CD44
- Known as:
- CD44
- Catalog number:
- ANT-242
- Product Quantity:
- 500µg
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- CD44
Related genes to: CD44
- Gene:
- CD44 NIH gene
- Name:
- CD44 molecule (Indian blood group)
- Previous symbol:
- MIC4, MDU2, MDU3
- Synonyms:
- IN, MC56, Pgp1, CD44R, HCELL, CSPG8
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD44
Related articles to: CD44
- Hepatocyte ballooning is a defining histological marker of progressive steatohepatitis, but its molecular basis remains poorly defined. - Source: PubMed
Publication date: 2026/09/12
Ganguly DebopriyoMondal BandanaDas SubhasDey IndrashishMandal AyanGhosh TrinathDeo MonalishaAhmed MisbaBanerjee SomaChatterjee AnkitaBasu Priyadarshi - Dry eye disease is a chronic inflammatory disorder of the ocular surface in which tear film instability and hyperosmolarity perpetuate a self-sustaining cycle of epithelial damage and inflammation; however, the therapeutic efficacy of topical cyclosporine A (CsA), a mainstay of treatment, is severely limited by rapid tear clearance and poor ocular bioavailability. Here, we developed a CsA-modified hyaluronic acid conjugate (HA-CsA) that spontaneously self-assembled into nanoparticles for topical DED therapy. HA-CsA nanomicelles (HCN) were synthesized through thiol-maleimide coupling and exhibited good dispersibility and stability in physiological media, with tear-compatible pH and osmolality. Under hyperosmotic stress, CD44 expression was upregulated in human corneal epithelial cells, and R6G-labeled HCN showed markedly enhanced cellular uptake compared with free R6G, indicating improved epithelial delivery. Functionally, HCN demonstrated greater cytocompatibility than free CsA and more effectively suppressed hyperosmotic stress-induced expression of IL-1β, IL-6, IL-8, TNF-α, and MMP-9. In a desiccating-stress mouse model of DED, topically administered HCN significantly improved corneal epithelial integrity, tear secretion and goblet cell survival while broadly attenuating inflammatory gene expression, macrophage activation and epithelial apoptosis, outperforming free cyclosporine A across all parameters. This conjugation-driven nanoplatform integrates tear film stabilization, targeted epithelial delivery and sustained local immunomodulation into a single, well-defined formulation, providing a promising translational strategy for interrupting the vicious inflammatory cycle that drives dry eye disease. - Source: PubMed
Publication date: 2026/09/21
Lin ZhenyiCheng MingruiCui HaonanChen YanminJiang KaiZhu LijuanXu ChanghuaHong JiaxuZhang Chuan - Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, and virtually all patients relapse on standard temozolomide (TMZ) plus radiotherapy. The molecular mechanisms that allow residual tumor cells to survive treatment, reshape the microenvironment, and seed a drug-resistant recurrence remain incompletely understood. We analyzed paired bulk RNA-seq from 13 primary-recurrent patient pairs (GSE139533), used two published primary GBM single-cell/single-nucleus samples (GSE138794/GSM4119534 and GSE174554/GSM5319503; 5244 quality-controlled cells/nuclei) solely for cellular-context mapping, and evaluated an exploratory bulk-derived gene set in TCGA-GBM. Paired testing of 18,445 genes identified one significant gene at FDR 〈 0.05 and |log2FC| 〉 0.3: IL4I1 (log2FC = 1.49, FDR = 0.023). A 40-gene exploratory set was defined as the 40 positive paired-effect genes with the strongest paired-test evidence in the same 13 pairs and used descriptively; its mean paired score difference was 1.02 z-score units, but no independent significance test was assigned to this within-cohort score. In the primary single-cell references, the set scored highest in Myeloid-like cells, providing cellular context without constituting a primary-recurrent single-cell comparison. TCGA-GBM showed a weak, non-significant baseline survival association (Cox HR 1.30, 95% CI 0.91-1.87, P = 0.15). A TMZ-resistant U251 derivative had a higher TMZ IC50 than parental cells (612 vs 89 µM), and Western blotting showed increased MGMT, CD44, Vimentin, HIF-1α, OPN and PD-L1 across three biological experiments. Together, these data provide a paired bulk description of recurrence-associated expression and use primary single-cell references only to localize the exploratory signal. - Source: PubMed
Publication date: 2026/09/19
Kong XuandongZhao MingJin QichaoPan Bolin - As a critical component of E3 ubiquitin ligase complexes, FBXO17 exhibits either tumor-promoting or tumor-suppressing in a variety of tumors, but its biological function and molecular mechanism in prostate cancer (PCa) are still unclear. FBXO17 expression in PCa cell lines and normal prostate epithelial cells (RWPE-1) was assessed using Western blot. The malignant biological behavior of the cells was evaluated using EdU staining, Transwell assay, and flow cytometry. The proportion of CD44CD133 stem cell subsets was determined via flow cytometry, and the stemness of PCa cells was evaluated using the sphere formation assay. FerroOrange staining, transmission electron microscopy, and the C11 BODIPY kit were used to detect ferroptosis-related indicators. The subcutaneous tumor model of nude mice was constructed to monitor tumor growth, and pathological staining was applied to evaluate tumor cell proliferation and apoptosis. Epithelial-mesenchymal transition (EMT) markers, ferroptosis-related proteins, stem cell markers, and Wnt/β-catenin axis-related proteins were determined through Western blot. FBXO17 expression was markedly decreased in PCa cell lines. FBXO17 overexpression suppressed malignant behaviors and the EMT process, promoted cell apoptosis, down-regulated stem cell marker expression, reduced CD44CD133 cell subsets, and inhibited tumor sphere formation in DU-145 and PC3 cells. Overexpression of FBXO17 also significantly increased the levels of Fe and lipid peroxides and led to abnormal mitochondrial morphology. Combined with the ferroptosis inducer Erastin, further enhanced the tumor suppressor effect of FBXO17 overexpression. Moreover, FBXO17 overexpression hindered the Wnt/β-catenin axis; the pathway activator LiCl reversed the ferroptosis and tumor suppressor effects mediated by FBXO17 overexpression, and combined with Erastin could restore the above effects. In vivo, FBXO17 overexpression effectively suppressed tumor growth, while inhibiting stem cell-like properties and promoting ferroptosis; LiCl weakened the anti-tumor effect of FBXO17, and combined with Erastin reversed this effect. In conclusion, by hindering the Wnt/β-catenin pathway, overexpression of FBXO17 promotes ferroptosis and subsequently inhibits the malignant phenotype and stemness properties of PCa cells. - Source: PubMed
Publication date: 2026/09/19
Lu TianzeXu XinyuJiang ZhaoshengYu QiuXue Boxin - The optimal choice of chemotherapy regimen for resectable colorectal liver metastases (CRLM) is still undetermined. The study aimed to estimate the impact of perioperative or adjuvant chemotherapy on disease-free survival (DFS), and explore the underlying mechanisms which influence chemotherapy efficacy. - Source: PubMed
Publication date: 2026/09/04
Cheng Chun-LiangTong Shan-YouMo Shao-BoCai San-JunPeng Jun-JieHu Xiang