TIMP2 Mouse Monoclonal Antibody
- Known as:
- TIMP2 Mouse Monoclonal Antibody
- Catalog number:
- ENZ-007077-M03J
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- TIMP2 Mouse Monoclonal Antibody
Related genes to: TIMP2 Mouse Monoclonal Antibody
- Gene:
- TIMP2 NIH gene
- Name:
- TIMP metallopeptidase inhibitor 2
- Previous symbol:
- -
- Synonyms:
- CSC-21K
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-18
- Date modifiied:
- 2016-10-05
Related products to: TIMP2 Mouse Monoclonal Antibody
Related articles to: TIMP2 Mouse Monoclonal Antibody
- Acute kidney injury (AKI) is frequent in critically ill neonates and children, increasing morbidity and mortality. Early distinction between functional and intrinsic (structural) AKI is crucial due to divergent management strategies. While urinary calprotectin shows promise in differentiating AKI, urinary tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding-protein 7 (IGFBP7) lack data in pediatrics. This study evaluated [TIMP-2]•[IGFBP7] ability to differentiate functional from intrinsic AKI in neonates and children. - Source: PubMed
Publication date: 2026/09/01
Feinauer Manuel JFichtner AlexanderWesthoff Jens H - The prognosis of patients with rheumatoid arthritis (RA) complicated with interstitial lung disease (ILD) is very poor. We used blood protein profiles to identify biomarkers for ILD in patients with RA. - Source: PubMed
Publication date: 2026/08/12
Furukawa HiroshiHikichi YuichiKunieda KoheiOka ShomiHiguchi TakashiShimada KotaHashimoto AtsushiKomiya AkikoMatsui ToshihiroFukui NaoshiTohma ShigetoItoh Kenji - Macrophage-based cell therapy represents a promising approach to the acute respiratory distress syndrome (ARDS) therapy. This study investigates the potential use of adoptive transfer of siRNA-modified macrophages to influence the progression of ARDS. - Source: PubMed
Publication date: 2026/08/26
Kiseleva ViktoriiaVishnyakova PolinaKosyreva AnnaKarpulevich EvgenyTsvetkov IvanMashkova OlgaKuznetsova MariaBagdasarian AidaKaryagina VictoriaKiselev IvanLokhonina AnastasiaBogoyavlenskaya AnastasiyaKudryavtsev DenisArutyunyan IrinaSoboleva AnnaRyabova AnastasiaElchaninov AndreySukhikh GennadyFatkhudinov Timur - Myopia-associated scleral remodeling is characterized by altered extracellular matrix (ECM) turnover and progressive biomechanical weakening, processes that have been increasingly linked to scleral hypoxia. Opsin 5 (OPN5), a violet light-sensitive opsin, has been implicated in ocular growth regulation, but its role in scleral fibroblasts remains largely unknown. This study investigated the expression of OPN5 in human scleral fibroblasts (HSFs) under hypoxic conditions and examined its association with remodeling-related cellular responses. - Source: PubMed
Publication date: 2026/08/10
Tang MaolanLu ShaZhou WenjunLi JianweiLi Hua - In the mare placenta, molecular mechanisms regulating extracellular matrix (ECM) collagen deposition and vascularization are not fully understood. This study evaluated: (i) gene transcription and expression of enzymes regulating collagen deposition (matrix metalloproteinases - MMP2, MMP9), and their inhibitors (TIMP1, TIMP2); (ii) gene transcription of vascular endothelial growth factor (VEGF-A) and its receptors VEGF receptor 1 and 2 (VEGFR1 and VEGFR2); and (iii) methylation pattern of these genes promoter regions (MMP2, TIMP1, TIMP2), in both placental horns (pregnant-PH and non-pregnant-NPH), of mares (n = 17). Gene transcription was analyzed by qPCR, protein expression by Western blotting, tissue protein localization by immunohistochemistry, and DNA methylation patterns by bisulfite pyrosequencing of CpG islands in gene promoter regions. Transcription of MMP2, TIMP1, and TIMP2 was upregulated in PH, whereas no differences were found for MMP9, VEGFA, VEGFR1, and VEGFR2. Increased transcription of MMP2, TIMP1 and TIMP2 genes in PH was associated with their hypomethylation, whereas its decrease in NPH was associated with hypermethylation. A positive correlation between MMP2 transcription and methylation was observed in PH, and a negative correlation for MMP2, TIMP1 and TIMP2 in NPH. An epigenetic mechanism might be involved in placenta gene regulation. Protein abundance of MMP-2, MMP-9, TIMP-1, and TIMP-2 was similar between horns. No differences were found in MMP-2/TIMP-2 and MMP-9/TIMP-1 ratios, between horns. Proteins MMP-2, MMP-9, TIMP-1, and VEGF-A were localized in trophoblast cells, and TIMP-2 in chorioallantoic membrane stroma. This study suggests a regulatory role of epigenetics on specific modulatory ECM enzymes in the mare placenta at term. - Source: PubMed
Publication date: 2026/08/19
Dos Santos Maria Inês Monteirode Carvalho Inês BessaVasconcelos ManuelDiniz PatríciaAlpoim-Moreira JoanaFradinho Maria JoãoAlexandre-Pires GraçaBettencourt ElisaSilva ElisabeteFerreira-Dias Graça