CFL2 Mouse Monoclonal Antibody
- Known as:
- CFL2 Mouse Monoclonal Antibody
- Catalog number:
- BIN-001073-M03
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- CFL2 Mouse Monoclonal Antibody
Related genes to: CFL2 Mouse Monoclonal Antibody
- Gene:
- CFL2 NIH gene
- Name:
- cofilin 2
- Previous symbol:
- -
- Synonyms:
- NEM7
- Chromosome:
- 14q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-07-11
- Date modifiied:
- 2019-04-23
Related products to: CFL2 Mouse Monoclonal Antibody
Related articles to: CFL2 Mouse Monoclonal Antibody
- Prenatal myogenesis establishes the cellular and regulatory framework that determines postnatal muscle mass and contractile performance, and represents a critical period for elucidating mechanisms underlying developmental myopathies and impaired fetal growth. In this study, integrated single-cell transcriptomic and chromatin accessibility profiling was applied to compare the regulatory landscapes between growth-restricted and normal porcine embryonic somites. This analysis uncovered a distinct pathogenic myoblast population characterized by co-expression of netrin-5 ( ) and limbic system-associated membrane protein ( ), markedly enriched in growth-restricted embryos. These NTN5 LSAMP myoblasts exhibited a cell-autonomous differentiation blockade accompanied by coordinated epigenetic and metabolic dysregulation. Chromatin landscapes revealed sustained accessibility at the cytoskeletal regulator tropomyosin-3 ( ), suppressed accessibility at the muscle-specific actin depolymerization factor cofilin-2 ( ), and transcriptional programs consistent with impaired glycolytic flux. Perturbation of the Hippo/TGF-β signaling pathway, together with disrupted ligand-receptor interactions, exacerbated the differentiation arrest. Reconstruction of a multi-omics regulatory network delineated the mechanisms underlying aberrant embryonic myogenesis, identifying and as key regulators of porcine skeletal muscle development. Collectively, these findings define mechanistic determinants of impaired fetal myogenesis and provide candidate targets for therapeutic intervention in growth restriction as well as molecular strategies for optimizing muscle accretion in livestock. - Source: PubMed
Xu RongWang Xiao-YuFeng Zhi-TingCai Shu-FangLiang Zi-YunPan Li-PingZhou Qing-ShuangLiu Xiao-HongChen Yao-ShengMo De-Lin - Tamoxifen-induced chemoresistance promotes cancer cell survival, progression, and metastasis. Therefore, we investigated and validated tamoxifen resistance involvement in cancer progression. - Source: PubMed
Publication date: 2026/03/10
Bisht Vinod SinghKumar DeepakVats DrishiyaNayak DebasisAmbatipudi Kiran - The protective effects of acupuncture on myocardial injury have been identified in clinical trials. However, there is still a lack of comprehensive understanding of its fundamental mechanism. This research aimed to clarify the roles of plasma exosomes in the cardioprotection of acupuncture. - Source: PubMed
Zhao YueWang YingGuo ChunrongSun QiyuMi JinxiaLu PingpingShao ShuijinLu RongGuo HaidongWang Qiangli - Overactive bladder (OAB) in men with bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) represents a major therapeutic challenge, as symptoms often persist even after surgical relief of obstruction. The underlying molecular mechanisms, however, remain poorly defined. The aim of this study was to identify differentially expressed proteins in the urothelial tissues of patients with BOO-related OAB using a proteomic approach. - Source: PubMed
Publication date: 2025/12/31
Lee Sang-YeopLee Ji YongYun Sung HoLee MinjiLee Dong-EonMin Ji-HyeonLee Chung LyulKim Gun-HwaShin Ju Hyun - Breast cancer (BC) remains a significant threat to human health, with substantial variations in prognosis and treatment responses. Intra-tumor heterogeneity (ITH) presents a critical challenge in developing reliable prognostic models. - Source: PubMed
Publication date: 2025/09/26
Shen HaixingZheng QingPan JieJin YukaiZheng XiaohongYuan QingyueTan DaZhou QiangWang JingzhiSun Tianmiao