LGR8 (737_754)[Cys0](Human) _ 100ug
- Known as:
- LGR8 (737_754)[Cys0](Human) _ 100ug
- Catalog number:
- 001-54
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Phoenix Peptide
- Gene target:
- LGR8 (737_754)[Cys0](Human) _ 100ug
Related genes to: LGR8 (737_754)[Cys0](Human) _ 100ug
- Gene:
- RXFP2 NIH gene
- Name:
- relaxin family peptide receptor 2
- Previous symbol:
- LGR8
- Synonyms:
- GREAT, GPR106, INSL3R, RXFPR2
- Chromosome:
- 13q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-10
- Date modifiied:
- 2018-02-23
Related products to: LGR8 (737_754)[Cys0](Human) _ 100ug
Related articles to: LGR8 (737_754)[Cys0](Human) _ 100ug
- Improving feed efficiency and reducing enteric methane emissions are key priorities for enhancing the sustainability of ruminant production systems. This study examined the genetic architecture of dry matter intake (DMI), residual feed intake (RFI), methane emissions (MEs), and BW in Merino sheep using weighted single-step genome-wide association studies. Phenotypic records were collected from 1 247 Merino sheep for DMI, 1 231 for RFI, and 1 219 for ME, all of which were genotyped using the GeneSeek® Genomic Profiler™ 50K single-nucleotide polymorphism (SNP) array, as well as BW records from 78 466 animals, of which 1 626 were genotyped. Genomic regions explaining at least 0.5% of the additive genetic variance were identified for all traits, with several regions shared by at least two traits. Shared regions on chromosomes 5, 6, 10, 19, and 21 were further evaluated using the Close Linkage versus Pleiotropism (CLIP) test to distinguish pleiotropy from close linkage, revealing pleiotropic loci (chromosome 10 shared between DMI and RFI; chromosome 19 shared between DMI and ME) and closely linked loci influencing multiple traits. Candidate genes located within these regions include RXFP2, members of the ITIH gene family, and FADS1-2, which have been previously associated with growth, metabolism, and tissue development, reflecting potential biological mechanisms underlying feed intake, growth, and methane production. No single genomic window exceeded 6.73% of the additive genetic variance, and even within regions showing the strongest window-based signals, the combined effect of the five most informative SNPs accounted for less than 0.23% of the genetic variance, supporting a highly polygenic architecture across all traits, with ME exhibiting the most pronounced polygenic pattern. Several of the candidate genes identified here have also been reported in other ruminant and non-ruminant species, suggesting partially conserved biological mechanisms of potential relevance beyond Merino sheep. These findings provide a foundation for future studies aimed at refining genomic prediction models and support the use of multitrait evaluations and Bayesian approaches incorporating GWAS-derived priors for traits that are difficult and expensive to measure, such as feed efficiency and methane emissions. - Source: PubMed
Publication date: 2026/06/10
Carracelas BVera BNavajas E AAguilar IDe Barbieri ICiappesoni G - The RXFP2 gene is a key regulator of horn morphology in sheep (Ovis aries Linnaeus), with a 1.78-kb insertion in its 3'-untranslated region (UTR) previously linked to the polled phenotype. However, horned individuals homozygous for this insertion (1.78 kb/) have been observed in typically polled breeds such as Hu sheep, suggesting additional regulatory mechanisms. In this study, a significant horn-associated quantitative trait locus (QTL) on chromosome 10 was identified through genome-wide association analysis which was consistent with a previous study. We found that the 1.78-kb insertion in the 3'-UTR of RXFP2 is associated with horn status across sheep breeds, and that elevated RXFP2 expression correlates with horn development even in 1.78 kb/ individuals, as revealed by expression analyses in multiple breeds. RNA-seq and hormonal profiling further demonstrated that the INSL3/RXFP2 signaling axis, particularly its interactions with hormones such as testosterone, plays a central role in horn morphogenesis. These results indicate that horn development is modulated not only by structural variations in RXFP2, but also through its transcriptional and hormonal regulation, providing new insights into the polygenic basis of horn formation and informing breeding strategies for polled sheep. - Source: PubMed
Wang HaitaoLi TingtingChen JieranWang LiminLi XiaZhang YutingZhang NaZhang ZhichaoMa RunlinWang DaxiangHuang XunLiu Qiuyue - This study performed deep sequencing of the RXFP2 gene in three sheep breeds: PT, QHS, and HS. Association analysis identified four significant variant loci: SNP25, SNP57, SNP70, and SNP28. GMDR and LASSO analyses confirmed the crucial role of SNP28 in horn trait regulation. Loci interaction analysis revealed an epistatic effect between SNP25 and SNP57, moreover further supporting that SNP25 may be a locus contributing to breed-specific differentiation. Linkage disequilibrium analysis indicated that SNP70 exhibits stable heritability, while the genetic effect of SNP57 is influenced by its haplotype background. Population genetics validation demonstrated that SNP28 and SNP57 contribute to larger horn size in sheep, with SNP57 exhibiting a sex-specific effect. SNP70 showed strong explanatory power for the polled trait in Plateau-type Tibetan sheep but may be associated with the pathogenicity of cryptorchidism, while SNP25 was confirmed to be unrelated to horn traits. Furthermore, preliminary genetic studies on the scurs trait revealed its underlying genetic complexity. These findings provide promising genetic tools for sheep breeding. - Source: PubMed
Publication date: 2026/04/08
Hu XiliuHan BuyingLiu DehuiLi XueChen CunxiaXu TengBao GuoxiangSu WanyingLi GuoxingLi RongXiang XueMa WulongZhao KaiTian Dehong - In briefCurrent understanding of testicular descent mechanisms, mainly based on rodent models, attributes a central role to testicular hormones. This study examines the hormonal receptivity and potential sex differences of human caudal genital ligaments (also named gubernaculum in males) during organogenesis. Abstract In both sexes, fetal gonads are connected to the abdominal wall by caudal genital ligaments (CGLs). The male CGL (gubernaculum testis) drives testis descent under the influence of testicular hormones, whereas the fate of the female CGL is thought to result from the absence of these hormones. However, the process in humans has not been clearly demonstrated. We here examined the expression patterns of receptors and metabolizing enzymes of gonadal hormones in CGLs collected from male and female human first trimester fetuses and from boys with uni- or bi-lateral cryptorchidism by using real-time quantitative PCR, in situ hybridisation, and when possible, immunostaining. We show that the CGLs of both sexes express receptors for insulin-like factor 3 (RXFP2), androgens, estrogens, and for members of the transforming growth factor beta family during the first trimester of pregnancy. The expression of RXFP2 increased with fetal age in both sexes, was heterogeneous, and was unrelated to proliferation. Androgen receptor expression also tended to increase with age, particularly in males. Notably, five alpha reductase type 2 (SRD5A2) and estrogen receptor (ESR1) mRNA levels increased significantly with age in both sexes, but showed clear sexual dimorphism. In contrast, ACVR2B and BMPR1B mRNA decreased with age in both sexes, unlike stable levels of AMHR2 mRNA. In boys with cryptorchidism, gene expression remained consistent regardless of age, ligament position, or appearance. The expression of male hormone receptors and the increased expression of ESR1 in female CGLs raises questions about their physiological significance and susceptibility to xenoestrogens during early development. - Source: PubMed
Desdoits-Lethimonier ChristèleCoiffec-Dorval IsabelleToupin MaryneBey MarieGuinot AudreyLavoué VincentFrémond BenjaminMazaud-Guittot SéverineJégou Bernard - Goat reproductive performance is a key determinant of the productivity and economic value of goat farming, especially in meat and milk production. In a previous study, to investigate the genetic basis of prolificacy, we divided goats into groups according to their consistent reproductive performance (producing either single kids or twins) over five consecutive kidding cycles, and performed whole-genome resequencing and RNA-seq analysis on their ovarian tissues. Through integrated analysis, we identified three candidate genes- (insulin-like growth factor 2 mRNA-binding protein 1), (cell division cycle 25A), and (relaxin family peptide receptor 2)-as potential key regulators of reproductive capacity. Using goat ovarian granulosa cells, we systematically assessed the impact of each gene through gain- and loss-of-function experiments. Overexpression of promoted cell proliferation and suppressed apoptosis, underscoring its role in maintaining cellular viability. Conversely, its knockdown significantly impeded growth and induced cell death. Similarly, enhanced granulosa cell proliferation, whereas its knockdown led to marked growth impairment and increased apoptosis. Proliferation was also enhanced by overexpression but impaired upon its knockdown, suggesting that is functionally important for follicular development. Collectively, these findings establish , , and as fundamental regulators of granulosa cell dynamics and ovarian follicular development, providing crucial functional insights and promising targets for genetic selection to enhance reproductive efficiency in goats. - Source: PubMed
Publication date: 2026/03/07
Yang HaiyanMa QianchengWang ZhiyingZhang ShanWang LuqiZhu HaijingLan XianyongWang KePan Chuanying