflicting findings in the literature necessitate further research. Alongside lifestyle interventions based on healthy eating and exercise, changes in PAI-1 and vaspin levels show promise as potential biomarkers for the early diagnosis and prevention of cardiometabolic disorders and the development of personalized treatment strategies. Further research is required to better clarify the molecular mechanisms regulating PAI-1 and vaspin and to determine their potential clinical applications in the prevention and management of cardiometabolic diseases. - Source: PubMed
Publication date: 2026/03/26
Kocabas SuleSanlier Nevin - - Source: PubMed
Publication date: 2026/04/05
Pan LuluBu Zhangyu - The American Heart Association's Life's Essential 8 cardiovascular health (CVH) construct strongly predicts cardiovascular disease (CVD), yet biological processes associated with early-life CVH trajectories are unclear. We examined associations of CVH score and trajectory parameters across childhood with cardiovascular-related proteins. - Source: PubMed
Publication date: 2026/04/03
Lin ZhiRifas-Shiman Sheryl Lde Ferranti Sarah DPerng WeiHivert Marie-FranceAris Izzuddin M - Nagashima-type palmoplantar keratoderma, recently termed as SERPINB7/SERPINA12-palmoplantar epidermal differentiation disorders (pEDD) is the most prevalent palmoplantar keratoderma in East Asia, caused by variants in the SERPINB7 and SERPINA12. Sanger sequencing and next-generation sequencing (NGS) are the gold standard methods for detecting these variants, but their complexity and high cost limit clinical application. This study aimed to develop a rapid, cost-effective, and accurate detection strategy using the amplification refractory variant system-based real-time PCR (ARMS-qPCR) system. Eight key variants were selected: five in SERPINB7 (c.796C>T, c.522dupT, c.650_653delCTGT, c.455G>T, and c.745-553 T>G) and three in SERPINA12 (c.970_971del, c.635-7A>G, c.656A>G). Specific primers for wild-type and mutant sequences were designed based on the ARMS-PCR principle, and reaction conditions were optimized. The ARMS-qPCR strategy was applied to 103 blood samples from SERPINB7/SERPINA12-pEDD patients (n = 53) and healthy controls (n = 50). All samples were validated by Sanger sequencing or NGS, achieving 100% consistency in detecting key variants and an overall accuracy of 93.2% for disease prediction. In conclusion, our ARMS-qPCR strategy provides a rapid, cost-effective, and accurate method for detecting SERPINB7/SERPINA12-pEDD variants, demonstrating significant potential for clinical diagnosis and genetic counseling. - Source: PubMed
Publication date: 2026/03/27
Zhang JingyaLiu YiheLiu JuanMo RanMao XinyuYang YongChen Zhiming