Recombinant Human IL-11
- Known as:
- Recombinant Human Interleukin-11
- Catalog number:
- SJB01-04
- Product Quantity:
- 50μg/vial
- Category:
- -
- Supplier:
- Cytokin.
- Gene target:
- Recombinant Human IL-11
Related genes to: Recombinant Human IL-11
- Gene:
- IL11 NIH gene
- Name:
- interleukin 11
- Previous symbol:
- -
- Synonyms:
- IL-11, AGIF
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2016-10-11
Related products to: Recombinant Human IL-11
Related articles to: Recombinant Human IL-11
- The immunosuppressive tumor microenvironment (TME) represents a major barrier to effective hepatocellular carcinoma (HCC) therapy. While interleukin-11 (IL-11) has been implicated in cancer progression, its immunomodulatory functions and underlying mechanisms in HCC remain poorly understood. - Source: PubMed
Publication date: 2026/09/17
Gao YangYao XijuanHuang XingWang LianWang YongZhu GuangyuWang ZhenLi LuGuo JinheLu Jian - Excessive conjunctival fibroblast proliferation is a major factor in postoperative scarring following ophthalmic surgery. While Rebamipide is clinically used for dry eye and has anti-inflammatory effects, its direct impact on the transcriptomic profiles and inflammatory signaling of conjunctival fibroblasts remains unclear. We aimed to elucidate the gene expression pathways by which Rebamipide modulates the inflammatory and fibrotic responses of Primary Human Conjunctival Fibroblasts (HCFCs). - Source: PubMed
Publication date: 2026/09/09
Kinari GenTagami MizukiKira YukimiHaruna YusukeMisawa NorihikoMizukami YoichiHonda Shigeru - In this study, we demonstrate that during diabetic wound healing, interleukin-11 (IL-11) promotes the M1 polarization of macrophages, which subsequently triggers fibroblast senescence through the enhanced release of pro-inflammatory cytokines IL-1β and IL-6. Notably, Rhoifolin (Rho) effectively inhibits IL-11-induced M1 polarization, alleviates the secretion of IL-1β and IL-6, and concurrently promotes the release of choline, thereby mitigating fibroblast senescence. Based on these mechanistic findings, we constructed a targeted delivery system by loading Rho into mesoporous silica nanoparticles and coating them with macrophage membranes (M-Rho). The M-Rho were then incorporated into a poly(L-lysine)-grafted hyperbranched poly(amidoamine) (PLL-g-HPA) hydrogel to fabricate microneedles (Gel@M-Rho MN). This integrated system enables macrophage targeting, controlled drug release, favorable mechanical properties, and excellent biocompatibility. Moreover, the system exhibits potent reactive oxygen species (ROS)-scavenging activity and effectively inhibits the growth of Escherichia coli and Staphylococcus aureus. In vivo animal studies confirmed that Gel@M-Rho MN significantly promotes M2 macrophage polarization, suppresses fibroblast senescence, and accelerates wound closure, angiogenesis, and collagen deposition. Collectively, this strategy, which modulates macrophage-fibroblast crosstalk, offers a multi-mechanistic synergistic therapeutic approach for diabetic wounds, holding substantial potential for clinical translation. - Source: PubMed
Publication date: 2026/09/16
Liao JiewenGan LinLu LiOuyang LizhiXiong YuanAl-Smadi FawwazDai GuandongShahbazi Mohammad-AliMi BobinLiu MengfeiLiu Guohui - Pararamosis, or pararama-associated phalangeal periarthritis, is a neglected tropical disease affecting rubber tappers in the Amazon, caused by contact with the urticating bristles of the caterpillar. This condition leads to chronic synovitis and progressive cartilage degradation, key features shared with other osteoarticular conditions such as osteoarthritis. - Source: PubMed
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