Rat IL11 ELISA kit
- Known as:
- Rat IL11 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- orb59179
- Product Quantity:
- 96 wells
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- Rat IL11 ELISA kit
Related genes to: Rat IL11 ELISA kit
- Gene:
- IL11 NIH gene
- Name:
- interleukin 11
- Previous symbol:
- -
- Synonyms:
- IL-11, AGIF
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2016-10-11
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- In this study, we demonstrate that during diabetic wound healing, interleukin-11 (IL-11) promotes the M1 polarization of macrophages, which subsequently triggers fibroblast senescence through the enhanced release of pro-inflammatory cytokines IL-1β and IL-6. Notably, Rhoifolin (Rho) effectively inhibits IL-11-induced M1 polarization, alleviates the secretion of IL-1β and IL-6, and concurrently promotes the release of choline, thereby mitigating fibroblast senescence. Based on these mechanistic findings, we constructed a targeted delivery system by loading Rho into mesoporous silica nanoparticles and coating them with macrophage membranes (M-Rho). The M-Rho were then incorporated into a poly(L-lysine)-grafted hyperbranched poly(amidoamine) (PLL-g-HPA) hydrogel to fabricate microneedles (Gel@M-Rho MN). This integrated system enables macrophage targeting, controlled drug release, favorable mechanical properties, and excellent biocompatibility. Moreover, the system exhibits potent reactive oxygen species (ROS)-scavenging activity and effectively inhibits the growth of Escherichia coli and Staphylococcus aureus. In vivo animal studies confirmed that Gel@M-Rho MN significantly promotes M2 macrophage polarization, suppresses fibroblast senescence, and accelerates wound closure, angiogenesis, and collagen deposition. Collectively, this strategy, which modulates macrophage-fibroblast crosstalk, offers a multi-mechanistic synergistic therapeutic approach for diabetic wounds, holding substantial potential for clinical translation. - Source: PubMed
Publication date: 2026/09/16
Liao JiewenGan LinLu LiOuyang LizhiXiong YuanAl-Smadi FawwazDai GuandongShahbazi Mohammad-AliMi BobinLiu MengfeiLiu Guohui - Pararamosis, or pararama-associated phalangeal periarthritis, is a neglected tropical disease affecting rubber tappers in the Amazon, caused by contact with the urticating bristles of the caterpillar. This condition leads to chronic synovitis and progressive cartilage degradation, key features shared with other osteoarticular conditions such as osteoarthritis. - Source: PubMed
Publication date: 2026/08/25
Pohl Paula CZapotoski Luiza N KSardinha Luiz RVillas-Boas Isadora MPidde GiselleTambourgi Denise V - Prostate cancer (PCa) and Alzheimer's disease (AD) are age-related disorders with a complex epidemiological association and limited therapeutic options. Identifying shared molecular drivers may reveal new treatment targets. - Source: PubMed
Publication date: 2026/08/20
Wang MengxueQian YanrongHuang EnyaoChu ChunyanGao TianChen ShengrongZhao NaLuo CaichenLiu YifanZheng XiejunhaoHu HaowenHan BowenChen MingMao WeipuLi Wenchao - Microglia are the main targets of HIV-1 infection in the central nervous system (CNS) and are considered important contributors to chronic neuroinflammation in people living with HIV (PLWH). In this study, we investigated the mechanisms leading to inflammatory responses during acute HIV-1 infection in an adult human microglia model. - Source: PubMed
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Gaete-Argel AracellyAnanías-Sáez CatarinaRojas-Fuentes CeciliaGiraldo-Ocampo SebastianJara DanielaHernández-Díaz TomásOrtega-Orellana CamilaLópez-Palma DeliaAkiyama HisashiGummuluru SuryaramGonzález Pablo AValiente-Echeverría FernandoSoto-Rifo Ricardo - Chronic renal allograft dysfunction (CRAD) continues to limit the long-term survival of transplanted kidneys. Inflammatory cell accumulation during the early phase of CRAD may accelerate fibrotic remodeling and graft dysfunction, although the regulatory mechanisms driving this process have not been fully clarified. Interleukin-11 (IL-11) is increasingly recognized as a fibro-inflammatory mediator, but whether miRNA-dependent regulation of IL-11 participates in early CRAD-associated inflammation remains unknown. This study aimed to investigate whether miR-204-5p regulates early inflammatory injury in CRAD by targeting IL-11. - Source: PubMed
Publication date: 2026/08/11
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