IRF4 Mouse Monoclonal Antibody
- Known as:
- IRF4 Mouse Monoclonal Antibody
- Catalog number:
- BIN-003662-M02
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- IRF4 Mouse Monoclonal Antibody
Related genes to: IRF4 Mouse Monoclonal Antibody
- Gene:
- IRF4 NIH gene
- Name:
- interferon regulatory factor 4
- Previous symbol:
- MUM1
- Synonyms:
- LSIRF
- Chromosome:
- 6p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-05-31
- Date modifiied:
- 2015-11-18
Related products to: IRF4 Mouse Monoclonal Antibody
Related articles to: IRF4 Mouse Monoclonal Antibody
- Lymphomatoid papulosis (LyP) is a primary cutaneous CD30+ lymphoproliferative disorder characterized by a chronic and self-healing recurrent cluster of erythematous papules or nodules on the skin of the trunk and/or extremities. The disease has an indolent clinical course with spontaneous regression or waxing and waning clinical evolution. The histopathologic spectrum of LyP is vast and may show few to numerous atypical cells immersed in a mild to intense inflammatory background. The backbone for the diagnosis is the positivity for CD30, which is one of the criteria to define this group of lymphoproliferative disorders. The association of these different histological and immunophenotypical findings is used to subclassify this disease in different subtypes from A to E, associated with DUSP22/IRF4 rearrangement, and other rare forms. Although this differentiation is important to raise awareness of different differential diagnosis, it does not impact the prognosis or change the treatment, which is usually centered in symptom relief and faster regression. In this review, we aim to summarize the most updated information of the clinical, histopathological, and molecular characteristics of LyP and provide a practical assessment for the diagnostic features that could help with the main differential diagnosis. - Source: PubMed
Publication date: 2026/07/15
Marques-Piubelli Mario LTorres-Cabala Carlos AMiranda Roberto N - Behçet's disease (BD) is a systemic vasculitis with inflammatory lesions mediated by cytotoxic T cells and neutrophils. Here, we explore the critical involvement of NF-κB signaling pathway in proinflammatory CD8+ T cells differentiation and disease progress of BD patients. - Source: PubMed
Publication date: 2026/06/29
Le Joncour AlexandreRégnier PaulMaciejewski-Duval AnnaCharles ErwanComarmond CloéBarete StéphaneVieira MatheusFouret PierreBelot AlexandreViel SébastienRosenzwajg MichelleKlatzmann DavidCacoub PatriceSaadoun David - Exhausted T cells are phenotypically and functionally heterogeneous, from progenitor- to terminally-exhausted T cells. We evaluated gene expression profile of CD8+ T cells in acute leukemia to characterize the phenotype of exhausted T cells. Blood samples were collected from acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) patients prior to treatment and from control subjects. Additionally, samples were obtained from ALL patients after induction therapy. TCF7, NFATc1, IRF4, and BATF gene expression was then evaluated in isolated CD8+ T cells. CD8+ T cells from ALL patients showed higher expression of TCF7 and NFATc1 compared to the control group. The two study groups did not have a significant difference in the expression of BATF and IRF4. When compared to the control group, CD8+ T cells of AML patients showed an elevated expression level of NAFTc1 and IRF4. Significant differences were not found between the two study groups in AML when it came to the expression of BATF and TCF7. To our findings, the majority of CD8+ T cells found in ALL patients consist of progenitor-exhausted T cells. - Source: PubMed
Publication date: 2026/06/03
Akbar ArminAsgarian-Omran HosseinValadan RezaNajafi AhmadShekarriz RaminZaboli EhsanEslami-Jouybari MohammadKarami HosseinNaderisoraki MohammadTehrani Mohsen - Interleukin-21 (IL21) is an important immunoregulatory cytokine involved in antitumor immune response; however, its cellular source, regulatory program, and functional significance in colorectal cancer remain incompletely understood. - Source: PubMed
Publication date: 2026/06/26
Lu PeiyuZhou HuaJiang HongweiWu YouYang HanlinLiu YiruiWu ShaoxianYang Min - Type 1 regulatory T (Tr1) cells are CD4 T cells with suppressive function that are induced from conventional T cells exposed to persistent or strong antigens. Human Tr1 cells are understudied; the regulators of their antigen-driven differentiation are unknown, and identifying them in tissues, where antigen interactions occur, is challenging. Here, we conducted a multiomic profiling of human antigen-induced Tr1 cells. Using CRISPR-based functional genomics, we uncovered essential roles of transcription factors IRF4, BATF, and MAF in human Tr1 differentiation, phenotype, and function. We also derived a Tr1 transcriptional signature that detects cells with a Tr1 phenotype in single-cell datasets from patients treated with Tr1 therapy and those with solid tumors. Cross-species analysis confirmed this signature identifies bona fide Tr1 cells induced in vivo in a murine solid tumor model. These findings provide a framework for development of Tr1-based and Tr1-targeting therapies and studies of Tr1 cell biology. - Source: PubMed
Publication date: 2026/07/10
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