CYP2E1 MaxPab Mouse Polyclonal Antibody
- Known as:
- CYP2E1 MaxPab Mouse Polyclonal Antibody
- Catalog number:
- BIN-001571-B01
- Product Quantity:
- 0.05ml
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- CYP2E1 MaxPab Mouse Polyclonal Antibody
Related genes to: CYP2E1 MaxPab Mouse Polyclonal Antibody
- Gene:
- CYP2E1 NIH gene
- Name:
- cytochrome P450 family 2 subfamily E member 1
- Previous symbol:
- CYP2E
- Synonyms:
- -
- Chromosome:
- 10q26.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-03-03
- Date modifiied:
- 2015-12-09
Related products to: CYP2E1 MaxPab Mouse Polyclonal Antibody
Related articles to: CYP2E1 MaxPab Mouse Polyclonal Antibody
- As a bioactive compound of Astragalus mongholicus Bunge, cycloastragenol (CAG) has gained huge attention for its status as a telomerase activator. The evaluation of the impact of CAG on cytochrome P450 enzymes (CYP450s) may reveal potential pharmacological interactions, facilitating the development of treatment regimens using CAG or Astragalus mongholicus Bunge. - Source: PubMed
Publication date: 2026/05/08
Luo HaixiaDing Xuemin - With the improvement of people's living standards, public attention to pork quality has grown increasingly. This study aimed to identify the key genes affecting meat quality in pigs. Castrated Mashen (MS) pigs (n = 6) with an average body weight of 112.5 kg (300 days of age) and Duroc × (Landrace × Yorkshire) (DLY) pigs (n = 6) with an average body weight of 114.5 kg (165 days of age) were selected for slaughter. The longissimus dorsi muscle (LDM) was collected for meat quality traits determination and omics analyses. The results showed that MS pigs exhibited significantly superior meat color, intramuscular fat (IMF) content, marbling, shear force, and pH compared with DLY pigs (p < 0.05). A total of 1330 differentially expressed genes (DEGs), 94 differentially expressed lipids (DELs), and 185 differentially accumulated metabolites (DAMs) were screened between MS and DLY pigs (p < 0.05). Further weighted gene co-expression network analysis (WGCNA) revealed that glycerophospholipids (GP) and glycerolipids (GL) were key lipids affecting pork quality. Additionally, integration of lipidomic and metabolomic data identified "lipids-metabolites strong correlation pairs" influencing meat quality, such as the significant positive correlation between carnitine derivatives and various triglycerides (TG) (|r|> 0.8, p < 0.05). Furthermore, we conducted transcriptome-metabolome and transcriptome-lipidome correlation analyses based on expression abundance and functional annotations, and screened four key gene sets. Finally, after the intersection of these key genes, 19 core genes such as ALDOB, ASS1, CYP2A13, CYP2E1, DMGDH, PLCB1, and MAT1A may be related to pork quality. This study provides potential targets for further exploring the molecular mechanisms underlying pork quality by identifying several key genes linked to pork quality traits. - Source: PubMed
Publication date: 2026/05/09
Huo KeyanQiao MeiWang ShouyuanLiu JunjieYu JialiangSun DiHuang MengjieLiang LinLi BugaoLu ChangCao Guoqing - A recent article in this journal by Wu et al presented a comprehensive model for the maturation of paracetamol clearance from birth to adulthood using pooled plasma and urinary data of the parent drug and its metabolites from 298 subjects. The modeling showed that the oxidative bioactivation to hepatotoxic metabolite N-acetyl-p-benzoquinone imine (NAPQI) is generally around 10% of the total clearance. We would like to comment on the authors' discussion on the formation of NAPQI, which highlights once again the main role of CYP2E1 in the oxidative bioactivation metabolism of paracetamol. CYP2E1 was demonstrated as a primary catalyst in the bioactivation of paracetamol, referring only to the paper of Johnsrud et al, that describes only the developmental phase of CYP2E1 in man. - Source: PubMed
Pasanen MarkkuJuvonen Risto O - Brexpiprazole is a third-generation antipsychotic used for the treatment of schizophrenia or as an adjunctive drug for the treatment of affective and neurological disorders. The combined treatments with brexpiprazole and other drugs that are also cytochrome P450 (CYP) substrates may lead to pharmacokinetic drug-drug interactions. Our present work aimed to investigate the effects of prolonged administration of brexpiprazole on the expression of hepatic transcription factors and CYP drug-metabolizing enzymes. - Source: PubMed
Publication date: 2026/05/08
Danek Przemysław JPukło RenataDaniel Władysława A - Alcohol use disorder(AUD) is a chronic condition responsible for more than 3 million deaths annually worldwide and contributes to the development of multiple systemic comorbidities. Chronic alcohol consumption promotes inflammatory responses, immune suppression, antioxidant dysregulation, and nutritional deficiencies, severely affecting organs such as the liver and pancreas. Disruption of methionine metabolism and antioxidant defenses, including reduced availability of S-adenosyl-L-methionine (SAMe) and essential B-vitamins, has been implicated in alcohol-induced oxidative stress. Therefore, the aim of the present study was to investigate whether co-supplementation with SAMe and B-vitamins could alleviate ethanol-induced hepato-pancreatic injury by improving redox homeostasis and glutathione biosynthesis. - Source: PubMed
Publication date: 2026/04/22
Nandagopal Prasanth BabuManickam Venkatraman