PERP Rabbit Polyclonal Antibody
- Known as:
- PERP Rabbit Polyclonal Antibody
- Catalog number:
- APO-2451
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- PERP Rabbit Polyclonal Antibody
Related genes to: PERP Rabbit Polyclonal Antibody
- Gene:
- PERP NIH gene
- Name:
- p53 apoptosis effector related to PMP22
- Previous symbol:
- -
- Synonyms:
- PIGPC1, dJ496H19.1, KCP1, THW, KRTCAP1
- Chromosome:
- 6q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-19
- Date modifiied:
- 2019-01-31
Related products to: PERP Rabbit Polyclonal Antibody
Related articles to: PERP Rabbit Polyclonal Antibody
- Chromatin Immunoprecipitation sequencing (ChIP-seq) is the method of choice to generate chromatin landscapes across genomes. The scarcity of literature on ChIP-seq and absence of a canonical "gold standard" method in mollusks and especially the Pacific oyster Magallana gigas, prompted us to compare four chromatin profiling approaches (Native-ChIP, Crosslink-ChIP, ChIPmentation and CUT&Tag) to find the most suitable method for this species. In our hands the CUT&Tag immuno-tethering method provided most robust and reproducible signal. Our findings establish CUT&Tag as a low-background and versatile method for epigenomic studies in non-model marine organisms, enabling future comparative analyses of chromatin dynamics. - Source: PubMed
Publication date: 2026/03/26
Dellong AmélieFallet ManonStenger Pierre-LouisChaparro CristianVidal-Dupiol JeremieClément JulieGrunau ChristophCosseau Céline - Polymer-ceramic hybrid composites are emerging as attractive candidates for lightweight, corrosion-resistant absorber components in solar thermal collectors; however, their adoption is constrained by the intrinsically low thermal conductivity of polymers, processing-induced anisotropic heat transport, interfacial thermal resistance at tube/laminate joints, and durability challenges under outdoor exposure. This review provides a collector-centered synthesis of polymer-ceramic hybrid materials, emphasizing the translation of composite properties into collector-level outcomes rather than conductivity enhancement alone. A structure-property-performance mapping approach is presented to connect directional thermal conductivity ((k_in-plane), (k_perp)), thermal diffusivity, heat capacity, coefficient of thermal expansion, and service temperature with collector performance parameters such as heat removal effectiveness, overall heat losses, and stagnation behavior. Ceramic fillers (e.g., boron nitride, aluminum nitride, silicon carbide, alumina) are examined for stable conduction-network formation, coating compatibility, and long-term reliability, while carbon fillers (graphite, graphene nanoplatelets, carbon nanotubes) are evaluated for combined heat spreading and solar absorption benefits, with attention to emissivity penalties. Hybrid ceramic-carbon architectures and multilayer absorber designs are identified as the most promising routes to balance thermal transport, optical selectivity (high solar absorptance and low thermal emittance), manufacturability, and durability under UV, humidity, and thermal cycling. - Source: PubMed
Publication date: 2026/03/11
Sharma Sachin KumarPradhan ReshabSharma Lokesh KumarSharma YogeshSharma MohitPal YatendraBračun DragoKlobčar Damjan - A broad spectrum of seabed deformation structures, including pockmarks and domes, related to various processes, have been observed on continental margins worldwide. This study provides the first regional-scale inventory and quantitative characterization of pockmarks and domes potentially linked to subsurface fluid-escape processes on the continental shelf and upper slope in the Gulf of Lions (NW Mediterranean). Using high-resolution multibeam bathymetry and seismic reflection data, approximately 29,000 pockmarks and domes were identified. Morphometric and seismic analyses reveal distinct groups that differ in size, shape, and spatial organization. Among them a widespread population of domes rooted on the Holocene maximum flooding surface, which represent ~ 85% of the occurrences. The remaining 15% are pockmarks, divided into five main subtypes. Spatial association of domes and pockmarks suggests a genetic relationship between dome formation and subsequent collapse (pockmarks). Machine learning-based spatial modeling extends the estimated total to ~ 80,000 between 10 and 1000 m water depth, including zones not covered by swath-bathymetric surveys. Among various controlling factors, sediment thickness, water depth, and grain-size variability exert primary controls on the distribution of pockmarks and domes. These results demonstrate that seabed deformations in the Gulf of Lions are spatially organized, reflecting the interplay between fluid-related processes, stratigraphic architecture, and sediment properties. - Source: PubMed
Publication date: 2026/03/24
Lion AndréBassetti Maria-AngelaBerné SergeJatiault Romain - Interest in clothing that reflects far infrared (FIR) radiation naturally emitted by the body during and after exercise has increased based on the assumption that this can increase arterial and venous blood flow. Indeed, in vitro and animal model research seems to report promising effects of FIR on the nitric oxide pathway and microcirculation. However, to date, there are no well controlled studies investigating the effect of FIR garments on resting microvascular and macrovascular function in humans. Thus, the aim of this study was to examine the acute effects of wearing FIR arm garments on vascular function. - Source: PubMed
Publication date: 2025/12/30
Chamoux MaximeRakobowchuk MarkGaston Anne-FleurMourot Laurent - ObjectiveThe role of the tumor suppressor p53 apoptosis effector related to PMP-22 (PERP) in breast cancer metastasis remains unclear. This study investigated PERP's role in metastatic progression, its clinical significance, and the mechanisms underlying its effects.MethodsPERP expression was assessed in breast cancer cell lines, public datasets, and 142 patient samples using real-time quantitative polymerase chain reaction (RT-qPCR), western blotting, and immunohistochemistry. In vitro migration and invasion assays as well as in vivo metastasis model were performed after PERP overexpression or knockdown in MDA-MB-231 and MCF-7 cells. The roles of activating transcription factor 3 (ATF3) and heat shock protein family A member 6 (HSPA6) were evaluated through small-interfering RNA-mediated modulation, RNA sequencing, western blotting, RT-qPCR, and chromatin immunoprecipitation.ResultsPERP expression was markedly reduced in breast cancer cells and tumor tissues compared with that in normal controls, and low PERP levels were associated with poor prognosis. PERP overexpression suppressed metastasis. Mechanistically, PERP upregulated ATF3 expression, and ATF3 bound to the HSPA6 promoter to activate its transcription. Knockdown of or eliminated the antimetastatic effects of PERP.ConclusionsPERP suppresses breast cancer metastasis by inducing ATF3, which in turn activates HSPA6 transcription. This PERP-ATF3-HSPA6 axis represents a key regulatory pathway and serves as a potential therapeutic target in metastatic breast cancer. - Source: PubMed
Publication date: 2025/12/28
Chen CaipingHan ChaoXue LiWu WanxinZhang LinLu Xiang