PON1
- Known as:
- PON1
- Catalog number:
- ENZ-299
- Product Quantity:
- 2µg
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- PON1
Related genes to: PON1
- Gene:
- PON1 NIH gene
- Name:
- paraoxonase 1
- Previous symbol:
- PON
- Synonyms:
- ESA
- Chromosome:
- 7q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2014-11-19
Related products to: PON1
Related articles to: PON1
- Clopidogrel resistance (CR) may diminish its antiplatelet effect, thereby increasing the risk of cardiovascular and cerebrovascular events. The cause of CR remains unclear, and it may be related to pharmacogenomics and coagulation markers. Machine learning is a novel approach to investigate the correlations among various factors. This study aimed to investigate the factors influencing CR in Chinese patients with ischemic stroke and to develop a precise and reliable predictive model for CR using machine learning. - Source: PubMed
Publication date: 2026/04/23
Xu BeimingGu LantingLin GuanwenNi HongyangShi HaoqiangChen Bing - - Source: PubMed
Publication date: 2026/04/29
Onay YasinÇelik Gül GülşahKurtuluş FigenKerimak-Öner Mine NazanDemirci TunaKaya Mustafa Oğuzhan - Seasonal heat stress pre- and postnatally is associated with altered health and growth in dairy calves. This study investigated the potential associations between birth season and the inflammatory response and oxidative stress status in Holstein calves during the first 90 days of life. Calves born in summer (n = 20) and winter (n = 21) were monitored longitudinally. Blood samples were collected from the calves immediately after birth (before colostrum intake; hour 0), at 12 and 24 h, and subsequently on days 4, 6, 8, 15, 21, 30, 60, and 90. Total protein (TP), Brix percentage, inflammatory parameters (IL-17A, IL-10, IL-6, IL-1β, TNF-α, IFN-γ, haptoglobin, LPS), and oxidative stress markers (NO, PON1, TAS, TOS, OSI) were measured in serum samples. Data was evaluated using Linear Mixed Models. TNF-α, NO, and OSI levels were significantly higher in the summer group, while haptoglobin, IL-6, IL-10, IL-17A, and IFN-γ levels were higher in the winter group. PON1 levels increased after day 15 in both groups but remained lower in the summer group, potentially reflecting a depletion of antioxidant capacity. LPS and IFN-γ levels showed a decreasing trend from day 30, and IL-1β and IL-10 levels from day 60 until day 90. Serum TP and Brix values were higher in the winter group. In conclusion, the elevated acute-phase and cytokine responses coupled with more severe clinical findings in winter calves reflect a dysregulated inflammatory process due to higher infection pressures in winter conditions. The gradual decline in LPS and inflammatory mediators over time may associated with the maturation of the intestinal epithelial barrier and the achievement of immune homeostasis. - Source: PubMed
Publication date: 2026/04/21
Akköse MehmetEr CenkYazlık Murat OnurKaya UfukPekcan MertKanca HalitVural Mehmet Rıfat - - Source: PubMed
Publication date: 2026/04/25
Wei XiQin RongYin LiangIqbal Muhammad AsadShaibu ZakariLi GuoruiWu Ting - Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors offer a novel approach for reducing low-density lipoprotein cholesterol (LDL-C) levels in patients with familial hypercholesterolemia (FH). In our study, we aimed to compare the plasma proteome profiles of heterozygous FH (HeFH) patients and non-FH patients treated with PCSK9 inhibitors (PCSK9i). - Source: PubMed
Dlouha DanaPompach PetrHorackova JanaHubacek Jaroslav AloisBlaha Vladimir