ZNF213 Antibody
- Known as:
- ZNF213 Antibody
- Catalog number:
- ENZ-007760-M01
- Product Quantity:
- 0.1mg
- Category:
- Antibodies
- Supplier:
- Zyagen
- Gene target:
- ZNF213 Antibody
Related genes to: ZNF213 Antibody
- Gene:
- ZNF213 NIH gene
- Name:
- zinc finger protein 213
- Previous symbol:
- -
- Synonyms:
- CR53, ZKSCAN21, ZSCAN53
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-23
- Date modifiied:
- 2014-11-19
Related products to: ZNF213 Antibody
Related articles to: ZNF213 Antibody
- Breast cancer is one of the most commonly diagnosed malignancies worldwide, while the triple negative breast cancer (TNBC) is the most aggressive and virulent subtype in breast cancers. Compared with luminal type breast cancers, which could be well controlled by endocrine treatment, TNBC is worse in prognosis and lack of effective targeted therapy. Thus, it would be interesting and meaningful to identify novel therapeutic targets for TNBC treatments. Recent genomic data showed the activation of Hippo/YAP signaling in TNBC, indicating its critical roles in TNBC carcinogenesis and cancer progression. Hippo/YAP signaling could subject to several kinds of protein modifications, including ubiquitination and phosphorylation. Quite a few studies have demonstrated these modifications, which controlled YAP protein stability and turnover, played critical role in Hippo signaling activation In our current study, we identified ZNF213 as a negative modifier for Hippo/YAP axis. ZNF213 depletion promoted TNBC cell migration and invasion, which could be rescued by further YAP silencing. ZNF213 knocking down facilitated YAP protein stability and Hippo target gene expression, including CTGF and CYR61. Further mechanism studies demonstrated that ZNF213 associated with YAP and facilitated YAP K48-linked poly-ubiquitination at several YAP lysine sites (K252, K254, K321 and K497). Besides, the clinical data showed that ZNF213 negatively correlated with YAP protein level and Hippo target gene expression in TNBC samples. ZNF213 expression correlated with good prognosis in TNBC patients. Our data provided novel insights in YAP proteolytic regulation and TNBC progression. - Source: PubMed
Publication date: 2021/05/03
Liu YunSu PengZhao WuchenLi XinYang XiaoFan JianingYang HuijieYan ChengMao LanzhiDing YinluZhu JianNiu ZhiguoZhuang Ting - Breast cancer is the most common women malignancy worldwide, while estrogen receptor alpha positive type accounts for two third of all breast cancers. Although ER alpha positive breast cancer could be effectively controlled by endocrine therapy, more than half of the cases could develop endocrine resistance, making it an important clinical issue in breast cancer treatment. Thus, decoding the detailed mechanism, which controls ER alpha signaling activation and ER alpha protein stability, is of great importance for the improvement of breast cancer therapy. Several zinc finger proteins were shown to mediate the ubiquitination process and modulate protein stability. Thus, we further explore the function of Zinc finger protein 213 on ER alpha protein stability and tamoxifen resistance. - Source: PubMed
Publication date: 2021/03/10
Yang HuijieLv XuleiLi XinMao LanzhiNiu ZhiguoWang TingZhuang TingHuang Qingsong - Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-to-date lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for and . - Source: PubMed
Publication date: 2020/07/27
Ramilowski Jordan AYip Chi WaiAgrawal SaumyaChang Jen-ChienCiani YariKulakovskiy Ivan VMendez MickaëlOoi Jasmine Li ChingOuyang John FParkinson NickPetri AndreasRoos LeonieSeverin JessicaYasuzawa KayokoAbugessaisa ImadAkalin AltunaAntonov Ivan VArner ErikBonetti AlessandroBono HidemasaBorsari BeatriceBrombacher FrankCameron Christopher JFCannistraci Carlo VittorioCardenas RyanCardon MelissaChang HowardDostie JoséeDucoli LucaFavorov AlexanderFort AlexandreGarrido DiegoGil NoaGimenez JulietteGuler RetoHandoko LusyHarshbarger JaysonHasegawa AkiraHasegawa YukiHashimoto KosukeHayatsu NorihitoHeutink PeterHirose TetsuroImada Eddie LItoh MasayoshiKaczkowski BogumilKanhere AditiKawabata EmilyKawaji HideyaKawashima TsugumiKelly S ThomasKojima MikiKondo NaotoKoseki HaruhikoKouno TsukasaKratz AntonKurowska-Stolarska MariolaKwon Andrew Tae JunLeek JeffreyLennartsson AndreasLizio MarinaLópez-Redondo FernandoLuginbühl JoachimMaeda ShioriMakeev Vsevolod JMarchionni LuigiMedvedeva Yulia AMinoda AkiMüller FerencMuñoz-Aguirre ManuelMurata MitsuyoshiNishiyori HiromiNitta Kazuhiro RNoguchi ShuheiNoro YukihikoNurtdinov RamilOkazaki YasushiOrlando ValerioPaquette DenisParr Callum J CRackham Owen J LRizzu PatriziaSánchez Martinez Diego FernandoSandelin AlbinSanjana PillaySemple Colin A MShibayama YoutaroSivaraman Divya MSuzuki TakahiroSzumowski Suzannah CTagami MichihiraTaylor Martin STerao ChikashiThodberg MalteThongjuea SupatTripathi VidishaUlitsky IgorVerardo RobertoVorontsov Ilya EYamamoto ChinatsuYoung Robert SBaillie J KennethForrest Alistair R RGuigó RodericHoffman Michael MHon Chung ChauKasukawa TakeyaKauppinen SakariKere JuhaLenhard BorisSchneider ClaudioSuzuki HarukazuYagi Kende Hoon Michiel J LShin Jay WCarninci Piero - Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, or the congenital absence of uterus and vagina, is the most severe anomaly of the female reproductive tract. It affects 1 in 5,000 females, and is the second most common cause of primary amenorrhea. The etiology remains unknown in most patients, although four single gene defects and some repetitive copy number variants (CNVs) have been identified. Translocations in MRKH patients are very rare, and reported only in three patients previously without breakpoint mapping. We have identified the fourth MRKH translocation patient and are the first to characterize the breakpoints mapped by molecular methods. - Source: PubMed
Publication date: 2016/07/30
Williams Lacey SKim Hyung-GooKalscheuer Vera MTuck J MatthewChorich Lynn PSullivan Megan EFalkenstrom AllisonReindollar Richard HLayman Lawrence C - During our search for the familial Mediterranean fever (FMF) gene, we identified by cDNA selection a 1.2 kb cDNA fragment representing a novel human gene that is expressed in a wide variety of tissues. This gene spans approx. 8.0 kb genomic DNA and has seven exons. Its 3' untranslated region contains a long tandem repeat that gives rise to a polymorphism with two alleles of approx. 1.1 kb and 1.0 kb, with the 1.1 kb allele in strong linkage disequilibrium with FMF in patients of different ethnic backgrounds. However, both genetic and mutational analyses have excluded this gene as the one responsible for FMF. The predicted 424 amino acid protein, designated ZNF213, contains three C2H2 zinc fingers, a Kruppel associated A box and a leucine rich motif (LeR domain/SCAN box), strongly suggestive of a transcription factor. - Source: PubMed
Chen XHamon MDeng ZCentola MSood RTaylor KKastner D LFischel-Ghodsian N