Rat IL21 protein Proteins
- Known as:
- Rat IL21 protein Proteins
- Catalog number:
- orb82622
- Product Quantity:
- 2
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- Rat IL21 protein Proteins
Related genes to: Rat IL21 protein Proteins
- Gene:
- IL21 NIH gene
- Name:
- interleukin 21
- Previous symbol:
- -
- Synonyms:
- Za11, IL-21
- Chromosome:
- 4q27
- Locus Type:
- gene with protein product
- Date approved:
- 2000-03-29
- Date modifiied:
- 2019-04-23
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- - Source: PubMed
Steffin DavidCourtney Amy NChoe MichelleGhatwai NishaEsparza Cerda Magdalena ASweidan RamyDhanashree RajdekarZhang HuiminLapteva NatashaMei ZhuyongGrilley Bambi JMetelitsa Leonid SHeslop Helen EBrenner Malcolm KHeczey Andras - Cytokines used during chimeric antigen receptor (CAR) T-cell manufacturing can influence product differentiation and functional fitness. - Source: PubMed
Publication date: 2026/08/25
Val-Casals MariaAltuna AnePérez-Amill LorenaArmand-Ugón MercedesPeña SergioLópez-Pecino AnaColomer DolorsEsteve JordiJuan ManelKlein-González Nela - Chronic periodontitis (CP) is an inflammatory-destructive disease, and Th17 cells play a vital role in driving and regulating CP. This study aimed to confirm the influence of miR-3917/HLA-DRB1 in the differentiation of CD4 T cells to Th17 cells. The differentially expressed microRNAs (miRNAs) in CP were screened from the Gene Expression Omnibus (GEO) database, and then the target gene of miR-3917 was confirmed by using the RT-qPCR and Dual-Luciferase assay. clinical data of patients with CP and healthy individuals were collected, and intergroup comparisons were performed using ROC and logistic regression analysis. A CD4T cell differentiation model was established to explore the role of the miR-3917/HLA-DRB1 axis in regulating CD4T cell differentiation into Th17 cells. STAT3 and RORγt levels were detected by RT-qPCR and WB. Production of IL-17 and IL-21 was determined by ELISA kits. MiR-3917 upregulation and HLA-DRB1 downregulation were detected in patients with CP. Overexpression of miR-3917 promoted the differentiation of CD4T cells toward Th17 cells, boosted the secretion of IL-17 and IL-21, and elevated the levels of STAT3 and RORγt, whereas inhibition of miR-3917 exerted the opposite effects. Rescue experiment confirmed that miR-3917 increased Th17 cell differentiation by directly targeting and regulating HLA-DRB1. MiR-3917 downregulated HLA-DRB1, thereby promoting Th17 cell differentiation and ultimately aggravating inflammation. These findings suggested that miR-3917 may be involved in CP pathogenesis and might serve as a potential diagnostic biomarker for CP. - Source: PubMed
Publication date: 2026/09/08
OuYang YuLuLi QiyanXie HuiminZhang TingtingDai Zhenhua - The functional status of regulatory T cells expressing the gut-homing receptor CCR9 (CCR9 Tregs) in type 1 diabetes mellitus (T1DM) remains unclear. This study aims to investigate the functional alterations of CCR9 Tregs in a T1DM model and evaluate the interventional effect of targeting the IL-21/IL-17 axis on their dysfunction. - Source: PubMed
Publication date: 2026/08/30
Xia YulianHe QingYao YuhuiYang LeiZhan ShanshanMao Shunfeng - HIV-1 reservoirs are predominantly located in CD4+ T-cells; however, not all CD4+ T-cells contribute to the reservoir in the same way. Factors such as activation, differentiation, and cell metabolism have been proposed to determine the relative susceptibility of cells to HIV-1 infection. HIV-1 reservoirs are seeded early during the acute phase of infection, but the cell composition of these reservoirs evolves in the transition to chronic infection. This suggests that there are factors during the acute phase that may alter the intrinsic susceptibility of CD4+ T-cells to HIV-1. We investigated here the influence of common cytokines known to be secreted during the acute phase and to play a role in either T cell homeostasis or HIV-1 infection on activation, differentiation, metabolic activity, and HIV-1 susceptibility of CD4+ T-cells. We show that the proinflammatory cytokines interleukin (IL)-2, IL-7, and IL-15 induce cellular activation, differentiation to effector profile, increase in metabolic capacity, and HIV-1 susceptibility. In contrast, IL-21, another cytokine from the gamma-chain (γc) family, showed opposing effects on the same parameters, including decreasing oxidative phosphorylation (OXPHOS) and HIV-1 infection. We also show that IL-10 and interferon (IFN)-α are able to at least partially revert the cellular and metabolic changes induced by IL-2 or IL-7 and reduce the cells' susceptibility to HIV-1. - Source: PubMed
Elfidha AmalDe la Torre Tarazona ErickPassaes CarolineAlcamí JoséMüller-Trutwin MichaelaSáez-Cirión Asier