Mouse polyclonal to RHOT2, Host Mouse
- Known as:
- Mouse pab RHOT2, Host Mouse
- Catalog number:
- YF-PA26772
- Product Quantity:
- 50 uL
- Category:
- -
- Supplier:
- Abfron
- Gene target:
- Mouse polyclonal RHOT2 Host
Related genes to: Mouse polyclonal to RHOT2, Host Mouse
- Gene:
- RHOT2 NIH gene
- Name:
- ras homolog family member T2
- Previous symbol:
- C16orf39, ARHT2
- Synonyms:
- MIRO-2
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-07-10
- Date modifiied:
- 2015-09-07
Related products to: Mouse polyclonal to RHOT2, Host Mouse
Related articles to: Mouse polyclonal to RHOT2, Host Mouse
- Pregnancy-associated hemodynamic overload and hormonal changes induce hypertrophy and metabolic remodeling of the maternal heart. Mitochondrial motility, mediated by ras homolog family member T (RHOT) 1 and RHOT2, is essential for cardiac adaptation to increased workload, cardiomyocyte hypertrophy, and sarcomere maturation. To test the hypothesis that expression is required for pregnancy- and postpartum-associated adaptations of the maternal heart, female mice with tamoxifen-inducible, cardiomyocyte-selective deletion of and (iRhot1/2-KO) were mated. Following gene deletion in adult mice, cardiac tissue and function were analyzed after three to five successive pregnancies and postpartum nursing periods. Age-matched nulliparous iRhot1/2-KO mice and age-matched mice expressing and served as controls. Motility of mitochondria isolated from iRhot1/2-KO hearts was impaired, as determined by the number of mobile mitochondria in an in vitro motor protein-driven single mitochondrion motility assay performed on surface-immobilized microtubules. Despite loss of expression, contractile function assessed by transthoracic echocardiography, mRNA expression of peripartum-associated heart failure markers, cardiac structure, mitochondrial morphology, mitochondrial enzymatic activity, and mitochondrial DNA content were all comparable to controls expressing at the investigated time points. RNA sequencing-based gene profiling identified a transcriptional program through which RHOT proteins preserve cardiac energetic and contraction gene expression during pregnancy and postpartum. Together, cardiomyocyte-selective loss of expression in the adult heart does not cause peripartum-associated heart failure, despite reduced cardiac energetic and contraction gene expression. - Source: PubMed
Publication date: 2026/05/30
Froese NataliSina EluiesaGaluppo PaoloWerlein ChristopherGigina AnnaHegermann JanGeffers RobertScholz TimKamp Jan CNeubert LaviniaSchneider JohannaRicke-Hoch MelanieDietl AlexanderBauersachs JohannRiehle Christian - Myosin-19 (Myo19) plays a crucial role in mitochondrial dynamics, cristae organization and ER-mitochondria contact sites. It regulates cytokinesis and inheritance of mitochondria to daughter cells. To better understand the dynamic molecular network of Myo19 during the cell cycle, we determined the in vivo proximity protein interaction networks of Myo19 in interphase and prometaphase using proximity-based TurboID biotinylation followed by mass spectrometry. We further determined the proximity networks of its known mitochondrial binding partners Miro2 and metaxin-3. The outer mitochondrial membrane protein Miro2 not only binds but also stabilizes Myo19. This interaction depends on the nucleotide state of the N-terminal GTPase domain of Miro2. Therefore, we analysed both the proximity networks of Miro2 and its GTP-binding mutant Miro2 T18N. We were able to show a differential association of Myo19 during the cell cycle with functional protein clusters and a participation of Myo19 in mitochondrial trafficking, ER-mitochondria contact sites and mitochondria intermembrane space bridging complex/cristae organizing system. The proximity network of Myo19 showed more overlap with Miro2 than metaxin-3. Abolishing GTP-binding to the N-terminal GTPase domain of Miro2 reduced the number of proteins in proximity of Miro2 considerably. In conclusion, we discovered a comprehensive dynamic in vivo protein proximity network of Myo19 and its mitochondrial receptors Miro2 and metaxin-3. - Source: PubMed
Publication date: 2026/05/06
Attia AyaEirich JürgenHonnert UlrikeNikolaus PetraLohmann BirgitFinkemeier IrisBähler Martin - Pre-eclampsia (PE) is a specific type of gestational hypertension associated with high morbidity and mortality. This study aims to identify mitochondria-related regulatory molecules in PE through bioinformatics analysis, which will help pinpoint potential therapeutic targets and elucidate potential mechanisms of action in PE. - Source: PubMed
Publication date: 2026/03/24
Wang YaohuiDu ZhixinYang LipingHou JunlinLi XiaolinFan MengyangYu ChenyangSun JianhuaZhou LiLi LinglingFan Pengbei - Post-stroke depression (PSD), a prevalent neuropsychiatric complication of stroke, manifests as persistent low mood and depressive symptoms secondary to cerebrovascular injury, contributing to increased morbidity and mortality. Although the modified Jie-Yu-He-Huan (MJYHH) capsule has demonstrated clinical efficacy in alleviating PSD symptoms, its pharmacological targets and mechanisms of action remain unclear. - Source: PubMed
Publication date: 2026/02/04
Wang XinyuGao QianLiu ChaoHu MinghuiLiu ZhiyaoLi ZifaZhang HaoWu LidanChen KaiXu KaiyongGeng XiwenLiu WeiWei Sheng - Cardiomyocyte mitochondria align with sarcomeres during heart development. Mitochondrial motility is controlled by RHOT (ras homolog family member T) 1 and RHOT2. RHOT1 and RHOT2 are atypical Rho-like small GTPases that are anchored to the outer mitochondrial membrane and couple mitochondria to kinesin and dynein motors. We hypothesized that RHOT protein expression and mitochondrial motility are required for mitochondrial positioning during cardiomyocyte development. - Source: PubMed
Publication date: 2026/03/16
Froese NataliShymotiuk IvannaFroese AlexanderPolten FelixJablinski JonasScholz TimKorf-Klingebiel MortimerWerlein ChristopherGaluppo PaoloGigina AnnaWihler KatharinaSchneider JohannaErschow SergejHeimerl MarenSzaroszyk MalgorzataHegermann JanWrede ChristophSchweitzer TheresaPich AndreasGeffers RobertRicke-Hoch MelanieKühnel Mark PJonigk Danny DWende Adam RAbel E DaleNikolaev Viacheslav OWollert Kai CBauersachs JohannRiehle Christian