CIDE_A Rabbit Polyclonal Antibody
- Known as:
- CIDE_A Rabbit Polyclonal Antibody
- Catalog number:
- APO-2089
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- CIDE_A Rabbit Polyclonal Antibody
Related genes to: CIDE_A Rabbit Polyclonal Antibody
- Gene:
- CIDEA NIH gene
- Name:
- cell death inducing DFFA like effector a
- Previous symbol:
- -
- Synonyms:
- CIDE-A
- Chromosome:
- 18p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-15
- Date modifiied:
- 2018-10-08
Related products to: CIDE_A Rabbit Polyclonal Antibody
Related articles to: CIDE_A Rabbit Polyclonal Antibody
- : Promoting white adipose tissue (WAT) browning into thermogenic beige adipocytes is a promising anti-obesity strategy. (YST) has been used traditionally to alleviate obesity-related conditions. Catalpol and rhoifolin are major bioactive components of (Gaertn.) and (Thunb.) with known metabolic or anti-inflammatory effects. However, their direct roles in adipocyte browning and the mechanisms via β3-adrenergic receptor (β3-AR) signaling are not well defined, and this study addresses this gap. : To evaluate browning potential, 3T3-L1 adipocytes were treated with catalpol and rhoifolin during differentiation. The expression of browning markers and lipid metabolism or catabolism transcription factors was analyzed using Western blotting and quantitative real-time polymerase chain reaction. The involvement of the β3-AR and adenosine monophosphate-activated protein kinase (AMPK) signaling pathways was further validated using specific agonists and antagonists. : Both compound treatments significantly upregulated beige-specific (, , , , , ) and mitochondrial biogenesis markers (, , ), accompanied by a marked increase in thermogenic markers (UCP1, PGC-1α, ). Concurrently, lipolysis-related genes such as , , and were elevated, while lipogenesis targets (, , , ) were downregulated through activation of the β3-AR signaling pathway. : These findings suggest that catalpol and rhoifolin, key phytochemicals of YST, promote WAT browning and lipolysis. Our findings indicate that these compounds induce browning and modulate metabolism via the β3-AR pathway. These results serve as a cornerstone for natural anti-obesity therapy, pending further validation in vivo and clinical studies. - Source: PubMed
Publication date: 2026/05/18
Choi Seung MinLim Sung HoLee Ho SeonChoi GayoungKim Myeong JiKim HyunwooChoi Chang-Ik - Aneurysm progression is associated with complex molecular alterations that are insufficiently studied at transcriptomics level. An aneurysm is characterized as a bulge or a weak spot in a blood artery's wall that causes the vessel to abnormally enlarge or balloon, exceeding 50% of its normal diameter. In the present study aneurysm RNA sequencing (RNA-Seq) dataset involving 14 samples, which include 7 controls and 7 treatments was selected for the analysis. Pathway analysis showed the involvement of key genes in major shifts within lipid metabolism pathways. The protein-protein interaction (PPI) network analysis using the STRING database identified key hub genes that were significantly differentially expressed, including LIPE, SREBF1, SCARB2, LPL, PNPLA2, UCP1, CIDEC, DGAT2, CIDEA and FABP4. These key gene-encoded proteins may be prominent drug targets for future interventions aimed at treating aneurysms. - Source: PubMed
Publication date: 2026/03/31
Lois G ShirleyMurugan ShanmugapriyaJaganathan Mohana ShanmugamS Dhanush KumarJ Jino Blessy - The increasing demand for portable electronics and electric vehicles has made the development of advanced electrochemical energy storage systems essential. Lithium-ion batteries (LIBs), which predominantly use graphite anodes, face limitations in capacity and performance at high current rates. As a result, alternative anode materials such as tin (Sn) and antimony (Sb) have gained attention for both LIBs and sodium-ion batteries (SIBs) as well, due to their high theoretical capacity. However, their practical application is hindered by significant volume expansion during cycling, leading to electrode degradation. This study presents a novel approach to improve the stability and performance of Sn and Sb anodes by incorporating them into a laser-induced graphene (LIG) matrix. LIG was synthesized via laser ablation of a polyimide precursor mixed with metal-salt precursors, directly onto a copper current collector, enabling the in situ formation of Sn and Sb metallic nanoparticles (NPs) and SnSb alloy NPs, embedded in a few graphene layers. The localized high-temperature generated by the laser facilitated nanoparticle formation while simultaneously creating a protective carbon shell around the NPs, mitigating volume expansion and enhancing electrochemical stability. Electrochemical testing demonstrated that the LIG-metal composites exhibited superior performance compared to bare LIG in both LIB and SIB. LIG-Sn composite achieved the specific capacity of 380 mAh g in LIBs and 155 mAh g in SIBs after 80 and 50 cycles, respectively. These results highlight the potential of LIG-based Sn and Sb composites as scalable, binder-free anode materials for next-generation rechargeable batteries. - Source: PubMed
Publication date: 2026/04/29
Vezzoni VincenzoSetti MicheleMagnani GiacomoFornasini LauraScaravonati SilvioRinaldi AlessiaAhmad NiyazPasetti LorenzoBersani DaniloBertoni GiovanniSidoli MicheleGenovese GioeleRiccò MauroPontiroli Daniele - Gastric cancer (GC) poses a significant health threat, and alterations in Fatty acid β-oxidation (FAO) may influence its progression. However, the precise mechanisms underlying this association remain unclear. FAO-related genes were analyzed using transcriptomic datasets from databases of GEO and TCGA. Totally 160 FAO-associated genes were identified, and a risk scoring model was subsequently established to stratify patients into groups of low- and high-risk. Immune characteristics, drug sensitivities, and hub genes, including IL-6, were assessed. Subsequently, immunoblotting and immunohistochemistry were performed on GC cell lines and tissue samples to evaluate IL-6 expression. Analysis of the TCGA and GEO databases revealed a FAO-related gene signature comprising ACADS, ACO2, CPT2, SLC22A5, AOC3, CD36, CIDEA, G0S2, GABARAPL1, and SERINC1. We also examined gene mutations and constructed a prognostic risk scoring model with validation achieved through a nomogram to predict gastric cancer risk. Immune infiltration analysis and drug sensitivity testing (e.g. AG-014699, Axitinib, BX-795, and Cisplatin) were also conducted. IL-6 emerged as a core gene with significant expression difference across cellular and tissue levels. FAO plays a critical role in the prognosis of GC, and IL-6 may serve as a key biomarker for diagnosis and therapeutic strategies. - Source: PubMed
Publication date: 2026/05/02
Qu ChaoYuan XuetaoYang ShutingQiao YifanZhang RenjianzhiWu YunhuaZhu MengkeDu JiayinLi GanZhang RuiSun XuejunLi Xuqi - Circadian disruption exacerbates type 2 diabetes mellitus (T2DM). Time-restricted feeding (TRF) and exercise (EX) improve metabolic health, but their combinatory effect remains unclear. This study investigated whether combined TRF and EX additively ameliorates metabolism via circadian reprogramming in db/db mice. - Source: PubMed
Publication date: 2026/04/11
Li QingxinZhang GuodongZhou SugaoXie Yanli