SARS Spike
- Known as:
- SARS Spike
- Catalog number:
- ANT-179
- Product Quantity:
- 100µg
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- SARS Spike
Related genes to: SARS Spike
- Gene:
- SARS NIH gene
- Name:
- seryl-tRNA synthetase
- Previous symbol:
- -
- Synonyms:
- SERS
- Chromosome:
- 1p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-06-09
- Date modifiied:
- 2014-11-18
- Gene:
- SARS2 NIH gene
- Name:
- seryl-tRNA synthetase 2, mitochondrial
- Previous symbol:
- SARSM
- Synonyms:
- FLJ20450, mtSerRS, SerRSmt, SARS, SERS, SYS
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-10-09
- Date modifiied:
- 2016-11-09
Related products to: SARS Spike
62 kDa RNA-binding protein,Oryctolagus cuniculus,Rabbit,SARS,Serine--tRNA ligase,SerRS,SERS,Seryl-tRNA synthetase, cytoplasmic,Seryl-tRNA(Ser_Sec) synthetaseSARS coronavirus N Protein monoclonal antibody, clone 38j4SARS coronavirus N Protein monoclonal antibody, clone 8k5hA' SARS-CoV, Spike Antibody (OAMA02852)A' SARS-CoV, Spike Antibody (OAMA02863)A'SARS-CoV, M protein (NT) antibodyA'SARS-CoV, M protein (NT) antibody Polyclonal Antibodies Primary antibodiesA'SARS-CoV, M protein (NT) antibody Polyclonal Antibody Host: RabbitACE2 (SARS Receptor) Antibody (C-term)ACE2 (SARS Receptor) Antibody (C-term)ACE2 (SARS Receptor) Antibody (C-term) Blocking PeptideACE2 (SARS Receptor) Antibody (C-term) Blocking PeptideACE2 (SARS Receptor) Antibody (C-term) Purified Rabbit Polyclonal Antibody (Pab) Applications WB, IHC, EACE2 (SARS Receptor) Antibody (C-term) Purified Rabbit Polyclonal Antibody (Pab) Applications WB, IHC, EACE2 (SARS Receptor) Antibody (Center) Related articles to: SARS Spike
- The COVID-19 pandemic has revealed the importance of wastewater-based epidemiology (WBE) due to its advantages over traditional surveillance systems. However, low viral prevalence poses a significant challenge for reliable detection of SARS-CoV-2 in endemic wastewater settings. This study aimed to improve detection sensitivity of SARS-CoV-2 by applying the chip-based digital PCR (dPCR) approach targeting the CDC N1 and N2 genes to wastewater samples processed with a combined magnetic bead concentration method during a low-prevalence period in South Korea. Here, the evaluation results using dPCR combined with magnetic bead concentration showed higher viral loads and lower variability compared to the commonly used electronegative filtration method. Comparative analysis of the dual-target N1 + N2 and E-Sarbeco assays revealed that the N1 + N2 assay yielded significantly higher concentrations (4.73 ± 0.19 log GC/L) than the E gene assay (4.27 ± 0.25 log GC/L) in dPCR analysis (p < 0.01). PMMoV normalization increased the Pearson correlation coefficient between SARS-CoV-2 concentrations and clinical case data from R = 0.1 to R = 0.31; however, this was not statistically significant. These findings contribute to enhancing detection sensitivity for SARS-CoV-2 wastewater surveillance in endemic settings. - Source: PubMed
Jo YoungraeChoi SeoyoonLee Do Gyun - Long-term cardiovascular consequences of COVID-19 remain unclear, particularly in non-hospitalized individuals. We investigated longitudinal changes (~3 years) in cardiovascular risk factors, cardiac biomarkers, physical functioning, and activity in non-hospitalized COVID-19 individuals versus age- and sex-matched controls. Assessments were performed in 2021 (~6 months post-infection) and repeated 3 years after initial SARS-CoV-2 infection among 101 non-hospitalized COVID-19 participants and 101 healthy age- and sex-matched controls. Multiple imputation was adopted to adjust for missing data due to drop-out. Based on the absence (-) or presence (+) of infections during follow-up, four groups were created: COVID-19/- (n = 45), COVID-19/+ (n = 56), Control/- (n = 29), and Control/+ (n = 72). Additionally, sex-stratified analyses were performed. No changes were found in parameters related to cardiovascular risk factors, cardiac biomarkers, physical functioning and physical activity across the 3-year follow-up, showing no time × group effects for any of the outcomes (all p-values >0.05). Sex-stratified analyses and complete-case sensitivity analysis reinforced our results. Overall, we found no changes in cardiovascular risk factors, cardiac biomarkers, physical functioning and activity across a 3-year follow-up in non-hospitalized COVID-19 individuals compared to healthy controls, independent of infections during follow-up. This suggests that non-hospitalized COVID-19 did not induce long-term deleterious changes in cardiovascular health or physical characteristics. - Source: PubMed
Vloet Janneke I ABakker Esmée Avan der Sluijs Koen MSperetta Guilherme Fvan der Horst ArmandoEijsvogels Thijs M HThijssen Dick H J - Surveillance of severe acute respiratory illness (SARI) in Brazil provides an early warning system for respiratory outbreaks, including COVID-19, and statistical nowcasting methods are vital for correcting long and variable reporting delays that would otherwise hinder timely decision-making. Coherent joint prediction of SARI and COVID-positive SARI in Brazil could improve outbreak response planning and hospital resource management, but most existing nowcasting methods only target one outcome at a time. Furthermore, existing approaches usually focus solely on reconstructing recent incidence rather than forecasting future trends, which could support more proactive risk mitigation. Here, we propose a Bayesian hierarchical framework for joint nowcasting and short-term forecasting of two outcomes, where one is a strict subset of the other. Building on the generalized-Dirichlet-multinomial (GDM) method for correcting delayed reporting, a new beta-binomial component links SARI and COVID-positive counts, while separate conditional GDM components capture their distinct delay patterns. To allow for changes over time in the level of disease and delay distributions, flexible latent effects are included in all model components. Using national surveillance data from 2021 to 2024, we conduct a 20-date rolling prediction experiment across Brazil's 27 federative units. Compared to a well-established Bayesian nowcasting approach, our joint model achieves about one-third lower mean absolute error and continuous ranked probability score for contemporaneous nowcasts, with the largest gains in high-incidence regions. Meanwhile, energy scores indicate improved calibration for joint forecasts of total and COVID-positive SARI relative to comparable independent models. - Source: PubMed
Halliday AlbaStoner OliverEconomou TheoBastos Leonardo Soares - Current mRNA-LNP systems face challenges in efficient co-delivery of nucleic acid adjuvants, limiting their capacity to elicit robust cellular immunity. To overcome the dissociation limitations of physically admixed CpG in conventional lipid nanoparticles, we developed a covalent conjugation platform that integrates TLR9 agonists with phospholipids via amide bonding. We synthesized a DSPE-CpG conjugate, which exhibited high loading efficiency (97.1%) onto mRNA-LNPs. The immune activation efficacy was evaluated in models encoding SARS-CoV-2 spike protein and HBV antigens. The DSPE-CpG-mRNA LNP system demonstrated enhanced cellular uptake via clathrin-mediated endocytosis, superior lymph node targeting of the adjuvant, and improved antigen expression in vivo. In the SARS-CoV-2 model, it induced high levels of IFN-γ⁺CD8⁺ T cells and elicited higher titers of specific IgG and neutralizing antibodies. In the HBV model, it significantly enhanced antigen-specific CD107a and FasL CTLs. Acute toxicity tests revealed no significant adverse effects. This covalent conjugation strategy, by ensuring co-localized delivery of antigen and adjuvant, provides an innovative and translatable platform for enhancing mRNA vaccine efficacy. - Source: PubMed
Publication date: 2026/04/17
Ji WantingZhu KeerZhou YanyanYan HaominWei JianiZhu YingLi ShengHong YuqiDai JinyaoDong ShaohuaHu HaoyangYou JianQiu YunqingLou Yan - - Source: PubMed
Publication date: 2026/04/18
Aqillouch SafaaLaazaazia OumaimaOuladlahsen AhdNoureddine RachidBaba HanâAkarid KhadijaBenjelloun SoumayaPineau PascalEzzikouri Sayeh