Mouse polyclonal to COL23A1, Host Mouse
- Known as:
- Mouse pab COL23A1, Host Mouse
- Catalog number:
- YF-PA26778
- Product Quantity:
- 50 uL
- Category:
- -
- Supplier:
- Abfron
- Gene target:
- Mouse polyclonal COL23A1 Host
Related genes to: Mouse polyclonal to COL23A1, Host Mouse
- Gene:
- COL23A1 NIH gene
- Name:
- collagen type XXIII alpha 1 chain
- Previous symbol:
- -
- Synonyms:
- DKFZp434K0621
- Chromosome:
- 5q35.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-12
- Date modifiied:
- 2016-05-26
Related products to: Mouse polyclonal to COL23A1, Host Mouse
Related articles to: Mouse polyclonal to COL23A1, Host Mouse
- Thyroid cancer, the most prevalent endocrine malignancy globally, poses challenges owing to the limited understanding of its molecular drivers. Previous research has highlighted collagen genes, such as COL13A1 and COL23A1, as key players in thyroid cancer. This study aimed to comprehensively investigate gene expression, genetic alterations, DNA methylation, and the prognostic significance of COL13A1 and COL23A1. - Source: PubMed
Publication date: 2026/06/15
Islam Md WahidulRahman Md MinhajurNaznin HomairaHossain Md ShohelAkter TahminaShatabde Zayeda AkterHossain Md Jubayer - PURPOSE: In this study, we investigated the effect of ELF5, KIF18A, NPTX1 and COL23A1 genes in residual processus vaginalis (PV) the main factor in the development of indirect inguinal hernia (IIH) in children. METHODS: Cases operated for IIH in children aged 0–18 years between 2018 and 2021 constituted the study group, and cases with undescended testis without hernia the control group. Protein levels of KIF18A, which has the highest gene expression in tissue samples, were also analyzed by ELISA method. Polymorphisms of ELF5, KIF18A and COL23A1 genes with the highest level of expression change in blood and tissue samples were analyzed by qRT-PCR. Statistical analysis was performed. RESULTS: There were 186 patients in the study group and 26 patients in the control group. The results of ELF5, KIF18A and COL23A1 genes were significantly higher in the study group than in the control group. There was a statistically significant positive correlation between GAPDH and ELF5, KIF18A and NPTX1 in the study group. Also, a statistically significant positive correlation was found between KIF18A and ELF5 and between NPTX1 and ELF5 and COL23A1. CONCLUSION: The present study may be the first study conducted in human tissue samples that we could access in the literature in terms of the genetic factors. It was predicted that ELF5, KIF18A and COL23A1 genes may be counted among the effective factors in PV closure. This study may shed light on larger prospective genetic studies. - Source: PubMed
Publication date: 2026/04/02
Genc ErcanTartar TugayOnalan EbruBakal UnalSarac MehmetKaymaz TugceKazez Ahmet - Selective serotonin reuptake inhibitors (SSRIs) are a recommended first line medication for the treatment of major depressive disorder, due to higher tolerability and lower risk of adverse effects than other antidepressants. The mechanisms by which SSRIs reduce depressive symptoms are not well understood, but are hypothesised to include direct effects on serotonin signalling and synaptic remodelling, and indirect effects on inflammation. Indirect or off-target effects may be detectable in blood and can be investigated using methylome- and transcriptome-wide approaches. - Source: PubMed
Publication date: 2026/02/25
Barker Lauren FMcRae Allan FYuen Hok PanHenders Anjali KWallace Leanne MLin TianDavyson EllaPhassouliotis ChristinaSpark JessicaKerr MelissaStreet RebekahByrne Enda MAmminger G PaulNelson BarnabyWray Naomi RMcGorry Patrick D - Endometrial cancer (EC) is one of the most common gynecological malignancies, and its progression is tightly linked to extracellular matrix (ECM) remodeling and metabolic reprogramming. Collagen type XXIII alpha 1 (COL23A1), a transmembrane collagen, has been implicated in several cancers, but its expression pattern, functional role and upstream regulation in EC remain unclear. Public datasets (TCGA, GTEx, cBioPortal) were analyzed to characterize COL23A1 expression, clinicopathological correlations and prognostic value. The biological functions of COL23A1 in EC cells were assessed by qRT-PCR, Western blotting, CCK-8, colony formation, flow cytometry, Transwell assays and Seahorse extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) measurements. Untargeted metabolomics and RNA immunoprecipitation (RIP) were used to interrogate glycolytic metabolism and m⁶A modification. Xenograft models were established to validate the in vivo effects of COL23A1. COL23A1 was significantly upregulated in EC tissues and correlated with advanced clinicopathological features and poor overall survival. Genetic silencing of COL23A1 suppressed EC cell proliferation, clonogenicity, migration and invasion in vitro, and inhibited tumor growth in vivo. At the metabolic level, COL23A1 knockdown disrupted glycolytic metabolism, leading to reduced glucose uptake, lactate production, expression of key glycolytic enzymes and ECAR, accompanied by a compensatory increase in OCR. Integrative bioinformatic and experimental analyses showed that METTL14 installs m⁶A modifications on COL23A1 mRNA, whereas the m⁶A reader YTHDF1 binds and stabilizes the modified transcript, thereby sustaining COL23A1 expression. Rescue experiments demonstrated that COL23A1 is required for METTL14- and YTHDF1-driven glycolytic reprogramming and oncogenic phenotypes in EC cells. COL23A1 acts as a previously unrecognized oncogenic driver in endometrial cancer, promoting tumor progression and glycolysis-dependent metabolic reprogramming through a METTL14-m⁶A-YTHDF1-COL23A1 axis. Targeting this m⁶A-dependent pathway may offer a promising therapeutic strategy for endometrial cancer. - Source: PubMed
Publication date: 2026/01/27
Wu HuazhenKe MiaoFeng XiaoliLi ZehanLuo YuanweiBian FanghuiLiao JiaTang Ruiming - Improvement of protein efficiency (PE) is a key factor for a sustainable pig production, as nitrogen excretion contributes substantially to environmental pollution. Protein efficiency has been shown to be heritable and genetically correlated with performance traits such as feed conversion ratio (FCR) and average daily feed intake (ADFI). This study aimed to identify genomic regions associated with these traits through single-variant genome-wide association studies (GWAS) and regional heritability mapping (RHM) using whole-genome sequence variants from low-pass sequencing of more than 1000 Swiss Large White pigs. - Source: PubMed
Publication date: 2025/08/14
Ewaoluwagbemiga Esther OluwadaLloret-Villas AudaldNosková AdélaPausch HubertKasper Claudia