MALT EXTRACT POWDER (for bacteriology)
- Known as:
- MALT EXTRACT POWDER (to measure bacteriology)
- Catalog number:
- 1214
- Product Quantity:
- 500 gm
- Category:
- -
- Supplier:
- TitanBiotech
- Gene target:
- MALT EXTRACT POWDER (for bacteriology)
Related genes to: MALT EXTRACT POWDER (for bacteriology)
- Gene:
- BIRC3 NIH gene
- Name:
- baculoviral IAP repeat containing 3
- Previous symbol:
- API2
- Synonyms:
- cIAP2, hiap-1, MIHC, RNF49, MALT2, c-IAP2
- Chromosome:
- 11q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-10
- Date modifiied:
- 2016-10-05
- Gene:
- PIFO NIH gene
- Name:
- primary cilia formation
- Previous symbol:
- C1orf88
- Synonyms:
- FLJ23853, pitchfork
- Chromosome:
- 1p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-27
- Date modifiied:
- 2014-11-19
- Gene:
- TPT1 NIH gene
- Name:
- tumor protein, translationally-controlled 1
- Previous symbol:
- -
- Synonyms:
- TCTP, fortilin
- Chromosome:
- 13q14.13
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-17
- Date modifiied:
- 2016-10-05
Related products to: MALT EXTRACT POWDER (for bacteriology)
Related articles to: MALT EXTRACT POWDER (for bacteriology)
- Acute pancreatitis (AP) is a frequent exocrine inflammation of the pancreas that causes severe abdominal pain and multiorgan dysfunction that may lead to pancreatic necrosis and persistent organ failure. Previous studies have indicated that the pathogenesis of AP is based on the Cerulein-triggered experimental model, which simulates human AP in vivo. As reported, pancreatic acinar cells and peritoneal macrophages partake in pancreatic inflammation and injury. Nevertheless, the association between them is poorly understood. NLRC4 was highly expressed, and BIRC3 was reduced in AP patients and Cerulein-treated AR42J cells. Exosomes derived from Cerulein-treated AR42J cells induced rat peritoneal macrophage M1 polarization and pyroptosis, which were partly abolished by NLRC4 silencing. Moreover, BIRC3 triggered the ubiquitination of NLRC4 and promoted its degradation. Besides, exosomal BIRC3 repressed sodium taurocholate-induced pancreatic lesions in vivo. Exosomes derived from Cerulein-stimulated pancreatic acinar cells promote peritoneal macrophage M1 polarization and pyroptosis by a BIRC3/NLRC4 axis in AP, providing a promising strategy to protect against AP. - Source: PubMed
Publication date: 2026/05/01
Zhang ShengFu JunjingZhang HaiyunZhou BingZhou BinjieJiao Yang - Disease of the lung alveoli is frequently associated with acute or chronic inflammation. At present, there are no effective therapies to support regeneration of the alveolar epithelium, and ongoing inflammation adds an additional layer of complexity to many lung diseases. Here, we describe a primary adult human organoid model for investigating how inflammation shapes alveolar regeneration. Unlike previous models, this system supports long-term expansion of newly identified human-specific alveolar progenitor cells and serum-free differentiation into alveolar type 1 (AT1)-like cells. Using this platform, we find that interferon-gamma (IFN-γ) exerts cytotoxic effects on mature AT1-like cells while promoting survival of alveolar progenitor cells mediated by BIRC3. This unexpected selective positive effect of IFN-γ on alveolar progenitors underscores the need for nuanced and context-dependent evaluation of the influence of pro-inflammatory cytokines on alveolar regeneration. Our organoid model provides a reductionist platform for mechanistic studies and discovery of strategies to enhance alveolar regeneration. - Source: PubMed
Publication date: 2026/04/16
Dost Antonella F MBalážová KatarínaPou Casellas Carlavan Rooijen Lisanne MEpskamp Wissevan Son Gijs J Fvan de Wetering Willine JLopez-Iglesias CarmenBegthel HarryPeters Peter JSmakman Nielsvan Es Johan HClevers Hans - Glioblastoma (GBM) is an incurable tumor where temozolomide (TMZ) resistance limits survival, even in MGMT-methylated patients. To improve stratification, we used NAD(P)H-FLIM to profile TMZ response in 35 patient-derived explants, integrating these data with transcriptomic and functional analyses. We identified BIRC3 and CAV1 upregulation in resistant tumors and investigated their parallel yet functionally cooperative role in driving an aggressive, therapy-resistant phenotype. In silico survival analyses demonstrated that BIRC3 and CAV1 act as independent prognostic factors whose additive, non-linear effects robustly stratify patient survival beyond MGMT status, defining a subgroup with <7% 24-month survival. Importantly, BIRC3/cIAP2-driven resistance proved targetable; the IAP antagonist AZD5582 restored TMZ sensitivity by unlocking the apoptotic execution phase, thereby inducing cell death in resistant GBM models in vitro and ex vivo. Our findings establish the BIRC3/CAV1 axis as a key prognostic signature and therapeutic vulnerability in GBM, offering a new path for precision oncology strategies. - Source: PubMed
Publication date: 2026/04/14
Franceschi SaraMorelli MariangelaLessi FrancescaDi Lorenzo FrancescaAretini PaoloPastore AldoMarranci AndreaGambacciani CarloPieri FrancescoVillanacci FedericoMontemurro NicolaGiacomarra ManuelMenicagli MicheleFerri GianmarcoPasqualetti FrancescoKrengli MarcoSanson MarcPicca AlbertoDi Stefano Anna LuisaSantonocito Orazio SantoMazzanti Chiara Maria - Prostate cancer is one of the most prevalent malignancies among men and remains a major clinical challenge due to the complex tumor microenvironment. Understanding gene expression dynamics at both cellular and spatial levels is essential for improving therapeutic strategies. In this study, we performed an integrated multi-omics analysis using single-cell RNA sequencing and spatial transcriptomics. scRNA-seq data from 15 prostate samples, including 8 normal and 7 tumor tissues, were analyzed to characterize distinct cellular populations. Spatial transcriptomic profiling was conducted on three FFPE prostate tissue sections, including adjacent normal tissue, acinar cell carcinoma, and invasive adenocarcinoma, using the standard 10x Genomics Visium FFPE platform (55 µm capture spots). Single-cell analysis revealed heterogeneity among epithelial, stromal, and immune cell populations, highlighting complex signaling networks in which myeloid cells may contribute to tumor progression through immune suppression and epithelial adaptability. Spatial transcriptomic analysis further identified region-specific expression patterns and spatially restricted tumor niches, including the regional establishment of and as genes associated with metabolic stress and inflammatory survival pathways. The spatial colocalization of with tumor vasculature in invasive carcinoma tissue suggests a novel interaction. Our discoveries using an integrated single-cell and spatial transcriptomic approach reveal a high-resolution molecular map of prostate cancer with spatial features that may provide further therapeutic investigation. - Source: PubMed
Publication date: 2026/04/02
Hosseini Seyed TalebAzizi HosseinSkutella Thomas - Prostate cancer (PC) is one of the malignant tumors with high incidence and mortality worldwide in men. Immune cells in the tumor microenvironment (TME), particularly mast cells, play important roles in tumor progression and prognosis. However, the dual roles of mast cells in PC have not been fully elucidated. - Source: PubMed
Publication date: 2026/03/24
Fang RuizheZhao ShuyangSi MingguiZhang YinshiXu RuicongLi Jingjia