Anti_HTLV_I p19 Clone TP_7
- Known as:
- Anti_HTLV_I p19 Clone TP_7
- Catalog number:
- GEN0801003
- Product Quantity:
- 100 µg
- Category:
- -
- Supplier:
- Bio-gentaur
- Gene target:
- Anti_HTLV_I p19 Clone TP_7
Related genes to: Anti_HTLV_I p19 Clone TP_7
- Gene:
- EXOC3L2 NIH gene
- Name:
- exocyst complex component 3 like 2
- Previous symbol:
- -
- Synonyms:
- FLJ36147, XTP7
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2007-01-19
- Date modifiied:
- 2017-05-11
- Gene:
- MST1L NIH gene
- Name:
- macrophage stimulating 1 like
- Previous symbol:
- MSTP7, MSTP9, MST1P9
- Synonyms:
- D1F15S1A, MSPL7, MSPL-7
- Chromosome:
- 1p36.13
- Locus Type:
- unknown
- Date approved:
- 1999-09-09
- Date modifiied:
- 2016-10-05
- Gene:
- SLC25A5P7 NIH gene
- Name:
- solute carrier family 25 member 5 pseudogene 7
- Previous symbol:
- ANTP7
- Synonyms:
- -
- Chromosome:
- 6q22.31
- Locus Type:
- pseudogene
- Date approved:
- 1991-11-21
- Date modifiied:
- 2016-02-18
- Gene:
- TP63 NIH gene
- Name:
- tumor protein p63
- Previous symbol:
- TP73L, TP53L, TP53CP
- Synonyms:
- p51, SHFM4, EEC3, p63, p73L, OFC8, KET, p73H, NBP, p53CP
- Chromosome:
- 3q28
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-18
- Date modifiied:
- 2019-04-23
- Gene:
- WDR46 NIH gene
- Name:
- WD repeat domain 46
- Previous symbol:
- C6orf11
- Synonyms:
- BING4, UTP7
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-06
- Date modifiied:
- 2016-10-05
Related products to: Anti_HTLV_I p19 Clone TP_7
Related articles to: Anti_HTLV_I p19 Clone TP_7
- Over 80% of patients with pancreatic cancer experience cachexia, characterized by severe muscle and fat loss. While all the mechanistic understanding comes from preclinical models, the translatable nature of these findings to humans remains a critical gap due to the limited knowledge of human cachexia biology. - Source: PubMed
Publication date: 2025/09/04
Narasimhan AshokZhong XiaolingCounts Brittany RYoung AndrewCao ShaWan JunLiu ShengKoniaris Leonidas GZimmers Teresa A - Hepatitis B virus (HBV) X protein (HBx) is critical in hepatocellular carcinoma (HCC) development, but its influence on tumor immunity and the tumor microenvironment (TME) remains unclear. This study aimed to construct a prognostic model based on HBx-related genes and explore their relationship with immune infiltration and immunotherapy response. Through transcriptome sequencing of our HBx-expressing HepG2 cells and analysis of HCC patient data from the cancer genome atlas (TCGA) and genotype-tissue expression (GTEx), we identified seven HBx-related genes, nuclear VCP-like (NVL), WD repeat domain 75 (WDR75), NOP58 nucleolar protein (NOP58), Brix domain-containing protein 1 (BRIX1), deoxynucleotidyltransferase terminal interacting protein 2 (DNTTIP2), MKI67 FHA domain interacting nucleolar phosphoprotein (NIFK), and ribosome production factor 2 (RPF2), associated with poor prognosis. LASSO Cox regression narrowed these to four key genes (BRIX1, RPF2, DNTTIP2, and WDR75), which were used to develop a prognostic riskscore signature. High-risk patients exhibited lower survival rates, decreased infiltration of anti-tumor immune cells, poorer responses to immunotherapy, and increased immune evasion. Among the four genes, DNTTIP2 showed higher expression in single-cell data, was linked to migration inhibitory factor (MIF) signaling, and may play a pivotal role in shaping an immunosuppressive TME. Elevated DNTTIP2 expression was confirmed in HBx-expressing HepG2 cells and HBV-infected HCC samples. This study highlights a novel HBx-related four-gene prognostic model that predicts clinical outcomes, immune infiltration, and immunotherapy response, offering insights into HCC progression and potential therapeutic targets. - Source: PubMed
Publication date: 2025/06/27
Zhong JianhuaLi YuetongLiu YangQiao JieWu YilingKong XinyiQi MiaoLin YiqiYao YaqiJin YingBi ChanglongZhai Aixia - Ribosomes, vital for life, consist of a large subunit and a small subunit (SSU), the latter is crucial for translation initiation and mRNA binding. The SSU processome, a 71-protein multimer in humans, is an intermediate in ribosome formation. One of its constituents, WDR75 plays a pivotal role by binding to an evolutionary conserved motif in the external transcribed spacer region of the rRNA to help form the SSU. Herein, we explore mammalian WDR75 molecular evolution, 3D structure, and phylogeny in light of its essential role in the SSU processome. We predict to find the footprint of purifying selection, especially at sites that are essential for proper ribosome assembly. In our comparison of 70 mammalian WDR75 sequences, we found ~25% of sites with significant purifying selection and no evidence of positive selection. Purifying selection was ~5x stronger for sites folding into beta-sheets than those predicted to be coils. Phylogenetic analysis validated expected mammalian relationships and uncovered an unusually long branch leading to mouse-eared bats, exhibiting 18x more substitutions per site than the average mammalian substitution rate. In testing for molecular evolution among branches, we found no evidence for purifying selection along any individual branches, but unexpectedly detected significant diversifying selection solely among African great apes. - Source: PubMed
Publication date: 2025/02/11
Lee LaurenWhittall Justen B - Neonatal mammalian hearts are capable of regenerating by inducing cardiomyocyte proliferation after injury. However, this regenerative capability in adult mammalian hearts almost disappears. Extracellular vesicles (EVs) have been shown to play vital cardioprotective roles in heart repair. Here, we report that EVs from regenerating neonatal heart tissues, after apical resection surgery (AR-Neo-EVs), exhibit stronger pro-proliferative, anti-apoptotic, and pro-angiogenesis activities than EVs from neonatal mouse cardiac tissues (Neo-EVs), effects which are absent in adult mouse heart-derived EVs (Adu-EVs). Proteomic analysis reveals the expression of Wdr75 protein, a regulator of p53, is higher in AR-Neo-EVs than in Neo-EVs. It is shown the regenerative potential of AR-Neo-EVs is abrogated when Wdr75 is knocked down. We further show that delivery of AR-Neo-EVs by sodium alginate hydrogel microspheres is an effective treatment in myocardial infraction. This work shows the potential of using EVs from regenerating tissue to trigger protective and regenerative mechanisms. - Source: PubMed
Publication date: 2025/02/03
Li HanjingLiu YiningLin YuqingLi SijiaLiu ChenluCai AoLi WeiZhang WanyuGao XinluRen ZhongyuJi HaoyuYu YangWang XiuxiuMa WenyaWang NingZhao DanLi TianlongLiu YuCai Benzhi - Sepsis-induced myopathy is one of the serious complications of sepsis, which severely affects the respiratory and peripheral motor systems of patients, reduces their quality of life, and jeopardizes their lives, as evidenced by muscle atrophy, loss of strength, and impaired regeneration after injury. The pathogenesis of sepsis-induced myopathy is complex, mainly including cytokine action, enhances free radical production in muscle, increases muscle protein hydrolysis, and decreases skeletal muscle protein synthesis, etc. The above mechanisms have been demonstrated in existing studies. However, it is still unclear how the overall pattern of gene co-expression affects the pathological process of sepsis-induced myopathy. Therefore, we intend to identify hub genes and signaling pathways. Weighted gene co-expression network analysis was our main approach to study gene expression profiles: skeletal muscle transcriptome in ICU patients with sepsis-induced multi-organ failure (GSE13205). After data pre-processing, about 15,181 genes were used to identify 13 co-expression modules. Then, 16 genes (FEM1B, KLHDC3, GPX3, NIFK, GNL2, EBNA1BP2, PES1, FBP2, PFKP, BYSL, HEATR1, WDR75, TBL3, and WDR43) were selected as the hub genes including 3 up-regulated genes and 13 down-regulated genes. Then, Gene Set Enrichment Analysis was performed to show that the hub genes were closely associated with skeletal muscle dysfunction, necrotic and apoptotic skeletal myoblasts, and apoptosis in sepsis-induced myopathy. Overall, 16 candidate biomarkers were certified as reliable features for more in-depth exploration of sepsis-induced myopathy in basic and clinical studies. - Source: PubMed
Publication date: 2024/10/22
Wang JianhaoHan KunLu Jinshuai