Rabbit polyclonal to PITX2, Host Rabbit
- Known as:
- Rabbit pab PITX2, Host Rabbit
- Catalog number:
- YF-PA13799
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Abfron
- Gene target:
- Rabbit polyclonal PITX2 Host
Related genes to: Rabbit polyclonal to PITX2, Host Rabbit
- Gene:
- PITX2 NIH gene
- Name:
- paired like homeodomain 2
- Previous symbol:
- IRID2, IHG2, RIEG, RIEG1, RGS
- Synonyms:
- IGDS, RS, Brx1, Otlx2, ARP1
- Chromosome:
- 4q25
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-05
- Date modifiied:
- 2016-01-27
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- Crohn's disease (CD) is highly heterogeneous in presentation and progression with no cure. Molecular phenotyping has been used to elucidate cellular and tissue-based alterations to characterize drivers and effects of disease. One currently understudied class of functional molecules is long non-coding RNAs (lncRNAs). Studying the full lncRNA landscape in CD is challenging due in part to an incomplete lncRNA annotation and a lack of their functional characterization in tissues of interest. We used a genome-guided alignment strategy to assemble predicted lncRNA transcripts using short RNA-sequencing data from colon tissue of adult patient samples. When combining our predicted lncRNAs with previous lncRNA annotations, we determined 98 that were differentially expressed, recapitulating many from previous IBD studies while also uncovering new ones. We built gene co-expression networks to cluster lncRNAs with functionally characterized protein-coding genes. Clusters containing differential lncRNAs were correlated to disease status and associated with pathways related to the humoral immune response, metabolism, and tissue regeneration. We uncovered multiple differential lncRNAs whose expression significantly correlated with nearby differential protein-coding genes that have also been differentially expressed in other IBD datasets, such as PITX2. We focused on a predicted lncRNA that is antisense to the PITX2-adjacent lncRNA PANCR, which we called PANCR-AS1, and provide multiple lines of evidence that support PANCR-AS1 functioning as an enhancer of PITX2 expression. Overall, we determined lncRNAs that are potential contributors to CD pathogenesis. We developed a robust pipeline for identifying lncRNAs in diseased and non-diseased tissue that are absent from reference annotations. We also outlined a framework to pinpoint significant disease-associated lncRNAs with potential functional activity related to their nearby protein-coding genes. - Source: PubMed
Publication date: 2026/05/25
Kennedy Ng Meaghan MSilverstein SophieNishiyama Nina CBeasley CarolineLian GraceHuan BenjaminLau GwenWeaver DavidAwad AyeshSchaner Matthew RSheikh Shehzad ZFurey Terrence S - Post-stroke depression (PSD) affects approximately 30% of stroke survivors and worsens functional outcomes, yet its biological basis remains poorly understood. - Source: PubMed
Xu Zhi-JieZhang Su-XiangLi Ji-LingWu Jia-JiaMa JieMa Zhen-ZhenTao Ji-MingHua Xu-YunXu Jian-Guang - Topologically associating domains (TADs) are fundamental units of three-dimensional genome organization, and their boundaries play important roles in gene regulation and genomic stability. However, accurate computational prediction of TAD boundaries remains challenging because of the complex interplay between DNA sequence and epigenomic regulatory signals. Here we present CT-TADB, a hybrid CNN-Transformer framework that integrates DNA sequence with histone modification and CTCF binding signals to predict TAD boundaries without requiring Hi-C data. Trained on six human cell lines, CT-TADB achieved AUC values of 0.932-0.950, demonstrating competitive or superior performance relative to existing multi-modal methods. The model maintained stable performance on strictly independent and dataset-specific boundary subsets, and exhibited robust cross-cell-type transferability and cross-species generalization between human and mouse (AUC > 0.80 for human-to-mouse transfer). Feature attribution analysis identified CTCF as the dominant boundary-associated factor, supported by active chromatin marks, and quantitative attention analysis revealed significant long-range CTCF-mediated dependencies (p < 0.001). CT-TADB further identified a clinically validated PITX2-associated TAD boundary linked to cardiac arrhythmia and captured condition-specific boundary dynamics. By leveraging routinely available epigenomic data, CT-TADB provides a practical and complementary framework for investigating chromatin architecture across diverse biological contexts. - Source: PubMed
Publication date: 2026/05/09
Chen TongWang ShuaibinJin YuyuYuan YuanLiang ZhenShen Yin - Early-stage diagnosis of paroxysmal atrial fibrillation (PAF) is challenging owing to its asymptomatic nature. However, the genetic factors underlying PAF and predictive utility of polygenic risk scores (PRSs) for PAF in Asian populations remain elusive. We aimed to explore the PAF-associated genetic variants in a Japanese cohort and evaluate the predictive performance of PAF-specific PRSs. This study included 2,604 participants. Following exclusion, quality control, and genotype imputation, a genome-wide association study (GWAS) was conducted. The predictive performance of 30 sets of PRS models constructed across various thresholds was evaluated using three machine learning methods. Model performance was assessed using area under the curve (AUC) and SHapley Additive exPlanations (SHAP). The GWAS using 1,038 PAF cases and 744 controls identified 82 genome-wide significant variants (P < 5 × 10-8), all on chromosome 4q25. Of these, 80 variants clustered upstream of PITX2, and two were located in LINC01438. Fine mapping identified two independent intergenic signals, with rs2200732 as the lead single-nucleotide polymorphism. The best PRS-only model achieved an AUC of >0.70, which was improved up to 0.737 in additive models incorporating both PRS and clinical variables. SHAP analysis consistently ranked PRS as the most influential predictor among the clinical variables included in this study. These results suggest that genetic risk, particularly at the established 4q25/PITX2 locus, contributes substantially to PAF susceptibility in this Japanese cohort and that PRS may improve early risk stratification when integrated with clinical risk factors. - Source: PubMed
Publication date: 2026/05/04
Shiomi MegumiNagata YukiSudo TakeakiTakahashi KentaroHiguchi ChihiroIhara KensukeAsada KenTanaka YasuakiYamauchi YasuteruSasaki TakeshiHachiya HitoshiImai YasushiFujita HideoSasano TetsuoFurukawa TetsushiTanaka Toshihiro - ADAMTS1 (a disintegrin-like and metalloproteinase domain with thrombospondin type 1 repeats) is a secreted metalloproteinase with a known role in extracellular matrix remodeling in cardiovascular development and female fertility. Because of conflicting report of embryonic lethality and survival in mutant mice, we report generation and characterization of a new knockout (KO) allele, which led to detection of neonatal lethal omphalocele (persistent umbilical hernia) as a new -dependent birth defect. This phenotype was also detected in another mutants with an in-frame insertion. β-galactosidase staining in the latter showed that was strongly expressed in the undifferentiated cells in the developing ventral abdominal wall preceding midline fusion at the umbilical cord attachment site. The omphalocele was characterized by the accumulation of the proteoglycan versican along with reduced proteolysis and impaired development of the superficial muscle layer, the panniculus carnosus, around the site of umbilical cord attachment. Furthermore, we observed sustained expression of the transcription factor, paired-like homeodomain transcription factor 2 in KO embryos, whereas it was downregulated in wild-type embryos during late embryogenesis. ADAMTS1 is thus a new matrisome component required for body wall closure. - Source: PubMed
Publication date: 2026/04/28
Opoku GabrielIkemura KentaroHatipoglu Omer FOhtsuki TakashiSato IkumiTaniguchi HibikiSakamoto ShinoHasib FarhanaWatanabe ShogoMead Timothy JApte Suneel SHirohata Satoshi