DARS Mouse Monoclonal Antibody
- Known as:
- DARS Mouse Monoclonal Antibody
- Catalog number:
- BIN-001615-M01
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- DARS Mouse Monoclonal Antibody
Related genes to: DARS Mouse Monoclonal Antibody
- Gene:
- DARS NIH gene
- Name:
- aspartyl-tRNA synthetase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-22
- Date modifiied:
- 2015-09-11
Related products to: DARS Mouse Monoclonal Antibody
Related articles to: DARS Mouse Monoclonal Antibody
- A series of novel axially chiral compounds based on 3,3'-bidithieno[2,3-:3',2'-]thiophene () bearing two aryl groups (referred to as s) were synthesized and successfully resolved into their enantiomers. Crystal structure analysis confirms that aromatic substitution can significantly alter the dihedral angle of with multiple intermolecular interactions. The racemization of enantiomers s showed that their inversion barriers (ΔG) are in a range of 22.2-37.4 kcal/mol. Owing to their high chiral stability, s exhibit remarkable circularly polarized luminescence (CPL) properties. In particular, and achieve their luminescence dissymmetry factors || up to 0.011. In addition, enantiomers exhibited dual emission, circularly polarized fluorescence (CPF) and circularly polarized phosphorescence (CPP). This work provides critical theoretical insights into heterocyclic aromatic ring with axial chirality in novel CPL materials. - Source: PubMed
Publication date: 2026/04/13
Li XingyangXu WanQiu ShuaiXu LiWang Hua - Vascular vertigo is a common sequela following stroke, significantly impairing patients' quality of life and rehabilitation progress. Although Western pharmaceutical treatments are widely used, their long-term efficacy is limited and associated with side effects. Acupuncture, a traditional Chinese medical therapy, has potential advantages in alleviating vertigo symptoms. This study aims to evaluate the efficacy and central mechanisms of acupuncture for post-stroke vascular vertigo (PSVV). - Source: PubMed
Publication date: 2026/03/25
Pang LinaLi ShufangGong MengYe XiangyinGou ChunyanMao XiangXiao RenyanLi YanLi XinyiWang HongyuanJin Song - Drought, heat, and salinity severely constrain the yield and fiber quality of Gossypium hirsutum. Although abscisic acid (ABA) is a central regulator of plant abiotic stress responses, whether exogenous ABA elicits a core response shared with multiple abiotic stresses in G. hirsutum remains unclear. Here, we identified 200 μM ABA as an effective concentration for mitigating physiological damage under drought, heat, and salt stress, and integrated time-series RNA-seq, hormone profiling, and assay for transposase-accessible chromatin sequencing (ATAC-seq) to characterize ABA-induced responses. Comparative transcriptome analysis identified 3345 core differentially expressed genes (DEGs) shared among ABA, drought, heat, and salt treatments, which were enriched in circadian rhythm, photosynthesis, water homeostasis, and carbon metabolism. Hormone profiling showed rapid accumulation of ABA and ABA-glucose ester after ABA treatment, accompanied by enhanced jasmonate- and ethylene-related signals and reduced salicylic acid and gibberellin levels. ATAC-seq revealed increased promoter chromatin accessibility at 12h after ABA treatment, and accessibility changes were generally positively associated with the expression of nearby genes. Integration of shared DEGs, promoter-associated differentially accessible regions (DARs), and motif enrichment identified a candidate regulatory network consisting of 24 transcription factors (TFs) and 439 putative target genes. Functional analysis further supported Gh_MYB-D as a positive regulator associated with tolerance to multiple abiotic stresses. Together, these results provide a candidate regulatory framework for ABA-enhanced abiotic stress tolerance in G. hirsutum and nominate genes for future functional validation. - Source: PubMed
Publication date: 2026/04/08
Zhao JieyinGeng ShiweiLi ShengmeiGao WenjuWang TingweiSu XueningWang YuxiangChen QinQu YanyingChen Quanjia - - Source: PubMed
Publication date: 2026/03/31
de Macedo Beatriz AguiarKakadiya JayMaciel Rafaela CVerdan SarahAntunes VanioSair Haris ILuna Licia P - Antibody-drug conjugates (ADCs) are a rapidly expanding class of biopharmaceuticals for cancer targeted therapy, with fifteen ADCs approved for clinical use and over hundred candidates in clinical development. ADCs comprise a tumor-specific monoclonal antibody (mAb), to which a cytotoxic payload is attached via a linker. Approved ADCs are heterogeneous products encompassing a range of drug-to-antibody ratios (DARs), due to the chemical methods employed for conjugation. Achieving precise DAR control is expected to improve product homogeneity, pharmacokinetics (PK), safety, and clinical efficacy. In this study, we developed a rapid and efficient two-component bioconjugation system, comprising a recombinant peptidyl asparaginyl ligase (PAL) and a human glutaminyl cyclase (hQC), to conjugate anti-HER2 antibodies. Trastuzumab and disitamab were conjugated with single or branched payloads, yielding ADCs with DAR values ranging from 2 to 8. These ADCs demonstrated cytotoxicity comparable to their chemically conjugated counterparts, trastuzumab deruxtecan (DXd, Enhertu) and disitamab vedotin (Aidixi) against HER2-expressing breast cancer cell lines and PDX models. Notably, SGZ026, a PAL-conjugated trastuzumab-DXd with DAR 3.9, exhibited better in vivo mouse plasma stability compared to Enhertu (DAR 8). Despite carrying approximately half the cytotoxic payload per antibody, a single dose of SGZ026 effectively inhibited tumor growth in breast cancer PDX models with high or intermediate HER2 expression, achieving efficacy comparable to Enhertu. These findings highlight a novel and robust enzyme-based conjugation technology for developing homogenous ADCs with an improved therapeutic window. - Source: PubMed
Publication date: 2026/03/26
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