PIP5K2A Mouse Monoclonal Antibody
- Known as:
- PIP5K2A Mouse Monoclonal Antibody
- Catalog number:
- CEL-005305-M01
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- PIP5K2A Mouse Monoclonal Antibody
Related genes to: PIP5K2A Mouse Monoclonal Antibody
- Gene:
- PIP4K2A NIH gene
- Name:
- phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
- Previous symbol:
- PIP5K2A
- Synonyms:
- PIP5KIIA, PIP5KIIalpha
- Chromosome:
- 10p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-22
- Date modifiied:
- 2016-04-11
Related products to: PIP5K2A Mouse Monoclonal Antibody
Related articles to: PIP5K2A Mouse Monoclonal Antibody
- Alzheimer's Disease (AD) is among the most prevalent neurodegenerative disorders globally, yet effective early diagnostic strategies remain lacking. Advances in multi-omics technologies and the integration of artificial intelligence into medicine have created new opportunities for developing predictive models for AD. Biomarker-based models hold significant promise for enhancing early detection. In this study, we integrated multi-omics data to identify core risk genes with potential causal links to AD and developed an early diagnostic model, thereby providing a theoretical framework for precision intervention. - Source: PubMed
Publication date: 2026/03/24
Zhang YazhiLi ZiweiLi HanruiZhang Kuixing - Kongshan cattle is an indigenous breed from Sichuan Province, China, characterized by their excellent meat quality, high fertility, strong disease resistance, and remarkable environmental adaptability. However, their genomic diversity has not been systematically studied. In this work, we performed whole-genome sequencing of 30 Kongshan cattle from a breeding farm and integrated these data with 113 representative commercial and indigenous cattle breeds worldwide to investigate their population structure and genetic diversity. We further analyzed the ancestral contributions to the development of the breed. The population structure revealed that Kongshan cattle possess four types of ancestral components: East Asian indicine (0.5974), East Asian taurine (0.3464), European taurine (0.0483), and Indian indicine (0.0079). The population also exhibits high nucleotide diversity, second only to pure East Asian indicine cattle. We inferred the ancestry of each variable site in the genome and, in combination with integrated haplotype score analysis, identified candidate genes related to meat quality (, , , , and ), immunity (, , , , , , , and ), and environmental adaptability (, , , , and ). These findings provide valuable insights into the evolutionary history and ancestral origins of Kongshan cattle and contribute to the broader understanding, conservation, and sustainable utilization of indigenous Chinese cattle genetic resources. - Source: PubMed
Publication date: 2025/12/12
Bai MengmengYang KaiMa XiaohuiBian ChenqiWang WeiYi JunChen NingboLei ChuzhaoXia Xiaoting - It is of great significance to identify candidate genes and molecular markers related to the comb development, in order to accelerate comb breeding progress of yellow feathered broiler. Herein, 400 terminal male chickens of the fast-type yellow feathered broiler (60 day old on the market) were selected as the research subjects, and their genomic genetic variation information was obtained using resequencing and genome-wide association study (GWAS). We identified 4 SNPs and 80 SNPs that were significantly correlated and potentially significantly correlated with comb height. Meanwhile, 4 SNPs and 5 SNPs were potentially significantly correlated with comb thickness and comb length, respectively. Several candidate genes related to comb traits were identified, including AR, HSF3, PIP4K2A, ATF6β, NTM, LRP1, etc. Except for SNP6 (rs317557994) locus with low genetic diversity, the other 12 SNP loci have moderate genetic diversity. Linkage disequilibrium (LD) analysis showed that 13 SNP loci were not in a strong linkage state. The association analysis between single marker and comb traits showed that AA and GA at SNP1 (rs312669246) locus, CC and CT at SNP2 (rs313331126) locus, AA and GA at SNP3 (rs313205409) locus, and AA and GA at SNP4 (rs314830898) locus were the dominant genotypes for comb height. The TT and CT genotypes at SNP5 (rs312557738), AA at SNP6 (rs317557994), GG at SNP7 (rs738748642), and AA and GA at SNP8 (rs312962270) were the dominant genotypes for comb thickness. TT at SNP9 (rs313797960), AA at SNP10 (rs312371971), AA at SNP11 (rs313637016), CC and CA at SNP12 (rs738049404), and GG at SNP13 (rs3388194039) were all the dominant genotypes for comb length. In chicken breeding, it is expected to assist in improving the selection of comb traits and accelerating the generation progress of comb development by selecting dominant genotypes at SNP1-SNP13 loci and eliminating other disadvantaged genotypes. These findings provide important references for further studying the regulatory mechanisms of comb development and cultivating new high-quality broiler breeds (crossed lines) with larger comb. - Source: PubMed
Publication date: 2025/11/16
Tu YunjieXu ShenghaiLiu YifanZhang MingMa JunJu XiaojunShan YanjuJi GaigeShu Jingting - CD8+ T cells play a pivotal role in Chronic obstructive pulmonary disease(COPD) inflammatory pathogenesis. To elucidate the molecular mechanisms underlying CD8+ T cell involvement in COPD development, this study employed an integrated approach combining bioinformatics analysis with experimental validation to identify CD8+ T cell-associated marker genes, construct a diagnostic model, and evaluate their correlation with pulmonary function in COPD. Lung tissue sequencing data from COPD patients and controls were obtained from the Gene Expression Omnibus(GEO) database. Differential expression analysis was conducted using R on both bulk RNA-seq and single-cell RNA-seq datasets. LASSO regression analysis was subsequently applied to identify hub genes, followed by functional annotation through Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses. Linear regression analysis assessed correlations between key genes and pulmonary function parameters, with qRT-PCR validation performed on three lung function-associated genes using clinical samples from COPD patients and healthy controls. Our analyses identified seven CD8+ T cell-related genes (CST7, HSPA8, PXN, YPEL5, PIP4K2A, CDKN1B, PIK3IP1) that collectively formed a highly effective diagnostic model. Among these, HSPA8, PIP4K2A, and YPEL5 demonstrated significant correlations with impaired lung function in COPD patients. qRT-PCR validation confirmed PIP4K2A expression patterns in clinical samples, consistent with microarray data. These findings establish CD8+ T cell-associated biomarkers for COPD, with PIP4K2A expression showing particular relevance to lung function decline, thereby providing new molecular insights into CD8+ T cell-mediated mechanisms in COPD pathogenesis. - Source: PubMed
Publication date: 2025/11/11
Huang ShuLin ShiyaKe JunyiLei SiyuHe ZhixiongDuan Minchao - The aberrant production of extracellular matrix (ECM) in gliomas results in aggressive tumor invasion. Hyaluronic acid (HA) and increased collagen production in the glioma matrix regulate tumor cell proliferation and migration. However, the regulatory effect of these molecules on glioma cells remains unclear. In this study, we analyzed the cell migration, proliferation, and transcriptome of glioma cells on collagen and HA substrates to understand the regulation of cellular processes. We found that both U87 and primary glioma cells showed a higher proliferation level on a collagen substrate compared with a hyaluronate substrate in an AlamarBlue® assay. U87 and primary glioma cells showed higher migration velocity on collagen substrate compared with hyaluronate substrate, a substrate of mixed collagen and hyaluronate, and collagen gels. The pathways enriched among genes up-regulated on collagen substrate versus hyaluronate substrate include focal adhesion, regulation of actin cytoskeleton, ECM-receptor interaction, and PI3K-Akt signaling pathways, which are involved in the regulation of cell migration. The up-regulated differentially expressed genes (DEGs) include integrin receptors, ECM molecules such as collagen types I, IV, and VI, fibronectin, and laminins, as well as signaling pathway molecules AKT3, RAC2, PIP5K1C, PIP4K2A, and PIK3R2. We also observed the upregulation of matrix metalloproteinase (MMP) genes and components of the glycosaminoglycan degradation pathway in glioma cells on the collagen matrix compared with those on HA matrix. This study reveals the effect of collagen and HA on glioma cells at the transcriptional level and contributes to the understanding of potential targets for therapy. - Source: PubMed
Publication date: 2025/10/22
Yao LiNeupane NischalShippy Teresa