CTNND1 antibody Monoclonal Antibodies Primary antibodies
- Known as:
- CTNND1 (anti-) Monoclonal Antibodies Primary antibodies
- Catalog number:
- orb45432
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- CTNND1 antibody Monoclonal Antibodies Primary antibodies
Related genes to: CTNND1 antibody Monoclonal Antibodies Primary antibodies
- Gene:
- CTNND1 NIH gene
- Name:
- catenin delta 1
- Previous symbol:
- CTNND
- Synonyms:
- KIAA0384, p120, p120cas, p120ctn
- Chromosome:
- 11q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-18
- Date modifiied:
- 2015-11-19
Related products to: CTNND1 antibody Monoclonal Antibodies Primary antibodies
Related articles to: CTNND1 antibody Monoclonal Antibodies Primary antibodies
- Cadherins are linked to actin through α- and β -catenin. p120 catenin (p120) also binds to the cadherin cytoplasmic domain and prevents cadherin endocytosis. In mouse epidermis, p120 gene ablation leads to severe skin inflammation and early postnatal lethality. These outcomes have been ascribed to cadherin-independent functions of p120 in RhoA and NFκB inflammatory signaling. However, the downregulation of cadherins in a p120 null background complicates interpretations. We engineered a mouse line in which a di-leucine endocytic motif in the E-cadherin cytoplasmic domain was mutated (EcadLL). Using tissue-level morphometric analyses in parallel to transcriptomics, we find that the EcadLL mutant is epistatic to p120 gene ablation. Mice lacking epidermal p120, but harboring the EcadLL mutant, are viable, fertile, and lack epidermal inflammation and hyperproliferation observed in p120 knock-out epidermis. These findings demonstrate that regulation of cadherin cell surface stability is the essential function of p120 and suggest a role for cadherins in suppressing epidermal inflammatory pathways. - Source: PubMed
Publication date: 2026/05/28
Schell Stephanie LSeo TadahikoXu HaifangSennett Mackenzie LDing KevinHelm Matthew FLanza MatthewNelson Amanda MKowalczyk Andrew P - Is E-cadherin (CDH1) expressed on the free apical surface of endometrial epithelial cells (EECs) involved in embryo attachment? - Source: PubMed
Ruan HanzhangChen Andy Chun HangXue YuxuanLee Kai ChuenFong Sze WanQiu QiTan YongqiFeng YingLee Cheuk LunHua RenwuHuang JunrongWang TianrenXu YanwenLee Kai-FaiXi NingLi Raymond Hang WunNg Ernest Hung YuYeung William Shu BiuLee Yin Lau - Familial exudative vitreoretinopathy (FEVR) is an inherited eye disease characterised by the incomplete development of the retinal vasculature. Over 10 genes have been associated with FEVR, but there are still a substantial number of genetically unsolved cases. The aim of this study was to analyse whole genome sequencing (WGS) data from the FEVR cases in the Genomics England (GEL) 100 000 genomes project to identify the causative variants. - Source: PubMed
Publication date: 2026/02/20
Sun DongHenderson Robert HClement EmmaMichaelides MichelKalitzeos AngelosWright Genevieve AMcloone EibhlinInglehearn ChrisPoulter James AToomes Carmel - The intratumor microenvironment shapes the metastatic potential of cancer cells and their susceptibility to any immune response. Yet, the nature of the signals within the microenvironment that control anticancer immunity and how they are regulated is poorly understood. Here, using melanoma as a model, we investigate the involvement in metastatic dissemination and the immune-modulatory microenvironment of Protein S-Acyl Transferases as an underexplored class of potential therapeutic targets. We find that ZDHHC13 suppresses metastatic dissemination by palmitoylation of CTNND1, leading to stabilization of E-cadherin. Importantly, ZDHHC13 also reshapes the tumor immune microenvironment by suppressing lysophosphatidylcholine (LPC) synthesis in melanoma cells, leading to inhibition of M2-like tumor-associated macrophages that we show degrade E-cadherin via MMP12 expression. Consequently, ZDHHC13 activity suppresses tumor growth and metastasis in immunocompetent mice. Our study highlights the therapeutic potential of targeting the ZDHHC13-E-cadherin axis and its downstream metabolic and immune-modulatory mechanisms, offering additional strategies to inhibit melanoma progression and metastasis. - Source: PubMed
Publication date: 2025/09/30
Li HongjinLyu JiankeSun YuYin ChengqianLi YuewenChen WeiqiangFoo Suan-SinWu XianfangGoding Colin RChen Shuyang - Panitumumab shows limited clinical benefit in colorectal cancer (CRC), and reliable predictive biomarkers to guide patient selection remain lacking. To address this gap, we investigated molecular determinants of therapeutic response using tumor samples from patients with primary and metastatic CRC. By integrating PIMS-based metastatic classification, NPOT interaction profiling and quantitative proteomics, this study aimed to identify response-associated pathways and potential prognostic biomarkers that could support improved stratification for panitumumab therapy. - Source: PubMed
Quartier AngeliqueSanin Ahmed YNagelschmitz JuliaSchneider JustineShi WenjieWartmann ThomasDölling MaximilianStelter FrederikeAndric MihailoCroner Roland SEftekhari PierreKahlert Ulf D