Mouse polyclonal to TSGA2, Host Mouse
- Known as:
- Mouse pab TSGA2, Host Mouse
- Catalog number:
- YF-PA26768
- Product Quantity:
- 50 uL
- Category:
- -
- Supplier:
- Abfron
- Gene target:
- Mouse polyclonal TSGA2 Host
Related genes to: Mouse polyclonal to TSGA2, Host Mouse
- Gene:
- RSPH1 NIH gene
- Name:
- radial spoke head component 1
- Previous symbol:
- TSGA2
- Synonyms:
- FLJ32753, RSP44, RSPH10A, CILD24
- Chromosome:
- 21q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-17
- Date modifiied:
- 2018-06-22
Related products to: Mouse polyclonal to TSGA2, Host Mouse
Related articles to: Mouse polyclonal to TSGA2, Host Mouse
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Publication date: 2026/06/29
Guo LianheChen XiangjinZhou Fan - Intermittent hypoxia (IH) is a hallmark pathological feature of obstructive sleep apnea and a critical risk factor for neurodegenerative diseases such as Alzheimer's disease. Transcription factors (TFs) and splicing factors (SFs) serve as pivotal regulators orchestrating cellular adaptations to hypoxia. This study aimed to elucidate the dynamic changes and identify candidate key TFs and SFs in the mouse hippocampus under IH. By establishing an IH mouse model (7% O, 1/3/5/7 weeks) and integrating multi-time points RNA-seq with bioinformatic analysis and experimental validation, we systematically identified putative core TFs and SFs involved in hippocampal hypoxia response and inferred their potential functions. Our study revealed that the TFs Lef1 and Foxj1, along with the SF Rbm47, emerge as candidate key regulators. Lef1 may modulate apoptosis-related genes such as Il31ra, while Foxj1 could be linked to ciliary function and neural development by regulating genes like Rsph1. The SF Rbm47 potentially contributes to hippocampal hypoxic adaptation by modulating alternative splicing of genes such as Apc and Hnrnpa2b1. The Lef1 gene itself undergoes alterations in exon retention rates during intermittent hypoxia. These findings provide critical data to decipher hippocampal IH adaptation and offer theoretical insights into the mechanisms of AD and related neurodegenerative disorders. - Source: PubMed
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Liu ChunchengLi XiaoyuPu WenhuaJing JingCui WenjiaLiu GuojunCai Lu - Primary ciliary dyskinesia (PCD) is a rare disease caused by mutations in >50 genes that impair the function of motile cilia. The clinical phenotype is heterogeneous and recent studies have begun to investigate genotype-phenotype relationships to better understand disease pathogenesis and develop improved treatments. The major cause of morbidity and mortality among individuals with PCD is the lack of mucociliary clearance (MCC) that results in chronic respiratory infections and leads to bronchiectasis. Here we examine the relationship between MCC and genotype in two groups of PCD individuals; one with mutations in a gene () that causes PCD with mostly immotile cilia and one with mutations in a gene () that cause PCD with cilia that beat with a near-normal frequency, but an abnormal, sometimes circular waveform. - Source: PubMed
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