PLA2G4D antibody Polyclonal Antibodies Primary antibodies
- Known as:
- PLA2G4D (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb120709
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- PLA2G4D antibody Polyclonal Antibodies Primary antibodies
Related genes to: PLA2G4D antibody Polyclonal Antibodies Primary antibodies
- Gene:
- PLA2G4D NIH gene
- Name:
- phospholipase A2 group IVD
- Previous symbol:
- -
- Synonyms:
- cPLA2delta
- Chromosome:
- 15q14
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-04
- Date modifiied:
- 2015-11-18
Related products to: PLA2G4D antibody Polyclonal Antibodies Primary antibodies
Related articles to: PLA2G4D antibody Polyclonal Antibodies Primary antibodies
- BACKGROUND: Familial hypercholesterolemia (FH) is a genetic disorder characterized by imbalances in lipid metabolism, markedly increasing cardiovascular risk. Identifying lipid metabolism-related biomarkers is essential for understanding FH pathogenesis and developing therapeutic strategies. METHODS: A comprehensive bioinformatics analysis was conducted using 776 lipid metabolism-related genes (LMRGs) from the MSigDB database and the GSE6054 dataset containing 10 FH and 13 healthy samples. Differentially expressed genes (DEGs) intersected with LMRGs to obtain candidate genes, followed by random forest and SVM-RFE machine learning to identify key biomarkers. Functional enrichment, subcellular localization, co-expression, transcription factor (TF) prediction, ceRNA network, and drug screening were subsequently performed. RESULTS: We identified 429 DEGs and 13 candidate genes, refined to six key genes (STAR, GRHL1, BZRAP1, LGMN, PLA2G4D, PLA2G12B). ROC analysis demonstrated that all six key genes exhibited AUC values greater than 0.7, underscoring their diagnostic potential. Functional enrichment further revealed significant associations with the ribosome and spliceosome pathways. Subcellular localization suggested mitochondrial and extracellular functions. Co-expression showed a significant positive correlation between GRHL1 and PLA2G12B. TF prediction revealed 17 TF-gene interactions, while ceRNA analysis outlined regulatory relationships. Drug prediction identified 224 potential therapeutic compounds, with STAR showing the most interactions. CONCLUSION: This study highlights six lipid metabolism-related biomarkers in FH through integrated bioinformatics and machine learning. These findings provide new insights into FH mechanisms and potential therapeutic targets. - Source: PubMed
Publication date: 2026/04/24
Long LinjiZhu BaoshengLv Tao - : Tracheobronchopathia osteochondroplastica (TO) is a rare benign disorder characterized by submucosal cartilaginous and osseous nodules of the tracheobronchial tree, typically sparing the posterior membranous wall. Involvement of the vocal cords is exceedingly rare and may result in critical airway obstruction. The underlying genetic and molecular mechanisms of TO remain largely unexplored. : We report a rare case of TO extending from the vocal cords to the bronchi in a 76-year-old man who initially presented with pneumonia and later developed acute respiratory failure due to severe airway narrowing, necessitating emergency tracheostomy. Bronchoscopy and computed tomography revealed diffuse calcified nodules involving the anterior and lateral airway walls, including the subglottic region. Histopathology demonstrated chronic inflammatory cell infiltration with squamous metaplasia. To explore the molecular basis of this condition, whole-genome sequencing (WGS) was performed using peripheral blood samples-the first such application in TO. WGS identified 766 germline mutations (including 27 high-impact variants) and 66 structural variations. Candidate genes were implicated in coagulation and inflammation (), arachidonic acid metabolism and extracellular matrix remodeling (), ciliary dysfunction and mineralization (), vascular calcification (), smooth muscle function (), abnormal calcification (), fibrotic signaling (), and mucosal barrier integrity (). Notably, despite systemic germline mutations, calcification was restricted to the airway. : This case highlights that TO with vocal cord involvement can progress beyond a benign course to cause life-threatening airway obstruction. Integrating clinical, histological, and genomic findings, we propose a novel pathophysiological model in which systemic genetic susceptibility interacts with local immune cell infiltration and fibroblast-driven extracellular matrix remodeling, resulting in airway-restricted dystrophic calcification. This first genomic characterization of TO provides new insights into its pathogenesis and suggests that multi-omics approaches may enable future precision medicine strategies for this rare airway disease. - Source: PubMed
Publication date: 2026/01/09
Park YeonheeLee Joo-EunLim Mi JungKang Hyeong SeokChung Chaeuk - Psoriasis is frequently associated with dyslipidemia, yet the role of specific unsaturated fatty acid (UFA) metabolic pathways in disease pathogenesis and treatment response remains poorly understood. This study aimed to characterize the landscape of UFA metabolic reprogramming in psoriasis and evaluate its clinical relevance for predicting response to biologic therapy. - Source: PubMed
Publication date: 2025/12/18
Miao HaijunGuan XiaojuanLi LiangliangWang LixingLuo Yang - BACKGROUND: Glioma is the most malignant intracranial tumor. Transient receptor potential (TRP) channel family has been found to be involved in malignant progression of many tumors. However, the relationship between TRP channel-related genes (TCRGs) and glioma remains unclear. METHODS: Gene expression profiles and clinical data of 1,475 glioma patients were obtained from TCGA, CGGA, and GEO databases. Prognostic TCRGs were screened and used to classify the patients. Lasso Cox regression analysis was used to construct a risk model, which was validated in external cohorts, and the patients were stratified into high- and low-risk groups. Immune infiltration and functional enrichment analyses were performed to explore the tumor microenvironment in two groups, while drug sensitivity predictions were conducted. Single-cell RNA sequencing data were analyzed to examine the cell type-specific expression of key model genes. Finally, RT-qPCR was performed on paired glioma and adjacent normal tissues to validate the expression of all model genes. RESULTS: Thirty-seven differentially expressed TCRGs were identified in glioma, of which 30 were associated with patient survival. Consensus clustering revealed three molecular subtypes with distinct prognoses, immune infiltration, and pathway enrichment. A 10-gene (TRPM6, PRKCB, CAMK2G, ADCY5, HTR2A, P2RY2, MAPK13, BDKRB1, PLA2G4D, and TRPV3) prognostic model stratified patients into high- and low-risk groups with significantly different overall survival, validated in external cohorts. High-risk patients exhibited higher immune cell infiltration and were predicted to be more sensitive to drugs including 5-Fluorouracil, Dasatinib, Gemcitabine, and Rapamycin, whereas low-risk patients were more sensitive to Vorinostat, Lapatinib, Gefitinib, and Osimertinib. Single-cell RNA sequencing showed that TRPV3 was expressed in exhausted CD8+ T cells, supporting the model’s relevance to tumor immunity and patient prognosis. RT-qPCR verification indicated that all 10 genes in the model were expressed at lower levels in glioma tissues. CONCLUSION: Based on the expression of TCRGs, we conducted the new subtype classification and a prognostic model for glioma, and is expected to provide theoretical basis for the development of new targets. - Source: PubMed
Publication date: 2025/12/02
Niu XiaochenGuo AijieLiu XuanchenLi HaoJi HongmingWang Chunhong - Psoriasis is a chronic and complex disease characterized by itching, burning, and soreness with scaly plaques and erythematous lesions. It is associated with various comorbidities, such as rheumatoid arthritis, cardiovascular disease, and psychiatric complications. Psoriasis is a systemic inflammatory disease that increases the release of pro-inflammatory cytokines from chronically-activated innate and adaptive immune systems. To treat multifactorial and complex diseases, system-oriented drug design and drug combinations for synergistic effects are highly effective and advantageous. Previous studies have revealed the immunomodulatory effects of Bojungikki-tang (BJT, Buzhong-Yiqi-Tang in traditional Chinese medicine and Hochu-ekki-to in Kampo medicine) in complex diseases; however, the effect of BJT on psoriasis, a chronic autoimmune disease, has not been evaluated. - Source: PubMed
Publication date: 2025/11/27
Kim Yun HeeKim Hye JinSong Hyun-KyungHwang Youn-HwanKim Yu JinJang SeolKim Bu-YeoKim Taesoo