Mouse polyclonal to CPNE4, Host Mouse
- Known as:
- Mouse pab CPNE4, Host Mouse
- Catalog number:
- YF-PA26873
- Product Quantity:
- 50 uL
- Category:
- -
- Supplier:
- Abfron
- Gene target:
- Mouse polyclonal CPNE4 Host
Related genes to: Mouse polyclonal to CPNE4, Host Mouse
- Gene:
- CPNE4 NIH gene
- Name:
- copine 4
- Previous symbol:
- -
- Synonyms:
- COPN4, CPN4
- Chromosome:
- 3q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-09
- Date modifiied:
- 2016-01-26
Related products to: Mouse polyclonal to CPNE4, Host Mouse
Related articles to: Mouse polyclonal to CPNE4, Host Mouse
- Liangshan Meigu Yanying chicken is an indigenous high-altitude breed in Sichuan, China, but its population genetic structure and the genetic basis of key growth and meat-quality traits remain unclear. In this study, 211 Meigu Yanying chickens were whole-genome resequenced, and leg muscle weight, liver weight, leg muscle total protein content and leg muscle total cholesterol content were recorded at slaughter. After quality control, high-confidence single-nucleotide polymorphisms were used to analyze linkage disequilibrium, population structure and genome-wide associations. Linkage disequilibrium decayed rapidly with distance, and multivariate analyses indicated an overall homogeneous genetic background with only mild substructure and few closely related individuals. Genome-wide association studies for the four traits detected several significant or suggestive regions harboring biologically plausible candidate genes, including CPNE4, PLXNB2, SMAP1, SDHAF4, FAM135A, LCP1, MAPK15 and SCRIB. Gene Ontology enrichment showed that candidate genes for leg muscle weight and liver weight were mainly involved in cellular processes and tissue development, whereas those for leg muscle total cholesterol content were enriched in phosphorus metabolism and phosphate-containing compound metabolism. These results provide a genome-wide resource for Meigu Yanying chickens and lay a basis for conservation and genomic breeding aimed at improved growth performance, meat quality and nutritional value. - Source: PubMed
Publication date: 2026/02/09
Hu YaodongCai BinjianLi TianyuTang ShiWang SiluSun CaiyunChen BinlongRen Peng - Diagnosing leukemia often depends on invasive bone marrow biopsies, which can be painful and may fail to detect the early stages of the disease. Liquid biopsy, a minimally invasive method that analyzes circulating biomarkers in blood, has emerged as a powerful tool for the early detection of leukemia. Among emerging technologies, liquid chromatography-tandem mass spectrometry (LC-MS/MS) enables high-throughput and sensitive profiling of blood-based proteins, thereby creating new opportunities for biomarker discovery. This mini-review highlights the clinical potential of LC-MS/MS in liquid biopsy for leukemia, with a focus on T-cell acute lymphoblastic leukemia (T-ALL). Recent proteomic studies have identified distinct protein signatures in the blood of T-ALL patients, such as XRRA1, CPNE4, and S100A8, which show substantial diagnostic value. We also address similar applications in acute myeloid leukemia (AML), the challenges of clinical translation, and the future integration of proteomics with multi-omics diagnostic platforms. Importantly, we discuss the limitations of current studies (e.g., small cohorts, limited diversity, and reproducibility issues) and the path toward clinical implementation, including validation in larger trials, regulatory considerations, cost-effectiveness, and the need for standardized protocols. LC-MS/MS-driven liquid biopsy represents a promising advancement toward earlier, less invasive, and more precise leukemia diagnostics, provided that robust validation and harmonization efforts are successful. - Source: PubMed
Publication date: 2025/08/08
Singh Vivek - Age-related hearing loss (ARHL) is one of the most prevalent conditions affecting the elderly. ARHL is influenced by a combination of environmental and genetic factors; the identification of the genes that confer risk will aid in the prevention and treatment of ARHL. The mouse and human inner ears are functionally and genetically homologous. We used Carworth Farms White (CFW) mice to study the genetic basis of ARHL because they are genetically diverse and exhibit variability in the age of onset and severity of ARHL. - Source: PubMed
Publication date: 2025/05/21
Polesskaya OksanaBoussaty ElyCheng RiyanLamonte Olivia AZhou Thomas YDu EricSanches Thiago MissfeldtNguyen Khai-MinhOkamoto MikaPalmer Abraham AFriedman Rick - Runs of homozygosity (ROH) are continuous segments of homozygous genotypes inherited from both parental lineages. These segments arise due to the transmission of identical haplotypes. The genome-wide patterns and hotspot regions of ROH provide valuable insights into genetic diversity, demographic history, and selection trends. In this study, we analyzed whole-genome resequencing data from 117 rabbits to identify ROH patterns and inbreeding level across eleven rabbit breeds, including seven Chinese indigenous breeds and four exotic breeds, and to uncover selective signatures based on ROH islands. - Source: PubMed
Publication date: 2025/04/29
Ping XinxinChen YuanWang HuiJin ZhuoyaDuan QiantingRen ZhanjunDong Xianggui - Age-related hearing impairment is the most common cause of hearing loss and is one of the most prevalent conditions affecting the elderly globally. It is influenced by a combination of environmental and genetic factors. The mouse and human inner ears are functionally and genetically homologous. Investigating the genetic basis of age-related hearing loss (ARHL) in an outbred mouse model may lead to a better understanding of the molecular mechanisms of this condition. We used Carworth Farms White (CFW) outbred mice, because they are genetically diverse and exhibit variation in the onset and severity of ARHL. The goal of this study was to identify genetic loci involved in regulating ARHL. Hearing at a range of frequencies was measured using Auditory Brainstem Response (ABR) thresholds in 946 male and female CFW mice at the age of 1, 6, and 10 months. We obtained genotypes at 4.18 million single nucleotide polymorphisms (SNP) using low-coverage (mean coverage 0.27x) whole-genome sequencing followed by imputation using STITCH. To determine the accuracy of the genotypes we sequenced 8 samples at >30x coverage and used calls from those samples to estimate the discordance rate, which was 0.45%. We performed genetic analysis for the ABR thresholds for each frequency at each age, and for the time of onset of deafness for each frequency. The SNP heritability ranged from 0 to 42% for different traits. Genome-wide association analysis identified several regions associated with ARHL that contained potential candidate genes, including , and . We confirmed, using functional study, that Prkag2 deficiency causes age-related hearing loss at high frequency in mice; this makes a candidate gene for further studies. This work helps to identify genetic risk factors for ARHL and to define novel therapeutic targets for the treatment and prevention of ARHL. - Source: PubMed
Publication date: 2024/06/10
Polesskaya OksanaBoussaty ElyCheng RiyanLamonte OliviaZhou ThomasDu EricSanches Thiago MissfeldtNguyen Khai-MinhOkamoto MikaPalmer Abraham AFriedman Rick