Dog Tissue cDNA, Adult Tissues Skin
- Known as:
- Dog Tissue complementary Desoxyribonucleic acid, Adult Tissues Skin
- Catalog number:
- DD-101
- Product Quantity:
- 30 reactions
- Category:
- -
- Supplier:
- Zyagen
- Gene target:
- Dog Tissue cDNA Adult Tissues Skin
Related genes to: Dog Tissue cDNA, Adult Tissues Skin
- Gene:
- CCL27 NIH gene
- Name:
- C-C motif chemokine ligand 27
- Previous symbol:
- SCYA27
- Synonyms:
- ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-30
- Date modifiied:
- 2016-10-05
Related products to: Dog Tissue cDNA, Adult Tissues Skin
(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat)
(Ser140)-Lipophilin (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat), (Ser140)-PLP (139-151(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated) (human, bovine, dog, mouse, rat) Salt Trifluoroacetate Binding _ Synonym (Ser140)_Lipophilin (139_151) (depalmitoylated) (human, bovi(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated) (human, bovine, dog, mouse, rat) Salt Trifluoroacetate Binding _ Synonym (Ser140)_Lipophilin (139_151) (depalmitoylated) (human, bovi(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated) (human, bovine, dog, mouse, rat) Salt Trifluoroacetate Binding _ Synonym (Ser140)_Lipophilin (139_151) (depalmitoylated) (human, bovi(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated) (human, bovine, dog, mouse, rat) Salt Trifluoroacetate Binding _ Synonym (Ser140)_Lipophilin (139_151) (depalmitoylated) (human, bovi(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated), human, bovine, dog, mouse, rat(Ser140)_Myelin Proteolipid Protein (139_151) (depalmitoylated), human, bovine, dog, mouse, rat(Tyr0)-C-Peptide (dog) 98% C146H234N38O51 CAS: 101135-67-5(Tyr0)_C_Peptide (dog) Salt _ Binding _ Synonym SumFormula C146H234N38O51(Tyr0)_C_Peptide (dog) Salt _ Binding _ Synonym SumFormula C146H234N38O51([125I]-Tyr)-BNP-34 (3-34) (dog) Related articles to: Dog Tissue cDNA, Adult Tissues Skin
- Vesicular cutaneous lupus erythematosus (VCLE) is a rare autoimmune disease in dogs and is considered the canine counterpart of human subacute cutaneous lupus erythematosus (SCLE). However, the molecular mechanisms underlying VCLE remain incompletely defined. - Source: PubMed
Publication date: 2026/05/11
Keating TreasaStranahan LaurenWiener DominiqueKeating M KellyLeon RenatoBanovic Frane - My research has focused on optimizing drug delivery system (DDS) related gene and cell therapies. In my gene therapy research, I first developed a polyethylene glycol (PEG)-conjugated adenovirus vector (PEG-Ad) to allow modulation of adenovirus pharmacokinetics and achieve tumor targeting. Evaluating correlations between PEG-Ad blood retention, tumor tissue delivery, liver accumulation, and gene expression is an important step toward creating tumor-targeting PEG-Ad, demonstrating that a 90% PEGylation rate optimally reduced liver accumulation and improved tumor targeting via enhanced permeability and retention. To enhance tumor targeting specificity, we designed Cys-Gly-Lys-Arg-Lys (CGKRK)-PEG-Ad, in which the tumor-targeting peptide CGKRK was attached to the end of the PEG chain. Although CGKRK-PEG-Ad exhibited similarly reduced liver accumulation to that of PEG-Ad, its tumor delivery was higher than that of PEG-Ad, demonstrating its potent therapeutic efficacy against metastatic tumors. Next, I worked to optimize tumor immunotherapy by controlling immune cells in vivo dynamics. In this study, cytokines were used to activate antitumor immune cells, and chemokines were used to induce intratumoral infiltration by antitumor immune cells. While intratumoral administration of Arg-Gly-Asp (RGD)-Ad-C-C motif chemokine ligand 27 (CCL27) alone did not produce an antitumor effect against OV-HM tumors; however, co-administration with RGD-Ad-interleukin-12 (IL-12) demonstrated a stronger antitumor effect than administration of RGD-Ad-IL-12 alone. Infiltration of cluster of differentiation 3 (CD3)- and perforin-positive cells into tumor tissues was increased by combined administration of RGD-Ad-CCL27 and RGD-Ad-IL-12 compared with administration of RGD-Ad-IL-12 alone. These results demonstrate the importance of controlling the in vivo dynamics of antitumor immune cells. - Source: PubMed
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