Chicken Acetylcholinesterase ELISA , AChE
- Known as:
- Chicken Acetylcholinesterase Enzyme-linked immunosorbent assay test , AChE
- Catalog number:
- E12A0712
- Category:
- -
- Supplier:
- Blue Gene Biotech
- Gene target:
- Chicken Acetylcholinesterase ELISA AChE
Related genes to: Chicken Acetylcholinesterase ELISA , AChE
- Gene:
- ACHE NIH gene
- Name:
- acetylcholinesterase (Cartwright blood group)
- Previous symbol:
- YT
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-02
- Date modifiied:
- 2019-04-23
Related products to: Chicken Acetylcholinesterase ELISA , AChE
Related articles to: Chicken Acetylcholinesterase ELISA , AChE
- Advancements in breast reconstruction, including prepectoral implant-based breast reconstruction, are increasingly being incorporated into same-day discharge protocols within enhanced recovery after surgery pathways. However, data evaluating patient-centered outcomes within these care models remain limited. This exploratory mixed methods study assessed satisfaction, safety perceptions, and implementation considerations among women undergoing same-day discharge after post-mastectomy prepectoral implant-based breast reconstruction post-COVID. Twenty participants completed semi-structured interviews with quantitative data from the Surgical Satisfaction Questionnaire and same-day discharge-specific items, and qualitative data that were subjected to content analysis. All participants reported satisfaction with postoperative pain control, and nearly all felt safe and satisfied with same-day discharge. Most were satisfied with return to daily and social activities, although fewer were satisfied with return to exercise. Qualitative findings identified factors supporting pathway success, including effective pain management and clear communication, as well as modifiable challenges related to preparation, early recovery vulnerability, and adjustment to longer-term changes. These findings highlight the patients' favorable views of same-day discharge and identify actionable targets to improve surgical care pathways, discharge protocols, and multidisciplinary follow-up in post-mastectomy pre-pectoral implant-based breast reconstruction. - Source: PubMed
Publication date: 2026/05/13
Pflueger Kiersten NMoyer AnnePatel DevikaScott Stacey BMunn BrittniBakoulis AnastasiaHuston Tara L - Multiple sclerosis (MS) is a chronic neuroinflammatory disorder, and approximately 50% of MS patients develop depression, making it one of the most common comorbidities of the disease. MS-related depression significantly reduces quality of life, worsens neurological disability, and increases suicide risk. Despite its high prevalence, the underlying mechanisms remain unclear. While neuroinflammation and neurotransmitter dysregulation have been implicated, recent evidence suggests that ferroptosis, an iron-dependent form of cell death, may contribute to both neuronal death and mood disturbances in MS patients. Ferroptosis is driven by iron accumulation, lipid peroxidation (LPO), and oxidative stress, all of which are elevated in MS lesions. The inflammatory environment in MS may exacerbate ferroptosis-related processes, potentially contributing to demyelination, neuronal dysfunction, and altered neurotransmitter metabolism-factors strongly linked to depressive symptoms. This review examines the potential role of ferroptosis in MS progression and MS-related depressive symptoms, with a particular focus on oxidative damage and inflammatory signaling related to iron metabolism in the central nervous system (CNS). Understanding these mechanisms may inform future therapeutic hypotheses for MS patients suffering from depression. - Source: PubMed
Publication date: 2026/05/26
Cao BingyueTan YujiaLiu PanPei Lijian - Organophosphorus nerve agents exert their acute toxicity by irreversibly inhibiting acetylcholinesterase (AChE), yet currently deployed oxime reactivators exhibit limited efficacy in the central nervous system due to poor blood-brain barrier (BBB) penetration. Addressing this limitation remains a critical challenge in the treatment of nerve agent exposure. We report the design, synthesis, and evaluation of JDS364, an uncharged hybrid oxime reactivator combining a quinoline-based peripheral site ligand with a 3-hydroxypyridinealdoxime nucleophile. In vitro studies using human AChE inhibited by surrogates of G- and V-series nerve agents demonstrated that JDS364 possesses broad-spectrum reactivation activity, notably achieving a 300-fold increase in reactivation efficiency (k) over the clinical benchmark obidoxime against tabun-like inhibited hAChE. Evaluation in a human in vitro BBB co-culture model revealed that JDS364 exhibits high permeability, significantly outperforming clinically used quaternary oximes and exceeding the flux of earlier-generation uncharged hybrids. Ex vivo functional profiling studies in mice confirmed rapid systemic availability and significant protection against paraoxon challenge (Protective Index = 6.7 when combined with atropine), though a narrower therapeutic window was observed compared to clinical standards. X-ray crystallographic analysis of JDS364 bound to human AChE uncovered ligand-induced conformational plasticity, providing the first structural evidence of an opening of a "backdoor" via Tyr449 rearrangement in the 20 Å deep active site gorge. This confirms the hypothesis of enzyme "breathing" motions and validates alternative diffusion pathways for reactivation. These findings establish JDS364 as a mechanistically significant, CNS-accessible lead that defines a new structural paradigm for the development of next-generation countermeasures. - Source: PubMed
Publication date: 2026/06/01
De Sousa JulienCalas André-GuilhemDe La Mora EugenioLandry ChristopheHanak Anne-SophieMaryan-Instone AlexGastellier Anne-JulieCoisne CarolineCourageux CharlotteHachani JohanGosselet FabienDehouck Marie-PierreRousseau CatherineTimperley Christopher MWeik MartinNachon FlorianBrown Richard C DBaati RachidDias José - Antibiotic resistance is a challenge in contemporary world. Urethroplasty for hypospadias is one of the most common urological surgeries performed around the world, yet, there is still no consensus on the use of antibiotics pre- and post-operatively. Our objective was to analyze the effectiveness of antibiotic prophylaxis and therapy before, during, and after hypospadias repair in children. - Source: PubMed
Publication date: 2026/05/20
Manasherova DinaKozyrev GermanKasyan GeorgePushkar Dmitry Y - Leiomyomas remain highly prevalent by midlife, with persistent racial disparities in age at onset and tumor burden. Although they are traditionally expected to regress after menopause, longitudinal data demonstrate variable behavior, with many leiomyomas persisting, some regressing modestly, and a subset continuing to grow. This structured, nonsystematic review of the contemporary literature was conducted using PubMed and Embase, supplemented by guideline and reference review, with the objective of guiding the evaluation and management of uterine leiomyomas across the menopausal transition. In perimenopausal and postmenopausal patients, abnormal uterine bleeding and pelvic pain require systematic evaluation to exclude endometrial pathology and alternative causes. Transvaginal ultrasonography with structured assessment provides the foundation for evaluation, and magnetic resonance imaging serves as an adjunct when findings are indeterminate or clinical concern is elevated. No single imaging feature reliably distinguishes benign leiomyoma from leiomyosarcoma, and the prevalence of unsuspected leiomyosarcoma at surgery remains low, increasing with age. Management should be individualized and symptom driven, incorporating patient age, comorbidities, hormonal exposures, imaging findings, and preferences, with expectant management appropriate for asymptomatic patients and intervention reserved for refractory symptoms or diagnostic uncertainty. - Source: PubMed
Publication date: 2026/06/04
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