Dog Tissue Frozen Sections Skin
- Known as:
- Dog Tissue Frozen Sections Skin
- Catalog number:
- DF-101
- Product Quantity:
- 10 slides
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- Dog Tissue Frozen Sections Skin
Related genes to: Dog Tissue Frozen Sections Skin
- Gene:
- CCL27 NIH gene
- Name:
- C-C motif chemokine ligand 27
- Previous symbol:
- SCYA27
- Synonyms:
- ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-30
- Date modifiied:
- 2016-10-05
Related products to: Dog Tissue Frozen Sections Skin
(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat)
(Ser140)-Lipophilin (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat), (Ser140)-PLP (139-151(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated) (human, bovine, dog, mouse, rat) Salt Trifluoroacetate Binding _ Synonym (Ser140)_Lipophilin (139_151) (depalmitoylated) (human, bovi(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated) (human, bovine, dog, mouse, rat) Salt Trifluoroacetate Binding _ Synonym (Ser140)_Lipophilin (139_151) (depalmitoylated) (human, bovi(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated) (human, bovine, dog, mouse, rat) Salt Trifluoroacetate Binding _ Synonym (Ser140)_Lipophilin (139_151) (depalmitoylated) (human, bovi(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated) (human, bovine, dog, mouse, rat) Salt Trifluoroacetate Binding _ Synonym (Ser140)_Lipophilin (139_151) (depalmitoylated) (human, bovi(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated), human, bovine, dog, mouse, rat(Tyr0)-C-Peptide (dog) 98% C146H234N38O51 CAS: 101135-67-5(Tyr0)_C_Peptide (dog) Salt _ Binding _ Synonym SumFormula C146H234N38O51(Tyr0)_C_Peptide (dog) Salt _ Binding _ Synonym SumFormula C146H234N38O51([125I]-Tyr)-BNP-34 (3-34) (dog) Related articles to: Dog Tissue Frozen Sections Skin
- Pancreatic islets undergo coordinated cellular remodeling during obesity-induced insulin resistance. However, longitudinal changes across endocrine and non-endocrine compartments remain largely unexplored. We present a comprehensive high-resolution atlas using longitudinal single-cell RNA sequencing (scRNA-seq) and single-cell ATAC sequencing (scATAC-seq) on islets from C57BL/6 mice subjected to high-fat diet (HFD) feeding for 8, 16, and 24 weeks, along with age-matched controls on regular chow (RC). We mapped dynamic changes in islet cell composition and transcriptional states. Trajectory inference indicated diversification of beta-cell programs into adaptive and inflammatory states under HFD. Progression of insulin resistance induced shrinkage and transcriptional remodeling of glucagon-secreting alpha-cells, marked by upregulation of genes related to intracellular transport and oxidative stress, accompanied by the emergence of a polyhormonal alpha-cell subpopulation. Similarly, we identified delta-cell subpopulations exhibiting beta-like transcriptional signatures and polyhormonal identity under nutritional stress, suggesting adaptive delta-cell plasticity that may partially compensate for beta-cell loss during insulin resistance. The islet microenvironment exhibited robust expansion of proinflammatory M1 macrophages, reaching a plateau by 16 weeks of HFD, indicating niche saturation. Cell-cell communication analyses revealed disruption of key signaling pathways within endocrine and between endocrine and non-endocrine cells under HFD conditions. Notably, CCL27a-chemokine receptor signaling between beta-cells and M1 macrophages was significantly reduced in HFD islets, likely driven by reduced Ccl27a expression and chromatin accessibility in a distinct beta cell subpopulation, which we further validated using INS-1 cells exposed to HFD-like conditions. Comparative analysis with scRNA seq of human islets confirmed conserved stress signatures. Furthermore, genetic variants at the CCL27 locus were associated with increased T2D risk and HOMA-IR in human populations, establishing a novel link between beta-cell stress and systemic inflammation. This resource provides a hierarchical framework for understanding islet failure and identifies potential therapeutic nodes for type 2 diabetes. - Source: PubMed
Publication date: 2026/06/01
Singh SimranPavan Musale KrushnaBarella Luiz FTelang JayeshShree AjitaAgarwal ShrutiGoel AyushThaleshwari SaahibaWess JürgenZafar HamimPydi Sai Prasad - Vesicular cutaneous lupus erythematosus (VCLE) is a rare autoimmune disease in dogs and is considered the canine counterpart of human subacute cutaneous lupus erythematosus (SCLE). However, the molecular mechanisms underlying VCLE remain incompletely defined. - Source: PubMed
Publication date: 2026/05/11
Keating TreasaStranahan LaurenWiener DominiqueKeating M KellyLeon RenatoBanovic Frane - My research has focused on optimizing drug delivery system (DDS) related gene and cell therapies. In my gene therapy research, I first developed a polyethylene glycol (PEG)-conjugated adenovirus vector (PEG-Ad) to allow modulation of adenovirus pharmacokinetics and achieve tumor targeting. Evaluating correlations between PEG-Ad blood retention, tumor tissue delivery, liver accumulation, and gene expression is an important step toward creating tumor-targeting PEG-Ad, demonstrating that a 90% PEGylation rate optimally reduced liver accumulation and improved tumor targeting via enhanced permeability and retention. To enhance tumor targeting specificity, we designed Cys-Gly-Lys-Arg-Lys (CGKRK)-PEG-Ad, in which the tumor-targeting peptide CGKRK was attached to the end of the PEG chain. Although CGKRK-PEG-Ad exhibited similarly reduced liver accumulation to that of PEG-Ad, its tumor delivery was higher than that of PEG-Ad, demonstrating its potent therapeutic efficacy against metastatic tumors. Next, I worked to optimize tumor immunotherapy by controlling immune cells in vivo dynamics. In this study, cytokines were used to activate antitumor immune cells, and chemokines were used to induce intratumoral infiltration by antitumor immune cells. While intratumoral administration of Arg-Gly-Asp (RGD)-Ad-C-C motif chemokine ligand 27 (CCL27) alone did not produce an antitumor effect against OV-HM tumors; however, co-administration with RGD-Ad-interleukin-12 (IL-12) demonstrated a stronger antitumor effect than administration of RGD-Ad-IL-12 alone. Infiltration of cluster of differentiation 3 (CD3)- and perforin-positive cells into tumor tissues was increased by combined administration of RGD-Ad-CCL27 and RGD-Ad-IL-12 compared with administration of RGD-Ad-IL-12 alone. These results demonstrate the importance of controlling the in vivo dynamics of antitumor immune cells. - Source: PubMed
Nakagawa Shinsaku - Osimertinib is a primary treatment for patients with EGFR-mutated non-small cell lung cancer. But a significant number of patients receiving Osimertinib treatment suffer from cutaneous toxicity, which includes symptoms such as rash, itching, and hair loss. This study aims to help clinical patients suffering from cutaneous toxicity to improve their quality of life. Mice treated with 50 mg/kg/day Osimertinib for 42 days exhibited different levels of cutaneous toxicity. PI/Annexin-V apoptosis assay and western blotting were used to assess keratinocyte apoptosis and DNA damage. Osimertinib upregulated inflammatory factors including CCL2, CCL27, and IL18. Glycyrrhizic acid (GA) is the most important active ingredient in licorice with pharmacological effects such as anti-inflammatory, antiviral, and anti-apoptotic. Due to its rich bioactivity, the research about GA has always been popular. However, the effects of it on relieving cutaneous toxicity have not been studied yet. We have explored the therapeutic effects and mechanisms of GA on keratinocytes and C57BL/6 mice. Thirty milligrams/kg/day of GA could effectively reduce the frequency and severity of cutaneous toxicity induced by Osimertinib, restore epidermal thickness in mice, reduce DNA damage, and lower the expression levels of inflammatory factors. Our results indicated that GA could potentially mitigate the cutaneous toxicity caused by Osimertinib, which could position it as a promising adjunct in clinical practice. - Source: PubMed
Publication date: 2026/04/01
Wang CongyingLu JiabinFu HuangxiFeng XuejingXu ZhifeiLuo PeihuaYang BoHe QiaojunYang Xiaochun - Psoriasis is a refractory immune-related disease. In recent years, it has been discovered that mesenchymal stem cells (MSCs) can be used as a new therapeutic approach for psoriasis, but their potential therapeutic mechanism remains unclear. This study aims to explore the role of MSCs in the treatment of psoriasis. - Source: PubMed
Publication date: 2026/03/28
Lin QingJi YunfeiYang BinZhu RongjiaSong PingZhao Robert Chunhua