ZIC4 Mouse Monoclonal Antibody
- Known as:
- ZIC4 Mouse Monoclonal Antibody
- Catalog number:
- TRA-084107-M05
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- ZIC4 Mouse Monoclonal Antibody
Related genes to: ZIC4 Mouse Monoclonal Antibody
- Gene:
- ZIC4 NIH gene
- Name:
- Zic family member 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-03
- Date modifiied:
- 2013-01-08
Related products to: ZIC4 Mouse Monoclonal Antibody
Related articles to: ZIC4 Mouse Monoclonal Antibody
- Paraneoplastic neurological syndromes (PNS) associated with triple-negative breast carcinoma (TNBC) are exceptionally rare. We report a case of fulminant encephalitis in a middle-aged woman with TNBC presenting with concurrent PNMA2 (Ma2/Ta), ZIC4 and recoverin antibody positivity. The patient initially developed a subacute cerebellar syndrome characterised by downbeat nystagmus, gait ataxia and diplopia. Comprehensive evaluation revealed FDG-avid left axillary lymphadenopathy and biopsy confirmed high-grade TNBC with PD-L1 CPS of 77. She received neoadjuvant chemo-immunotherapy as per standard institutional protocol (paclitaxel, carboplatin, epirubicin, cyclophosphamide and pembrolizumab). Following the sixth cycle, she developed refractory focal seizures progressing to status epilepticus with MRI findings consistent with cortical encephalitis. Despite aggressive immunosuppression including corticosteroids, intravenous immunoglobulin and rituximab, her condition proved refractory. She ultimately succumbed despite maximal supportive care. This case illustrates a rare paraneoplastic overlap syndrome combining PNMA2-associated encephalitis and ZIC4-associated cerebellar degeneration in TNBC, highlights diagnostic challenges when immune checkpoint inhibitors may amplify pre-existing onconeural immunity and underscores the dismal prognosis of intracellular antibody-mediated neurological syndromes despite aggressive immunotherapy. - Source: PubMed
Publication date: 2026/07/13
Gautam Roy PrabhatJagtap Aniket BGogia Ajay - - Source: PubMed
Publication date: 2025/12/29
Çiçek SultanYıldırım MiraçBektaş ÖmerTeber Serap - Dandy-Walker malformation (DWM) is a condition characterized by a cyst in the posterior cranial fossa contiguous with the fourth ventricle, combined with complete or partial agenesis of the cerebellar vermis; and elevation of the cerebellar tentorium, torcular Herophili, and transverse sinuses. DWM has been linked to specific genetic variants, with pathogenic or likely pathogenic variants reported in FOXC1, ZIC1, and ZIC4. Variants in the TUBB2B and TUBB3 genes are associated with abnormalities in tubulin, leading to cerebellar hypoplasia. In our study, three patients diagnosed with DWM underwent whole-genome analysis using next-generation sequencing, and two were found to have heterozygous variants in the tubulinopathy-associated genes TUBB2B and TUBB3, respectively. These findings indicate that some cases previously diagnosed as DWM may fall under the spectrum of tubulinopathies associated with cerebellar hypoplasia. - Source: PubMed
Publication date: 2026/06/17
Ueno KatsuyaHigasa KoichiroHayashi MikioIsozaki HarunaMiyata MayukoNaito NobuakiLi YiTakeda JunichiNonaka Masahiro - - Source: PubMed
Publication date: 2026/05/26
Ros González IChavarría-Miranda AGonzález Folgueral CPedraza Hueso M - ZIC1 encodes a transcription factor with critical roles in vertebrate neural and skeletal development. Heterozygous deletions encompassing ZIC1 and ZIC4 cause Dandy-Walker malformation, whilst in the final exon heterozygous ZIC1 variants result in a distinct phenotype of craniosynostosis with variable intellectual disability via a gain-of-function mechanism. We describe the largest group of individuals harboring ZIC1 variants to date, significantly expanding the phenotypic spectrum and allowing genotype-phenotype correlation. - Source: PubMed
Publication date: 2026/04/22
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