PKLR MaxPab Mouse Polyclonal Antibody
- Known as:
- PKLR MaxPab Mouse Polyclonal Antibody
- Catalog number:
- CEL-005313-B01
- Product Quantity:
- 0.05ml
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- PKLR MaxPab Mouse Polyclonal Antibody
Related genes to: PKLR MaxPab Mouse Polyclonal Antibody
- Gene:
- PKLR NIH gene
- Name:
- pyruvate kinase L/R
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q22
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: PKLR MaxPab Mouse Polyclonal Antibody
Related articles to: PKLR MaxPab Mouse Polyclonal Antibody
- To investigate the clinical features, treatment, and prognosis of pyruvate kinase deficiency (PKD) caused by gene variants. - Source: PubMed
Wang WenZhao Yan-XiaWang Ling-ZhenJiang FanYang JingSun Li-RongXu Hui-Juan - Fermented foods are recognised as functional due to their health-promoting bioactive metabolites. Our previous study showed enhanced shelf-life with stable functional metabolites of soy yoghurt fermented with Leuconostoc mesenteroides strain SB1075. Building on these findings, we prepared a new batch of SB1075-fermented soy yoghurt for animal experiments and evaluated its antidiabetic potential using transcriptomic and metabolomic approaches. GC-MS profiling confirmed reproducible metabolite patterns in fermented soy yoghurt, with the putative presence of bioactive compounds including D-pinitol and myo-inositol. Soy yoghurt was administered orally (as lyophilised powder) at the doses of 100, 200, and 400 mg/kg body weight to streptozotocin (STZ)-induced diabetic Swiss albino mice for 5 weeks, with unfermented soymilk as a control. The 100 mg/kg dose produced the most pronounced metabolic improvement, markedly reduced fasting blood glucose (90.75 ± 8.72 vs 421.5 ± 28.94 mg/dL in diabetic controls, p ≤ 0.001), improving glucose tolerance, and restoring lipid and liver biochemical parameters. Transcriptomic analysis of the intestinal tissue revealed upregulation of genes associated with insulin signalling and glucose metabolism genes (Insr, Irs1, Gck, & Pklr) alongside downregulation of inflammatory mediators (Il6 and Tnf). Metabolomic profiling further indicated differential abundance of several putatively annotated metabolites linked to metabolic regulation and oxidative stress responses. Collectively, these findings suggest that fermentation of SB1075-fermented soy yoghurt enhances the functional metabolite profile and may contribute to improved glycaemic regulation in diabetic mice. However, further studies involving targeted validation and clinical investigations will be required to confirm these mechanistic insights and evaluate the translational potential of SB1075-fermented soy yoghurt as a functional dietary intervention for metabolic health. - Source: PubMed
Publication date: 2026/04/24
Bhattacharjee Maloyjo JoyrajSheikh YunusDas SushmitaBala AsisMukherjee Ashis KKhan Mojibur Rohman - Diagnosing neonatal pyruvate kinase (PK) deficiency is challenging, especially when early transfusions render conventional testing inconclusive. Genetic testing, however, is not influenced by transfusions and can provide, in most cases, a definitive diagnosis. We report two unrelated infants with symptomatic PK deficiency, both compound heterozygous for PKLR mutations, including two undescribed missense variants (c.865C>T; p.(Arg289Trp) and c.1016A>G; p.(Asp339Gly)). These cases underscore the critical role of molecular testing -particularly hereditary hemolytic anemia next-generation sequencing (NGS) panels-in confirming the diagnosis when enzymatic assays are unfeasible, further shortening time to diagnosis in congenital hemolytic anemias. - Source: PubMed
Publication date: 2026/05/12
Sakalian OliverHuguenin YoannPissard SergeAugis VanessaWeinmann LaurentFuster ValérieLagarde MarieBadour EliseAladjidi NathalieBoutin JulianDulucq Stéphanie - Thalassemia is a common disease worldwide. Oxidative stress contributes to ineffective erythropoiesis and hemolysis in β-thalassemia major (β-TM). Increasing cellular adenosine triphosphate (ATP) production by activating the activity of the pyruvate kinase (PK) may counteract oxidative stress. SNH-119014 is a novel allosteric PK activator targeting the same protein as mitapivat (AG-348), a first-in-class agent known to ameliorate anemia in thalassemia. This study aim to evluate the effects of SNH-119014 in erythroid cells from β-TM patients. - Source: PubMed
Publication date: 2026/04/23
Huang QiulinHuang YumeiPan LingyuanLiu RongrongLai Yongrong - Hereditary spherocytosis (HS) is a genetically and clinically diverse red cell membrane disorder, with limited clinical and molecular data on pediatric patients from India. - Source: PubMed
Publication date: 2026/04/23
Chakraborty AnkitaKalra ManasSachdeva AnupamKotwal JyotiLanger SabinaSaraf AmritaRana PallaviDahiya SurbhiArya VandanaAggarwal SatishPrasad Alpana