CD44 FITC
- Known as:
- CD44 fluorecein
- Catalog number:
- ANT-295
- Product Quantity:
- 500µg
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- CD44 FITC
Related genes to: CD44 FITC
- Gene:
- CD44 NIH gene
- Name:
- CD44 molecule (Indian blood group)
- Previous symbol:
- MIC4, MDU2, MDU3
- Synonyms:
- IN, MC56, Pgp1, CD44R, HCELL, CSPG8
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD44 FITC
Related articles to: CD44 FITC
- The aim of present work was to develop and optimise hyaluronic acid-functionalised, chloroquine-loaded solid lipid nanoparticles (HA-CQL-SLNs) for CD44 receptor-mediated therapy of rheumatoid arthritis. The Chloroquine base was precipitated and characterised using UV spectroscopy, FTIR, and DSC. Solid lipid nanoparticles were prepared by melt emulsification followed by probe sonication and optimised using a Box-Behnken design. Particle size, polydispersity index, zeta potential, and entrapment efficiency were evaluated. Ex vivo intestinal uptake was assessed using endocytosis inhibitors, while in vivo pharmacokinetic studies with cycloheximide pretreatment evaluated lymphatic transport. Therapeutic efficacy was studied in arthritic rats. The optimised HA-CQL-SLNs showed a particle size of 412.8 ± 0.71 nm, zeta potential of -9.6 ± 2.3 mV, and entrapment efficiency of 94.6 ± 0.49% (w/w). The lymphatic uptake involved clathrin- and caveolae-mediated endocytosis which was established by reduced systemic drug exposure in animals receiving Cycloheximide pre-treatment. HA-CQL-SLNs significantly reduced paw oedema and joint damage. Thus it can be concluded that HA-CQL-SLNs enhanced bioavailability and therapeutic efficacy, demonstrating potential as a targeted oral delivery system for rheumatoid arthritis. - Source: PubMed
Publication date: 2026/05/19
Bhalekar Mangesh RMadgulkar Ashwini RRewachandani Yogesh RDagade Vidhi Anil - While secreted phosphoprotein 1 (SPP1) drives macrophage M2 polarization and cancer progression in multiple malignancies, its role in thyroid cancer remains poorly understand. This study investigated the roles and mechanisms of thyroid cancer-derived exosomal SPP1 in regulating macrophage M2 polarization and malignant progression in thyroid cancer. - Source: PubMed
Publication date: 2026/05/19
Yang JiwenYin WeiliGe JunliangGao GuangjianYao XinmingHuang Yayin - Y-box binding protein 1 (YB-1) is a multifunctional RNA- and DNA-binding protein with broad regulatory functions in gene expression, particularly at the posttranscriptional level. Here, we demonstrate that conditional deletion of YB-1 at the double-positive (DP) thymocyte stage causes an ∼80% reduction of invariant natural killer T (iNKT) cells in thymus, spleen, and liver, evident already in day-14 neonates and persisting into adulthood. Our data reveal CD44NK1.1 stage 1 accumulation and a selective loss of CD44NK1.1 stage 3 iNKT cells, indicating a postselection maturation defect. All iNKT cell subsets (iNKT1, iNKT2, iNKT17) were reduced, with thymic iNKT1 and splenic iNKT17 cells most severely affected. PMA/ionomycin-stimulated YB-1-deficient iNKT cells showed preserved IFN-γ/IL-4 frequencies but reduced per-cell cytokine production and a loss of IL-17 production. Interestingly, YB-1 DP thymocytes showed increased CD1d levels, suggesting increased TCR signal strength in the thymus of YB-1-deficient mice. Whereas CD5 levels were elevated, basal Nur77, ICOS, and CD122 (IL-15Rβ) expression were reduced in iNKT cells. Furthermore, apoptosis was increased, particularly at iNKT stages 2-3. Together, these findings identify YB-1 as a central regulator of iNKT cell development that integrates TCR, co-stimulatory, and IL-15 signaling to ensure postselection iNKT cell maturation, effector subset specification, and survival. - Source: PubMed
Schulze SilviaKnop LauraJantz-Naeem NouriaDovhan VladyslavaFricke StephanKahlfuß SaschaSchüler ThomasBommhardt Ursula - Alpha-Lipoic Acid (ALA) is known for its antioxidant and antiinflammatory properties; however, its direct role in neurogenesis remains undefined. This study evaluated the neurogenic potential of the R-enantiomer (R-ALA) using transcriptomic profiling and in vitro validation. - Source: PubMed
Publication date: 2026/05/11
Gupta SamriddhiKaushal ShrutiBhargava PriyanshuIshida YoshiyukiTerao KeijiKaul Sunil CDhanjal Jaspreet KaurWadhwa Renu - Circulating tumour cells (CTCs) are mediators of cancer dissemination and the formation of metastasis, which is the leading cause of cancer-related deaths. Experimental models derived from CTCs contribute to understanding the biology of CTCs, their role in dissemination, and the discovery of potential drugs targeting CTCs. - Source: PubMed
Publication date: 2026/05/18
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