Mouse polyclonal to GATA3, Host Mouse
- Known as:
- Mouse pab GATA3, Host Mouse
- Catalog number:
- YF-PA11955
- Product Quantity:
- 50 uL
- Category:
- -
- Supplier:
- Abfron
- Gene target:
- Mouse polyclonal GATA3 Host
Related genes to: Mouse polyclonal to GATA3, Host Mouse
- Gene:
- GATA3 NIH gene
- Name:
- GATA binding protein 3
- Previous symbol:
- -
- Synonyms:
- HDR
- Chromosome:
- 10p14
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-03
- Date modifiied:
- 2016-10-05
Related products to: Mouse polyclonal to GATA3, Host Mouse
Related articles to: Mouse polyclonal to GATA3, Host Mouse
- Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterised by loss of immune tolerance and chronic inflammation, but its molecular pathogenesis remains incompletely understood. In this work we examine whether immune regulatory transcripts and pathways are recurrently detectable across heterogeneous publicly available SLE transcriptomic datasets, and we explore one of the recurrent pathways with a kinetic systems-biology model. We analyzed one microarray dataset (E-GEOD-46923, profiled on Affymetrix HG-U133A and HG-U133B), two bulk RNA-seq datasets (E-MTAB-7145, E-MTAB-11919), and two single-cell RNA-seq datasets (GSE135779, GSE163121) using a unified differential-expression criterion (|log2 fold change|≥ 1, Benjamini-Hochberg adjusted p-value < 0.05). KEGG pathway enrichment was performed with a per-dataset background gene universe. A mass-action kinetic model of Th1/Th2 differentiation was constructed in MATLAB SimBiology, and global sensitivity analysis was performed using the variance-based Sobol method. Across the heterogeneous datasets, CD53, IFITM1, and RPL11 were recurrently identified as differentially expressed transcripts, and the Th1/Th2 cell differentiation pathway, together with related cytokine-cytokine receptor and JAK-STAT pathways, emerged as a recurrent immune-regulatory signal. Systems-biology simulation under SLE-derived initial conditions predicted atypical IL-2 and GATA3 expression dynamics, which is consistent with, but does not by itself prove, the cytokine-signalling dysregulation reported in SLE. Sobol sensitivity analysis identified IL-4 and the modelled co-stimulatory and Notch ligand species (CDN1-6 and Jagged1/2) as the largest non-additive regulators of IL-2 in the model. Overall, this work integrates transcriptomic recurrence analysis with kinetic modelling to generate testable hypotheses regarding immune regulatory dysfunction in SLE. - Source: PubMed
Publication date: 2026/06/15
Saleem KashifParacha Rehan ZafarKhalid LintaManzoor AyeshaNisar MaryumMurad DidarDin Nazar MuhammadAmir Afreenish - Two traditional Chinese medicine (TCM) formulas are Guilu Erxian Glue (GEG) and Danggui Buxue Tang (DBT). Their combination, Modified Guilu Erxian Glue (MGEG), is used to treat aplastic anemia (AA). This study aims to clarify how MGEG restores immune tolerance in AA mice. Specifically, we studied whether MGEG can regulate the differentiation and maturation of T cell lineage by regulating the transcription of miR-146a to rebuild the stable state of bone marrow immune microenvironment, inhibit the immune response mediated by T helper (Th)1 cells, and enhance the immunosuppressive function of regulatory T cells (Tregs). - Source: PubMed
Publication date: 2026/05/29
Zhang YingkaiBai DongtianSun SongLiu WeiZhang PingxinNiu JingminSang JinghaoLi DongyangLiu JuanChai Limin - Occult breast cancer (OBC) is a rare clinical entity characterized by metastatic disease in the absence of an identifiable primary breast lesion. Metastases to the thyroid gland are rare. Breast carcinoma infrequently metastasizes to the thyroid, and cases arising from OBC are exceptionally uncommon, posing a significant diagnostic challenge. We report the case of a 63-year-old woman with no prior history of malignancy who presented with diffuse abdominal pain, headache, and neck stiffness. A thyroid nodule was identified during diagnostic evaluation. Ultrasonography demonstrated a hypoechoic lesion with irregular margins, and core needle biopsy suggested malignancy. Immunohistochemical (IHC) analysis showed positivity for estrogen receptor (ER), progesterone receptor (PR), mammaglobin, and GATA3, with negativity for thyroglobulin (TG), PAX8, and thyroid transcription factor-1 (TTF-1), supporting a breast origin. Mammography and breast ultrasonography were negative. Breast magnetic resonance imaging (MRI) was not performed due to rapid clinical deterioration. During hospitalization, she developed a generalized tonic-clonic seizure. Imaging revealed multiple brain metastases, indicating advanced disease. This case underscores the diagnostic complexity of thyroid lesions and highlights the necessity of considering metastatic disease, particularly in the context of OBC. Accurate diagnosis requires comprehensive histopathological assessment supported by immunohistochemical profiling to reliably distinguish metastatic involvement from primary thyroid malignancies. Prompt recognition is crucial to inform optimal therapeutic decision-making in these challenging clinical scenarios. - Source: PubMed
Publication date: 2026/05/13
Milonaki DespoinaPantoula PanagiotaProvatas IoannisFourlopoulou ArgyroSinou Nikoleta - Mucinous cystic tumors of the renal pelvis or pyelocaliceal system are extremely rare neoplasms and often mimic complicated renal cysts. Surgical resection is recommended due to the risk of malignant transformation. In September 2023, imaging revealed a cystic lesion measuring 106×93 mm in the right kidney of a 68-year-old male patient, reported as Bosniak type III. The patient underwent right radical nephrectomy. Pathological examination revealed a unilocular cystic lesion lined with mucinous epithelium showing no atypia. Immunohistochemically, epithelial cells were CDX2 positive and PAX8, GATA3, and p63 negative. Findings were consistent with mucinous cystadenoma. No recurrence or metastasis was observed during 18 months of follow-up. The diagnosis of renal mucinous cystadenoma is challenging with preoperative imaging, and the definitive diagnosis is made by postoperative histopathology. Surgical resection and close follow-up are necessary due to the risk of malignant transformation. - Source: PubMed
Publication date: 2026/05/12
Karadeniz Muhammed NDemir MehmetOtlu HasanAlmuhammed MuhammedCoskun Ferhat - The chromatin organizer SATB1 is indispensable for thymic regulatory T cell (Treg cell) development and T helper cell induction. Several gene loci have been described to be SATB1-controlled, including the transcription factor GATA3 and the cytokine loci IL-4 and IL-17. However, the global effects of SATB1 on fully differentiated human CD4 conventional T cells (Tconv cells) and Treg cells, and thus the potential of SATB1 as a target for T-cell engineering, are poorly understood. Here, we describe SATB1-regulated gene signatures as largely subset-specific, with broader effects on Treg cells. Despite distinct gene-regulatory patterns, we observe overarching dysregulated cytokine and JAK-STAT signaling after SATB1 ablation. Functionally, SATB1 KO reduces suppressive capacities of human Treg cells but boosts tumor clearance via CD4 CAR T cells in a preclinical, humanized mouse model. Taken together, Treg destabilization and simultaneous increased activation of CD4 CAR T cells by SATB1 modulation may be a strategy to boost the efficiency of CAR T cell therapies. - Source: PubMed
Publication date: 2026/06/12
Kolb SaskiaDiekmann LeonieLochert Elizabeth EWarmuth LindaRitter JuliaSchmidtke GunterWeber MichaelHoffmann MarkusList MarkusKotlarz DanielSerr IsabelleDaniel CarolinBusch Dirk HSchmidl ChristianSchumann Kathrin