SERPINA3 Mouse Monoclonal Antibody
- Known as:
- SERPINA3 Mouse Monoclonal Antibody
- Catalog number:
- ANG-000012-M02
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- SERPINA3 Mouse Monoclonal Antibody
Related genes to: SERPINA3 Mouse Monoclonal Antibody
- Gene:
- SERPINA3 NIH gene
- Name:
- serpin family A member 3
- Previous symbol:
- AACT
- Synonyms:
- ACT
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-04
Related products to: SERPINA3 Mouse Monoclonal Antibody
Related articles to: SERPINA3 Mouse Monoclonal Antibody
- Polycystic ovary syndrome (PCOS) remains difficult to diagnose reliably, especially when clinical decisions rely heavily on ovarian morphology, which is often mis-interpreted. To address the need for more objective molecular indicators, we validated four serum proteins highlighted in earlier nLC-MS/MS based proteomic work, namely; Fibrinogen, S100A9, SERPINA3 and SERPINA6. The objective was to analyse differential expression of these proteins and evaluate the diagnostic performance by using ROC curves. - Source: PubMed
Publication date: 2026/04/23
Fatima SabeenKori Junaid AhmedVankwani SomaMirza Munazza RazaRehman Rehana - The search for new biomarkers that allow an early diagnosis in sepsis has become a necessity in medicine. This study aims to identify protein biomarkers that differentiate sepsis from non-infectious systemic inflammatory response syndrome (NISIRS), addressing the need for early sepsis diagnosis. - Source: PubMed
Publication date: 2026/04/24
Ruiz-Sanmartín AdolfoRibas VicentSuñol DavidChiscano-Camón LuisMartín LauraBajaña IvánBastida JulianaLarrosa NievesGonzález Juan JoséCarrasco María DoloresCanela NúriaFerrer RicardRuiz-Rodríguez Juan Carlos - Chronic lung allograft dysfunction significantly limits survival after lung transplantation. The obstructive phenotype bronchiolitis obliterans syndrome (BOS) is characterized by the abnormal activation of airways epithelium, fibrotic changes with excessive extracellular matrix deposition, and airway obliteration. Mast cells, through mediators such as tryptase and chymase, play a role in lung fibrosis. The proteins osteoprotegerin (OPG) and SERPIN family member A 3 (SERPINA3) have been associated with lung fibrosis progression. Tryptase-mast cells can produce OPG, while chymase interacts with SERPINA3. This study aimed to investigate if and how SERPINA3, OPG, and tryptase/chymase-positive mast cells are related to fibrotic airway obliteration and potentially show an association with BOS severity. Serum SERPINA3 levels in BOS and non-BOS were examined using ELISA. In BOS lung tissue, non-cartilaginous airways were classified into normal, partially obstructed, and completely obstructed airways. Immunohistochemistry detected SERPINA3, OPG, chymase, and tryptase. Colocalization of and interactions between SERPINA3, OPG, and tryptase were assessed by immunofluorescence, proximity ligation assay, and AlphaFold modeling. SERPINA3 serum levels in BOS patients were higher compared to non-BOS patients. A low percentage of SERPINA3 and OPG was detected in partially and completely obstructed airways. Cells positive for OPG and SERPINA3 colocalized with tryptase-mast cells in airways. OPG colocalized with SERPINA3, and they positively correlated in partially obstructed airways. In completely obstructed airways, OPG, SERPINA3, and tryptase all positively correlated with each other. These findings suggest mast cells express SERPINA3 and OPG, and these proteins potentially form a complex in lung tissue, possibly contributing to airway remodeling in BOS. - Source: PubMed
Liu Yanzhevan der Ploeg Eline ABorghuis TheoMenz R IanTimens WimVonk Judith MMelgert Barbro NGan C TjiBurgess Janette K - In acute lung injury (ALI), clinical data show that while mortality rates are similar between sexes, women require shorter ventilation times and intensive care unit stays than men, yet preclinical studies show conflicting sex-specific vulnerabilities. We reasoned that a hidden dosing bias may explain the inconsistency, as intratracheal bleomycin is scaled to body weight, even though lung mass grows more slowly than total body mass, so age-matched males, whose body mass outpaces lung growth, inevitably receive more drug per gram of lung than females. - Source: PubMed
Publication date: 2026/03/12
Gillman SamuelNgu AliceLush MichaelKarpuk NikolayHu Kevin MLisco Steven JWang Han-Jun - Recent advances have identified YWHAG as a promising synaptic biomarker, with evidence showing that the YWHAG:NPTX2 ratio strongly predicts cognitive decline and Alzheimer's disease (AD) progression independent of amyloid and tau pathology. However, the links between YWHAG and astrocytic processes-key regulators of amyloid clearance, tau phosphorylation, and neuroinflammation-remain poorly understood. A total of 530 participants were included. Levels of YWHAG and a panel of biologically relevant astrocyte-derived proteins were measured using a proximity extension assay and validated immunoassay platforms. Associations with AD biomarkers and cognition were examined using multivariable regression, longitudinal mixed-effects models, and mediation analyses. Path analysis was performed to explore the potential pathways from YWHAG through astrocytic proteins to AD pathology and cognition. We evaluated whether combining YWHAG with astrocyte-related proteins improves its predictive performance, by comparing the area under the curve (AUC) of the combined model with that of YWHAG alone. YWHAG was positively associated with glial fibrillary acidic protein (GFAP, β = 0.558, p < 0.001), vimentin (β = 0.329, p < 0.001), aquaporin-4 (AQP4, β = 0.097, p = 0.044), thrombospondin (THBS) -1 (β = 0.470, p < 0.001), and THBS2 (β = 0.285, p < 0.001), while showing negative associations with gap junction alpha-1 protein (GJα1, β = -0.161, p < 0.001) and serpin family A member 3 (SERPINA3, β = -0.350, p < 0.001). Mediation analysis indicated that certain astrocyte-related proteins may be involved in the association between YWHAG and AD pathology. Additionally, path analysis suggested a potential pathway involving YWHAG, GJα1, Aβ42, and cognitive function. The combination of YWHAG with SERPINA3 and THBS1 achieved an AUC of 0.981, outperforming YWHAG alone (AUC = 0.885). YWHAG is associated with astrocyte-related proteins, and combining them enhances its predictive accuracy for AD, highlighting its potential utility in early clinical screening. - Source: PubMed
Publication date: 2026/04/09
Zhang ZihaoHuang PengchengYang YirongWu HailunYao XueruiWang YifanYi HancunNing KuanChen YijiaWu YuheChen ZiyiShen PingpingHong DaojunHuang XiaZou Wen-Quan