HSD17B1 Mouse Monoclonal Antibody
- Known as:
- HSD17B1 Mouse Monoclonal Antibody
- Catalog number:
- BIN-003292-M03
- Product Quantity:
- 0.05mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- HSD17B1 Mouse Monoclonal Antibody
Related genes to: HSD17B1 Mouse Monoclonal Antibody
- Gene:
- HSD17B1 NIH gene
- Name:
- hydroxysteroid 17-beta dehydrogenase 1
- Previous symbol:
- EDHB17, EDH17B2
- Synonyms:
- HSD17, MGC138140, SDR28C1
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-05
- Date modifiied:
- 2016-06-03
Related products to: HSD17B1 Mouse Monoclonal Antibody
Related articles to: HSD17B1 Mouse Monoclonal Antibody
- Early pregnancy is a highly coordinated process requiring precise embryo-maternal communication. Estradiol-17β (E2) is considered the primary conceptus-derived signal responsible for the maternal recognition of pregnancy in pigs. Successful pregnancy establishment requires two distinct peaks of E2 secretion by porcine conceptuses: during days 11-12 (the maternal recognition of pregnancy) and days 15-30 (implantation). Although the role of E2 in signaling to the maternal system is well established, its potential autocrine effects on conceptus development remain unclear. This study examined whether E2 regulates trophoblast function during the maternal recognition of pregnancy and implantation. We demonstrated that expression of estrogen receptors (ESR1, ESR2, GPER1) and selected pregnancy-related genes (FOXO3, GDF15, SERPINE1, ESRRB, ESRRG) changes during early pregnancy in the pig. E2 regulated the gene expression of its receptors (ESR1, ESR2, GPER1), genes involved in E2 synthesis (HSD17B1), prostaglandin synthesis (PTGS2, AKR1C4, PTGES), and key mediators of pregnancy establishment (IL1B2, SERPINE1, FOXO3, GDF15, ESRRB and ESRRG). Furthermore, E2, acting via nuclear estrogen receptors, enhanced trophoblast cell proliferation on days 12 and 15 of pregnancy, and increased adhesion as well as MAPK1/3 and PTK2 protein phosphorylation on day 15 of pregnancy. E2 stimulated cell proliferation via MAPK and PI3K/AKT/mTOR pathways, whereas E2-promoted adhesion was mediated via MAPK and PI3K/AKT signaling. Concluding, these findings indicate that E2 functions not only as a critical embryonic signal for the maternal recognition of pregnancy but also plays an autocrine role in conceptus development, regulating gene expression and trophoblast cell function during early gestation in pigs. - Source: PubMed
Publication date: 2026/04/11
Goryszewska-Szczurek EwelinaWaclawik Agnieszka - The ovarian granulosa cells are responsible for producing hormones and supporting oocytes through maturation and meiotic resumption. There is a need to generate granulosa-like cells (GLCs) from human induced pluripotent stem cells (hiPSCs) to better model human gonadal development and to test the effects of exogenous or pharmaceutical compounds on the ovary. Here we report a rapid ligand-based protocol for differentiating hiPSCs into cells that express markers of the transient developmental lineages and steroidogenic pathway genes. Single-cell RNA-sequencing (scRNA-seq) analysis identified canonical granulosa cell genes were expressed in a subset of cells and identified new genes of interest that were significantly associated with computationally modeled pseudotime. HSD17B1 was expressed in resulting GLCs but at low levels, suggesting an immature granulosa cell phenotype. The GLCs were produced using a simple culture method that could be augmented for granulosa cell functions such as sustaining oocyte growth. Producing GLCs through protocols such as this one is a first step toward designing large-scale ovarian endocrinology assays and developing personalized cell-based fertility and hormone restoration technologies in the future. This rapid protocol produced cells that express steroidogenic enzyme genes etoc blurb. Kubo and colleagues present a 5-day rapid protocol to generate immature granulosa-like cells from hiPSCs. Cells differentiated with inhibition of DKK1, a WNT signaling target gene, expressed gonadal ridge markers and FOXL2 transcripts and protein. Additionally, steroidogenic enzyme genes were expressed. A small population of differentiated cells were identified as expressing early-stage granulosa cell genes by single-cell RNA-seq. - Source: PubMed
Publication date: 2026/04/01
Kubo HanaLu LinaVanZanten MayaThyagraj JanaviSaunders Diane CGao RuliLaronda Monica M - - Source: PubMed
Publication date: 2026/02/13
Ruan Guan-YuYe Li-XiangLin Jian-SongLin Hong-YuYu Li-RuiWang Cheng-YanMao Xiao-DanZhang Shui-HuaSun Peng-Ming - Sex determination and differentiation are complex processes shaped by a wide variety of molecular factors. In contrast to teleost species, many aspects of these processes remain poorly understood in basal non-teleost fishes such as the Siberian sturgeon (Acipenser baerii). Genetic sexing of this important aquaculture species now enables studies of undifferentiated males and females to identify factors involved in early sexual differentiation. - Source: PubMed
Publication date: 2026/02/02
Lasalle Gerla AndréBenech-Correa GermánKlopp ChristopheVizziano-Cantonnet Denise - The increasing global prevalence of obesity, exacerbated by factors such as high-fat diets and reduced physical activity, poses a substantial risk for lifestyle-related diseases, particularly in postmenopausal women. Premenopausal women initially have a lower incidence of cardiovascular disease than men, but this risk increases after menopause, highlighting menopause as a critical risk factor. Our previous study showed that the extract of (CM) modulates androgen metabolism partially by inhibiting the gene expression of catabolizing enzyme 5α-reductase. In this study, we investigated the effect of CM on estrogen deficiency-induced obesity in ovariectomized (OVX) mice fed a 0.1% CM diet (estimated human equivalent dose: 7.5 g/day) for 52 days. OVX mice had increased body weight, which subsequently decreased with CM, without altering daily food intake. Regarding visceral fat, CM suppressed OVX-induced adipogenic markers (, , , and and protein levels of C/EBPβ, PPARγ, and p-AKT. CM effectively reversed the OVX-induced reduction in the levels of adipose and , key enzymes involved in steroid hormone biosynthesis, increased the cellular senescence markers and and decreased expression. CM reduced the expression of oxidative stress markers HO-1, NRF2, and 4-HNE. Moreover, CM increased uterine weight and serum superoxide dismutase in 17β-estradiol-treated OVX rats. These findings suggested that CM, particularly its component cordycepin, holds promise as a natural agent for mitigating weight gain, particularly in the context of postmenopausal obesity. - Source: PubMed
Publication date: 2026/01/29
Kusama KazuyaFujii ChisakiYoshida KanokoYoshie MikihiroAdachi YoshiyukiMiyaoka HiroakiTamura Kazuhiro