Mouse polyclonal to UNC5D, Host Mouse
- Known as:
- Mouse pab UNC5D, Host Mouse
- Catalog number:
- YF-PA26889
- Product Quantity:
- 50 uL
- Category:
- -
- Supplier:
- Abfron
- Gene target:
- Mouse polyclonal UNC5D Host
Related genes to: Mouse polyclonal to UNC5D, Host Mouse
- Gene:
- UNC5D NIH gene
- Name:
- unc-5 netrin receptor D
- Previous symbol:
- -
- Synonyms:
- KIAA1777, Unc5h4
- Chromosome:
- 8p12
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-13
- Date modifiied:
- 2016-12-16
Related products to: Mouse polyclonal to UNC5D, Host Mouse
Related articles to: Mouse polyclonal to UNC5D, Host Mouse
- Post-traumatic stress disorder (PTSD) involves hippocampal and prefrontal dysfunction. Cannabidiol (CBD) shows therapeutic promise, but its cell-type-specific and causal mechanisms remain unclear. - Source: PubMed
Publication date: 2026/07/28
Rao HuiXie GuanboWu NingLi JinHan Xiao - Metastasis remains the primary cause of breast cancer mortality. Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype. It lacks targeted therapies and carries a high risk of metastasis. MiRNAs are one of the potential diagnostics and therapeutic biomarkers, given that the regulation of mRNA is critical for tumor growth and metastatic transformation of tumor cells. Identifying the differential expression of the miRNA-mRNA axis at the primary tumor site will provide novel molecular mechanisms for metastasis initiation. In this study, we applied an integrated approach to explore the metastasis-specific miRNA-mRNA regulatory axis in TNBC using TCGA-derived miRNA-seq and RNA-seq data. Differential expression analysis between metastatic and non-metastatic TNBC patient data identified 11 dysregulated miRNAs, of which 8 showed linear expression changes with increasing disease aggressiveness. Among them, hsa-miR-1-1/2, hsa-miR-9, and hsa-miR-1180 displayed strong diagnostic potential (AUC >0.8) and significant associations with overall survival in metastatic TNBC patients. Parallel RNA-seq analysis revealed 36 differentially expressed genes (DEGs). Target prediction highlighted that only hsa-miR-9-5p targeted three of the 36 DEGs-FABP7, GPR26, and UNC5D, where FABP7 demonstrated strong association with cancer pathways. The expression of these genes was also correlated with the overall survival of the TNBC patients. Validation of this axis in various breast cancer cells (metastatic and non-metastatic) was performed, and the results indicated an inverse expression pattern of hsa-miR-9-5p and FABP7, especially in metastatic TNBC cells. These findings propose the hsa-miR-9-FABP7 axis as a promising biomarker signature for predicting metastatic potential from primary TNBC tumors. - Source: PubMed
Publication date: 2026/07/24
Rathore DeepshikhaDheer VasundharaSingh SurbhiPatel ShanayaDesai ChiragDave Heena V - Oral Submucous Fibrosis (OSMF) is a significant global oral health problem, particularly prevalent in India, with a high risk of progression to Oral Squamous Cell Carcinoma (OSCC). This study investigates the molecular mechanisms involved in the transformation of OSMF to OSCC using transcriptomic profiling. High-throughput RNA sequencing was performed on fresh de novo OSCC samples ( = 8) and OSMF derived OSCC using Illumina-compatible NEXTflex Rapid Directional RNA Sequencing. Normalization and differential gene expression analysis were conducted, and genes exhibiting an absolute log2 fold change of ≥2 with a co-variate-adjusted -value ≤ 0.05 were identified as significant. Upregulated genes were associated with cytokine and immune responses (ABRA, TTTY14, EIF1AY), cellular proliferation and apoptosis (LINC00314, RPS4Y1, SERPINA5, TRIM63, FABP7), and energy metabolism, indicating metabolic adaptations during malignant progression. Pathway analysis showed increased expression of TNNT1, TNNI1, MYL4, and ACTN3, implicating muscle development and embryonic pathways in OSMF transformation. Conversely, genes related to epithelial differentiation and keratinization (FLG, FLG2, HRNR, TCHH, KRT73), immune regulation and tumor suppression (HLA-G, UNC5D), and metabolic signaling were downregulated, reflecting loss of tissue integrity and immune control. OSMF-derived OSCC exhibits a distinct transcriptomic landscape compared with de novo OSCC, characterized by altered epithelial differentiation, immune modulation, and activation of developmental pathways. The observed gene dysregulation findings establish that OSCC developing in the background of OSMF is molecularly distinct from de novo OSCC, underscoring the biological impact of the pre-existing fibrotic milieu on tumor transcriptional architecture. - Source: PubMed
Publication date: 2026/03/10
Prasad KavithaSamudrala Venkatesiah SowmyaAugustine DominicAnand Ananya AnuragKaryala PrashanthiDasharathy SukeerthiRao Roopa SChaki Soma - The large yellow croaker () is a key mariculture species in China, however, its industry is threatened by visceral white nodules disease (VWND) caused by the bacterium . A significant challenge in breeding is the potential genetic trade-off between growth and disease resistance. To investigate their genetic relationship, we constructed a high-density SNP-based genetic linkage map for using a F1 full-sib family ( = 150). The map comprised 24 linkage groups with 32,429 bin markers and an average interval of 0.051 cM. Based on this map, we conducted QTL mapping for one yield trait (body weight), eight morphological traits, and three VWND-resistance traits (survival time, AT; spleen and liver pathogen loads). Phenotypic analysis revealed strong integration among growth traits and a moderate positive correlation between growth traits and AT. QTL mapping identified 53 QTLs for growth (PVE = 0.14-5.83%) and 20 for resistance (PVE = 0.78-8.93%). Notably, only two genomic intervals exhibited co-localization between a morphological trait (AL or BL) and AT, each explaining a modest phenotypic variance (0.66-5.99%). The largest-effect QTLs for growth and resistance were mapped to distinct linkage groups, and candidate genes within the co-localized intervals (, , ) are involved in fundamental cellular processes rather than core growth or immune pathways. These results suggest that yield, morphological, and VWND-resistance traits in are largely under independent genetic control within the studied family, indicating that simultaneous improvement of growth and disease resistance is feasible. This study provides a molecular basis for breeding strategies aimed at overcoming the trait trade-off bottleneck in this economically vital species. - Source: PubMed
Publication date: 2026/03/10
Ye TingGuo DandanZhou YilianLou BaoLiu Feng - Basement membrane-related genes (BMRGs) play a crucial function in the progression of various malignancies. This study aimed to explore the relationship between BMRGs and colon cancer. - Source: PubMed
Publication date: 2025/11/19
Wei JiajieWang HouZeChai JianGuo CeGong TianYiWang HengLi XiaoLongWu HaiFengXing BaoJianZhang YaJuanZhang HuiQingGuo Xing