DAZ1 Mouse Monoclonal Antibody
- Known as:
- DAZ1 Mouse Monoclonal Antibody
- Catalog number:
- BIN-001617-M09
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- DAZ1 Mouse Monoclonal Antibody
Related genes to: DAZ1 Mouse Monoclonal Antibody
- Gene:
- DAZ1 NIH gene
- Name:
- deleted in azoospermia 1
- Previous symbol:
- DAZ
- Synonyms:
- SPGY
- Chromosome:
- Yq11.223
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-12
- Date modifiied:
- 2015-08-27
Related products to: DAZ1 Mouse Monoclonal Antibody
Related articles to: DAZ1 Mouse Monoclonal Antibody
- Arabidopsis MYB transcription factor, AtDUO1 regulates generative cell body (GC) morphogenesis from round to semi and fully elongated forms before pollen mitosis-II (PM II). It was hypothesised that DUO1 might regulate morphogenesis through any of its direct target genes or components of the DUO1-DAZ1 network. The developmental analysis of plants harbouring T-DNA insertions in some DUO1 target genes using light and fluorescence microscopy revealed abnormal GC morphogenesis only in daz1 and daz2, but gcs1, trm16, mapkkk10, mapkkk20, tet11, and tip1 all undergo normal elongation indicating that these target genes have no important roles in morphogenesis or may be redundant. The important regulatory role of DUO1 was confirmed through the observed incomplete rescue of morphogenesis of mutant duo1-1 GCs by DAZ1 and independently by a C-terminally deleted version of DUO1 (DUO1∆C3) lacking activation sequences. The evidence supports the important role of DAZ1 in GC shape partial morphogenesis. The C-terminus of DUO1 may regulate some target genes that affect GC body elongation. Furthermore, an intact DUO1 is shown to be indispensable for GC shape and nucleus elongation and subsequently for timely division and sperm cell morphogenesis. The development of the GC cytoplasmic projection is regulated independently of DUO1, and all its target genes were able to form it. - Source: PubMed
Publication date: 2025/01/07
Rauf AbdurWang AnbangLi YujiaLian ZhihaoWei ShouxingKhan QayashJabbar KashmalaJan FarooqKhan IkramullahBibi MamoonaAbidullah SyedLi Jingyang - Cytoplasmic projections (CPs) formed by the generative and sperm cells link the male gametes with the vegetative cell (VC) nucleus, which are required to build the male germ unit (MGU) assemblage in the angiosperm pollen grain. As molecular and genetic controls underlying CP development and formation of the MGU are unknown, it was hypothesized that physical association between germ cells and the VC nucleus might be lost in () mutants or in those which either block generative cell (GC) division or that additionally prevent gamete differentiation. In vivo, analysis of marked cellular components demonstrated a linkage of sperm cells (SCs) and the VC nucleus in mutant alleles despite their increased physical separation. Similarly, for several independent classes of bicellular pollen mutants, undivided GCs were associated with the VC nucleus like GCs in wild-type pollen. We conclude that the early formation of GC CPs to establish the MGU is regulated independently of DUO1-DAZ1 and DUO3 transcription factors as well as cyclin-dependent kinase function (CDKA;1). As the absence of cytoplasmic protrusion was expected in the mutants in Arabidopsis, early histological studies reported temporal disappearance of cytoplasmic protrusion in several organisms. Our findings demonstrated the striking importance of live imaging to verify the broad conservation of the persistent MGU contact in all the angiosperms and its important role in successful double fertilization. - Source: PubMed
Publication date: 2024/07/29
Rauf AbdurWang AnbangLi YujiaLian ZhihaoWei ShouxingJabbar KashmalaWisal MuhammadKhan IkramullahKhalid MuhammadLi Jingyang - - Source: PubMed
Chen Chih-Ping - Primate-specific DAZ (deleted in azoospermia) has evolved in the azoospermia factor c (AZFc) locus on the Y chromosome. Loss of DAZ is associated with azoospermia in patients with deletion of the AZFc region (AZFc_del). However, the molecular mechanisms of DAZ in spermatogenesis remain uncertain. In this study, the molecular mechanism of DAZ is identified, which is unknown since it is identified 40 years ago because of the lack of a suitable model. Using clinical samples and cell models, it is shown that DAZ plays an important role in spermatogenesis and that loss of DAZ is associated with defective proliferation of c-KIT-positive spermatogonia in patients with AZFc_del. Mechanistically, it is shown that knockdown of DAZ significantly downregulated global translation and subsequently decreased cell proliferation. Furthermore, DAZ interacted with PABPC1 via the DAZ repeat domain to regulate global translation. DAZ targeted mRNAs that are involved in cell proliferation and cell cycle phase transition. These findings indicate that DAZ is a master translational regulator and essential for the maintenance of spermatogonia. Loss of DAZ may result in defective proliferation of c-KIT-positive spermatogonia and spermatogenic failure. - Source: PubMed
Publication date: 2024/05/23
Ou NingjingWang YuciXu ShuaiLuo JiaqiangZhang ChenwangZhang YangyiShi XiaoyanXiong MinggangZhao LiangyuJi ZhiyongZhang YuxiangZhao JingpengBai HaoweiTian RuhuiLi PengZhi ErleiHuang YuhuaChen WeiWang RuiqiJin YuxuanWang DianLi ZhengChen HaoYao Chencheng - Background: Male infertility contributes to roughly 15% of all infertility cases in couples. The most common cause of male infertility is azoospermia, which is caused by genetic mutations. The connection between various single nucleotide polymorphisms in the genes and AZF region microdeletions with male infertility has not been reported. - Source: PubMed
Jabbar Kadhim NashwahDastmalchi NargesBanamolaei ParisaSafaralizadeh Reza