CPB1 Mouse Monoclonal Antibody
- Known as:
- CPB1 Mouse Monoclonal Antibody
- Catalog number:
- BIN-001360-M01
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- CPB1 Mouse Monoclonal Antibody
Related genes to: CPB1 Mouse Monoclonal Antibody
- Gene:
- CPB1 NIH gene
- Name:
- carboxypeptidase B1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1992-04-13
- Date modifiied:
- 2015-12-16
Related products to: CPB1 Mouse Monoclonal Antibody
Related articles to: CPB1 Mouse Monoclonal Antibody
- TP53 mutations are commonly observed in aggressive subtypes of breast cancer, influencing the tumor microenvironment (TME) and patient prognosis. In this study, we developed a prognostic gene-based risk model to stratify TP53-mutant breast cancer patients and explore potential therapeutic targets. - Source: PubMed
Publication date: 2025/09/30
Paulino Peter Jerome Ishmael VChe Omar Mohammad Tasyriq - This study explores the potential molecular mechanisms underlying the pathogenesis of gastric cancer induced by plasticizers, with particular emphasis on the interactions between plasticizers and key genes and signaling pathways. Methods: Machine learning algorithms were applied to multiple public datasets to identify potential target genes associated with gastric cancer. The interactions between plasticizers and target proteins were explored using network toxicology and molecular docking. Results: Our analysis identified 17 gastric cancer-related target genes associated with plasticizer exposure. Through machine learning optimization, the RF + Lasso model demonstrated superior performance (AUC: 0.816) and identified six core genes: CPB1, AKR1C1, GRM2, CA2, MMP7, and TDO2. Differential expression analysis revealed upregulation of GRM2, MMP7, and TDO2, alongside downregulation of CPB1, AKR1C1, and CA2 in gastric cancer tissues. Molecular docking confirmed specific binding interactions between plasticizers and target proteins, with binding energies ranging from − 6.4 to -11.2 kcal/mol. Conclusion: Our findings indicate that plasticizers may drive gastric cancer tumorigenesis by modulating key genes and signaling pathways. The molecular docking results indicate that there may be specific binding interactions between the target protein and plasticizers. This research establishes a platform for further probing the impact of plasticizers on gastric cancer development, offering conceptual guidance for forthcoming functional validation and targeted therapy development. - Source: PubMed
Publication date: 2025/12/02
Guo RuiMa WeifengRen ZhiLi DapengWang MengXu MingtaoZheng HailunKe Xiquan - Human papillomaviral (HPV) integrations into host human genome, a frequently observed event in HPV associated cervical cancer, are currently mapped through expensive Whole Genome sequencing (WGS) or RNA sequencing (RNA-seq) methodologies. This study aims to develop a targeted sequencing assay to determine HPV integrations in cervical tumors without the need for WGS or RNA-seq. We employed a library preparation strategy using tiled single primers that bind to HPV genome as a template and possibly extend HPV sequences into adjacent host human genomic sequences resulting in HPV and human chimeric sequences. Using this strategy, we sequenced known HPV integrations in HPV18 positive HeLa and HPV16 positive SiHa cell lines. We further used this method to detect HPV integration sites in four HPV-positive cervical cancer patients and confirmed these integration breakpoints by WGS and Sanger sequencing. Functional impact of HPV integrations was explored through differentially expressed genes within or near topologically associating domain (TAD) boundaries, possibly disrupted by respective integration events in these patients. We found ZFP36L1, CPA3, CPB1 and CXCL8 as some of the differentially expressed genes within disrupted TADs, which are known cancer associated genes. Our approach also reduced the cost of HPV integration detection by 90 % compared to WGS while also minimizing sequencing data volume. We believe that this method captures HPV integrations at significantly reduced costs and lesser sequencing data volume leading to better understanding of disease progression and monitoring cancer treatment. - Source: PubMed
Publication date: 2025/07/17
Parida PreetiparnaMukherjee NiveditaSingh AgastyaLewis ShirleySharan KrishnaMallya SandeepSingh AshimaDas Surya SarathiRao MahadevHigginson Daniel SSabarinathan RadhakrishnanDamerla Rama Rao - Weaning represents a critical period during which mammals adapt to solid food and develop their immune systems. The intestine, as the primary digestive and immune organ, is central to successful weaning. Bats are the only flying mammals and undergo ontogenetic shifts in flight and diet in response to substantial energy and immune demands. However, the transcriptomic and metabolomic changes in bat intestines during the weaning transition remain unexplored. - Source: PubMed
Publication date: 2025/07/01
Li ZixuanGuo WeiChu YujiaTan XiaoWang HuiFeng JiangLiu Tong - Cyp1a (cytochrome P450 1 A) is critical for metabolizing endogenous substances and environmental chemicals. In this study, a zebrafish strain KI (cyp1a:mcherry), exhibiting low cyp1a gene expression, was compared with wild-type zebrafish (WT) to investigate the effects of cyp1a on growth and hypoxia tolerance. The results demonstrated that low cyp1a expression significantly inhibited zebrafish growth and reduced hypoxia tolerance. Specifically, KI zebrafish exhibited slower growth rates and higher sensitivity to low oxygen conditions compared to WT. These physiological phenotypes directly link low cyp1a expression to impaired growth and reduced environmental adaptation. Transcriptomic analysis revealed potential mechanisms underlying these effects, including up-regulation of digestive system-related genes (e.g., cpa1, cpb1) and dysregulation of pathways involved in detoxification, stress response, and steroid biosynthesis. These findings highlight the importance of maintaining normal cyp1a expression for healthy growth and environmental adaptation in zebrafish. - Source: PubMed
Publication date: 2025/03/19
Li MinWang DongjieHuang XiaopingWang ShulanChen ZhenhanJunaid MuhammadXie Shaolin