CD44
- Known as:
- CD44
- Catalog number:
- ANT-242
- Product Quantity:
- 500µg
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- CD44
Related genes to: CD44
- Gene:
- CD44 NIH gene
- Name:
- CD44 molecule (Indian blood group)
- Previous symbol:
- MIC4, MDU2, MDU3
- Synonyms:
- IN, MC56, Pgp1, CD44R, HCELL, CSPG8
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD44
Related articles to: CD44
- Allergic contact dermatitis, or contact hypersensitivity (CHS), is a pathological adaptive immune response that paradoxically induces hair regeneration, yet its underlying mechanisms remain unclear. We integrated high-resolution spatial transcriptomics and single-cell RNA sequencing to map the intricate interactions between immune cells, stroma, and hair follicles during CHS-induced hair growth in mice. Among all immunocytes, macrophages underwent the most prominent compositional and functional remodeling. We resolved five transcriptionally distinct macrophage subsets, with contact hypersensitivity driving a shift from homeostatic antigen-presenting cells toward a pro-inflammatory CD14SPP1 population. Trajectory analysis revealed divergent differentiation paths under homeostatic versus allergic conditions, highlighting the plasticity of skin macrophages. Mechanistically, CD14SPP1 macrophages secreted SPP1 (osteopontin), which engaged CD44 on hair follicle stem cells to activate PI3K-AKT signaling and trigger their proliferation. Notably, canonical pro-inflammatory cytokine signaling through TNF-α and IL-1 was dispensable for this process, underscoring the specificity of the SPP1-CD44 axis in immune-mediated hair regeneration. These findings reveal a macrophage-dependent mechanism of immune-mediated hair regeneration, offering therapeutic insights into immune-stem cell crosstalk. - Source: PubMed
Publication date: 2026/09/11
Huang Kai-RongChang Nai-WenTai Kang-YuLin Jian-DaChang Che-FengYang Kai-ChienMai-Yi Fan SabrinaLin Sung-Jan - Specific binding of the hepatitis B virus (HBV) pre-S1 protein to Na/taurocholate Cotransporting Polypeptide (NTCP) on the surface of hepatocytes mediates viral entry into host cells. Exosomes, which serve as natural delivery vehicles, can protect their cargo from degradation in the extracellular environment. - Source: PubMed
Publication date: 2026/09/11
Yin Yan-FengYan Chun-TaoGuan ZhengYu LuLei Chun-MeiWang DongdongYang Jiayin - Endothelial cells were among the first cells identified to have a surface glycocalyx, but its functions are still elusive. Within the glycocalyx are many glycoproteins whose O-glycosylation is partly regulated by Cosmc, an essential chaperone for functional activity of T-synthase that adds galactose to O-glycans initiating their elongation. Using mice with inducible deletion of either Cosmc (C1Galt1C1) or the sialyltransferase St3Gal-1 in lymphatic endothelial cells (LEC), we discovered that loss of elongated O-glycans is accompanied by major changes in glycoprotein composition, including podoplanin, CD44, Lyve-1, and ICAM-1. These changes in the endothelial glycocalyx are sensed by adhesion molecules, such as Siglec-1, and lead to major changes in the size and phenotype of lymph node macrophage populations. Our findings demonstrate the crucial roles of O-glycosylation in regulating LEC functions and lymph node macrophage differentiation. - Source: PubMed
Frey JasminRatter AnnkathrinBrigger FinnCielen LouieKunz PascalTulin EaMikos KingaDieterich LotharD'Addio MarcoHalin CorneliaCummings Richard DOtto Vivianne I - Clonal hematopoiesis of indeterminate potential (CHIP) is a precursor to myeloid malignancies, yet the functional proteomic landscape that governs clonal fitness and microenvironmental remodeling remains poorly understood. This systematic review consolidates high-resolution proteomic evidence to map the transition from stable CHIP to overt malignancy. - Source: PubMed
Publication date: 2026/08/27
Husein Jana HKhayata Rasha MJahangir AishaMansour Ghaith KHajjar Ahmed WSajid Muhammad Raihan - Cancer is a leading cause of death. Melanoma, a highly metastatic and aggressive skin cancer, has seen rising mortality rates despite advancements in chemotherapy. Recently, immunotherapy has emerged as a promising approach to address the limitations of conventional treatments. This study developed a tumor microenvironment-sensitive nanoparticle (HA-NPs) for a nanovaccine. The nanoparticle is composed of CD44-targeting hyaluronic acid, pH-responsive ammonium bicarbonate, resiquimod (a TLR-7/8 agonist), Poly I:C (a TLR-3 agonist), and the tumor-specific antigen ovalbumin (OVA), ensuring a targeted and effective approach to treatment. The combination of dual adjuvants (R848 and Poly I:C) enhances the immune response, while ammonium bicarbonate ensures pH sensitivity, improving targeted delivery and effectiveness in the tumor microenvironment. The antitumor efficacy of the nanovaccine was evaluated in a highly immunogenic, OVA-expressing B16F10 murine tumor model. The intratumoral administration of HA-NPs harnessed the adjuvant potency of R848 and Poly IC, thus enhancing antitumor immunity. Additionally, immune cell profiling revealed elevated levels of mature dendritic cells , as well as CD8 T cells, and reduced levels of tumor-associated immunosuppressive cells (TAICs), such as regulatory T (Treg) cells, within the tumors. Overall, this study demonstrated the potential of HA-NPs to elicit antitumor solid immunity through the targeted immunomodulation of antigen-presenting cells and the reduction of tumor-associated immune cells (TAICs), offering a promising avenue for melanoma treatment. - Source: PubMed
Publication date: 2026/09/11
Pillarisetti ShameerSathiyamoorthy PadmanabanJung Tae-YoungUthaman SajiPark In-Kyu