AKT1 Mouse Monoclonal Antibody
- Known as:
- AKT1 Mouse Monoclonal Antibody
- Catalog number:
- APO-000207-M07
- Product Quantity:
- 0.1mg
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- AKT1 Mouse Monoclonal Antibody
Related genes to: AKT1 Mouse Monoclonal Antibody
- Gene:
- AKT1 NIH gene
- Name:
- AKT serine/threonine kinase 1
- Previous symbol:
- -
- Synonyms:
- RAC, PKB, PRKBA, AKT
- Chromosome:
- 14q32.33
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: AKT1 Mouse Monoclonal Antibody
Related articles to: AKT1 Mouse Monoclonal Antibody
- Clear cell renal cell carcinoma (ccRCC) is distinguished by the absence of definitive diagnostic markers and efficacious treatment modalities, factors that collectively contribute to its unfavorable clinical prognosis. The targeting of senescent cells has recently emerged as a promising therapeutic strategy. Nevertheless, the precise role of cellular senescence in the pathophysiology of ccRCC has yet to be comprehensively elucidated. This study sought to investigate the role of cellular senescence levels in ccRCC through comprehensive transcriptomic, proteomic, spatial transcriptomic, and single-cell analyses. The study determined that elevated levels of cellular senescence contribute to a suppressed immune microenvironment, thereby exacerbating the prognosis for ccRCC patients. We utilized an extensive array of machine learning algorithms, in conjunction with multi-omics technologies, validated through immunofluorescence, RT-qPCR, and additional techniques, to collectively identify FLT1 as a pivotal single gene driving ccRCC progression. Our work reveals a FLT1-centered network of related factors, where FLT1 acts as the core single gene, closely associated with key factors VEGFA and AKT1. This network mediates crosstalk between endothelial and epithelial cells: endothelial cells expressing FLT1 alone, AKT1 alone, or co-expressing FLT1/AKT1 exhibited enhanced malignancy; among epithelial cells, proximal tubular epithelial cells with high VEGFA expression (a factor closely related to FLT1) represented the most aggressive subtype and acted as "pioneer cells" driving tumor progression. This FLT1-centric mechanism is evolutionarily conserved, as validated in mouse single-cell datasets. Clinically, ccRCC patients with low expression of the FLT1-centered network (particularly low FLT1) showed better responses to immunotherapy. For patients with high FLT1 expression, a combination therapy targeting this network-screened via molecular docking and dynamics simulations-may improve prognosis. This includes FLT1 inhibitors (Sorafenib, Regorafenib, Lenvatinib), supplemented by AKT1 inhibitors (Capivasertib) and VEGFA inhibitors (Bevacizumab) to suppress FLT1-associated malignant cell populations. - Source: PubMed
Sun MouyuanMao HuchaoLuo YaxianYang MeiHe ZhixuLi ShuangyangLiu ZhichaoPeng LianjieZhang QuanjieZhang JingyuZhang Yan - Acetaminophen (APAP) overdose causes acute liver injury (ALI) by triggering regulated hepatocyte death. While Imperata cylindrica (Imperatae Rhizoma) (IR) is used in traditional medicine for its hepatoprotective effects, its active compounds and their capacity to modulate this pyroptotic switch remain unknown. In the present study, friedelin (FRI) and 6-methoxyflavone (6-METH) were identified as the principal active compounds of IR, and their protective effects against APAP-induced ALI were evaluated in vivo and in vitro. The results showed that both FRI and 6-METH significantly ameliorated APAP-induced liver injury and reduced hepatocyte death. Mechanistically, their hepatoprotective effects were associated with AKT1-dependent activation of the PI3K/AKT pathway, accompanied by suppression of Caspase-3/ Gasdermin E (GSDME) signaling and attenuation of apoptosis and pyroptosis. Moreover, pharmacological inhibition or genetic silencing of AKT1 markedly weakened these protective effects. Taken together, these findings suggest that FRI and 6-METH are major hepatoprotective constituents of IR and that modulation of the AKT1-mediated Caspase-3/GSDME pathway may contribute to their protective actions against APAP-induced ALI. These findings validate its active compounds as promising therapeutic leads for ALI. - Source: PubMed
Publication date: 2026/04/15
Wu PingtingChen WeilaiLi JieXing JiayiWu HaoteTong JingyangChen PingTong HaibinChen YongpingPan Chenwei - Post stroke cognitive impairment (PSCI) is one of the most common complications of stroke, mainly manifested as learning and memory impairment in patients. Various mechanism attribute to the onset PSCI, such as cerebral small vessel disease, lesions in neuroanatomical structures, neuroinflammation and oxidative stress. Scutellariae Radix (SR), a traditional Chinese herbal medicine, has long been used for its anti-inflammatory and antioxidant properties in various diseases. - Source: PubMed
Publication date: 2026/04/11
Yao JinzhongLi YingzhiYuan Ruixia - Salix caprea L., an important medicinal plant within the family Salicaceae, holds significant value in traditional medical systems. To date, 82 compounds have been isolated and identified from this plant, including flavonoids (32 compounds, 39.02%), volatile components (19 compounds, 23.17%), and organic acids (16 compounds, 19.51%), along with salicin derivatives (8 compounds) and terpenoids (7 compounds). This review synthesizes the research progress on the phytochemical profile and pharmacological effects of Salix caprea. It analyzes the bioactivities of its various components and correlates the structural features of its flavonoids, salicin derivatives, and organic acids with their pharmacological activities, such as antioxidant and anti-inflammatory effects mediated by acting on targets like COX-2 and AKT1. Furthermore, it discusses the mechanisms through which these components exert their effects by modulating key molecular targets. Addressing current research limitations, such as unclear synergistic mechanisms, insufficient toxicological data, and a lack of quality control standards, this paper proposes key directions for future research. It suggests deepening investigations into molecular mechanisms and in vivo efficacy evaluations, improving safety assessment systems, and exploring modern pharmaceutical technologies like nano-delivery systems. This review aims to provide a scientific basis for the modern development and evidence-based medical application of this traditional medicinal plant. - Source: PubMed
Jianhua HeQingzhe ZhaoJingwen ZhangXijie ZhaoLiu HaipengNijat Dilaram - Herpes simplex virus 1 (HSV-1) infection contributes to immunopathogenic diseases and lacks an effective vaccine. Improving antigen presentation is key to better vaccine strategies and more robust immune responses. Here, we show that optineurin (OPTN), an autophagy receptor traditionally involved in protein recycling, unexpectedly stabilizes RICTOR (mechanistic target of rapamycin complex 2 [mTORC2]), a crucial step in enhancing MHC class II surface expression in dendritic cells. OPTN regulates the AKT/mTOR/signal transducer and activator of transcription 3 (STAT3) pathway, with the AKT2 isoform playing a central role. Using single-cell RNA sequencing (scRNA-seq) and transgenic mouse models, we identify the mechanistic details of this pathway. Dysregulation impairs antigen presentation, weakening immunity and vaccine efficacy. Our findings uncover a previously unknown function of OPTN and highlight its role in coordinating innate and adaptive immune defenses, with implications for vaccine development and immune response modulation in HSV-1 and other viral and bacterial diseases. - Source: PubMed
Publication date: 2026/04/16
Kadam RashmiPatil ChandrashekharFeferman LeonidMaienschein-Cline MarkChlipala GeorgeBorole PiyushBhattacharya IlinaOrameh ChimaNyugen TaraTseng HenryShukla Deepak