CTRP2 Rabbit Polyclonal Antibody
- Known as:
- CTRP2 Rabbit Polyclonal Antibody
- Catalog number:
- CYT-3671
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- CTRP2 Rabbit Polyclonal Antibody
Related genes to: CTRP2 Rabbit Polyclonal Antibody
- Gene:
- C1QTNF2 NIH gene
- Name:
- C1q and TNF related 2
- Previous symbol:
- -
- Synonyms:
- CTRP2
- Chromosome:
- 5q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
Related products to: CTRP2 Rabbit Polyclonal Antibody
Related articles to: CTRP2 Rabbit Polyclonal Antibody
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Valizadeh Laktarashi HosseinRahimi MiladAbrishamifar KimiaMahmoudabadi AliNazari Elham - Osteoarthritis (OA) is one of the most prevalent chronic conditions and significantly contributes to local and global disease burden. Common pharmaceuticals that are used to treat OA cause significant side effects, thus non-pharmaceutical bioactive alternatives have been developed that can impact OA symptoms without severe side-effects. One such alternative is the Red Algae species (Litho). However, there is little mechanistic knowledge of its potential to effect OA gene expression, and a human in vitro model using commercially available cell lines to test its effectiveness has yet to be developed. Human osteoblast (hFOB 1.19. CRL-11372) and chondrocyte (C28/I2) cell lines were co-cultured indirectly using transwells. IL1-β was used to induce an inflammatory state and gene expression profiles following treatment were the primary outcome. Results indicated that the model was physiologically relevant, remained viable over at least seven days, untreated or following induction of an inflammatory state while maintaining hFOB 1.19. and C28/I2 cell phenotypic characteristics. Following treatment, Litho reduced the expression of inflammatory and pain associated genes, most notably , , () and (). Confirmatory analysis with droplet digital PCR (ddPCR) revealed that Il-1β induced a significant reduction in at 7 days which was ameliorated with Litho treatment. These data present a novel and replicable co-culture model of inflammatory OA that can be used to investigate bioactive nutraceuticals. For the first time, this model demonstrated a reduction in expression that was mitigated by Red Algae species. - Source: PubMed
Publication date: 2025/02/24
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