CCM2 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- CCM2 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb37132
- Product Quantity:
- 5
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- CCM2 antibody Polyclonal Antibodies Primary antibodies
Related genes to: CCM2 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- CCM2 NIH gene
- Name:
- CCM2 scaffold protein
- Previous symbol:
- C7orf22
- Synonyms:
- MGC4607, OSM
- Chromosome:
- 7p13
- Locus Type:
- gene with protein product
- Date approved:
- 2003-07-14
- Date modifiied:
- 2019-04-23
Related products to: CCM2 antibody Polyclonal Antibodies Primary antibodies
Related articles to: CCM2 antibody Polyclonal Antibodies Primary antibodies
- Hereditary cerebral cavernous malformations (CCMs) are characterized by lesion multiplicity and the formation of de novo lesions, in contrast to sporadic forms. We performed sequencing analyses covering the known autosomal dominant loci CCM1/KRIT1, CCM2/CCM2 (Malcavernin), and CCM3/PDCD10 in 11 patients from eight families with CCMs. All patients had multiple lesions, and de novo lesions were observed in four patients (36.4%). Heterozygous loss-of-function variants were identified in seven families, including four variants of KRIT1, two of CCM2, and one of PDCD10. Among them, c.1730 + 4_1730 + 7delAGTA in KRIT1 and c.609G>A (p.Lys203=) in CCM2 were putative splicing variants located outside the invariant GT/AG dinucleotides at the splice junction because AI-based prediction tools indicated that both variants may disrupt normal splicing. In vitro splicing assays confirmed that the AI-based predictions were correct, and the same aberrant splicing pattern was reproduced by reverse transcription PCR using tissue-derived RNA for the c.609G>A variant in CCM2. In one patient with numerous CCM lesions, whole-genome sequencing was performed, which showed no abnormalities in the three known CCM loci, including deep intronic and structural variants. This may indicate the technological limitations of current bioinformatics analyses or the presence of a novel CCM gene. - Source: PubMed
Publication date: 2026/09/24
Hori TakahiroTsutumi SatoshiHashimoto KazutoshiIshiguro TaichiOhbuchi HidenoriYamamoto YasunagaNomura EmiAzuma KenkoKubota YuichiAkagawa Hiroyuki - The cytoplasmic tails of HLA molecules are heterogeneous and polymorphic in terms of length and amino-acid sequences. We previously showed that class II HLA molecules transmitted signals in antigen presentation, and cross-linking HLA-DQ induced the interleukin (IL)-10 response of monocytes via p38MAPK. In this study, cross-linking DQ of B cells led to the phosphorylation of Ser-255 of Hsp90β. Hsp90 and casein kinase (CK) 2 which can catalyze this phosphorylation pattern, were co-immunoprecipitated with DQ. The long-form DQ tail-derived peptides bound to CK2 protein with higher affinity. The crosslinking-induced IL-10 response was suppressed by specific inhibition of Hsp90 and CK2. Furthermore, anti-Hsp90 antibody co-immunoprecipitated mitogen-activated protein kinase kinase kinase 3 (MEKK3) and cerebral cavernous malformations 2 (CCM2), a scaffold for p38MAPK activation. Cross-linking DQ augmented co-immunoprecipitation of MEKK3 with CCM2, in an Hsp90-dependent manner. HLA-DQ thereby qualitatively controls heterogeneous immune responses through its polymorphic tails via HLA-kinase-chaperone-scaffold-MAPK cascade signaling into antigen-presenting cells. Subjects with long-form DQ alleles showed elevated plasma IL-10 and IgG4 levels. These observations shed light on the novel non-classical function of HLA molecules. - Source: PubMed
Publication date: 2026/09/18
Matsushita ShoTakagi RieTokano MiekoNakagome KazuyukiSoma TomoyukiNagata MakotoKawano Masaaki - Organic ferroelectrics have emerged as a promising class of functional materials owing to their lightweight nature, structural flexibility, low processing temperatures, and environmentally benign composition. In this study, we report the synthesis and comprehensive characterization of guanidinium croconate, a new two-component organic salt obtained via acid-base neutralization of croconic acid and guanidine. Single-crystal x-ray diffraction reveals a polar crystal structure stabilized by an extensive three-dimensional N─H···O hydrogen-bonded network that supports long-range polar order. Macroscopic ferroelectricity is confirmed through polarization-electric field (P-E) hysteresis loops and positive-up-negative-down (PUND) measurements, yielding a remnant polarization of 3.5 µC/cm. Piezoresponse force microscopy (PFM) demonstrates clear ferroelectric domain structures, reversible 180° phase switching, and a converse piezoelectric coefficient (d) of 10-13.5 pm/V. Kurtz-Perry second-harmonic generation (SHG) measurements show an efficiency of 0.11 relative to KDP at room temperature. Variable-temperature SHG and differential scanning calorimetry reveal a strongly hysteretic ferroelectric-to-paraelectric phase transition at 510 K. Density functional theory calculations indicate a large molecular dipole moment of 12.56 D, arising from enhanced ionic charge separation. These results highlight ionic assembly as an effective strategy for designing hydrogen-bond-driven organic ferroelectrics. - Source: PubMed
Deka NilotpalIndad Md IzazulZaręba Jan KBoomishankar Ramamoorthy - Tactile-assisted perception systems hold great promise for robotics and human-machine interaction, yet current assistive systems for visually impaired individuals suffer from redundant data transmission, complex fusion algorithms, and high-power consumption. These limitations can introduce millisecond‑scale processing latencies and restrict hardware‑level dynamic adaptability, posing substantial challenges for complex scenarios such as temperature‑induced tactile blurring. Here, we propose a multimodal adaptive perception system based on a HfZrO (HZO) epitaxial thin-film ferroelectric memristor. The device features excellent ferroelectric properties with a remanent polarization of 2P ≈ 36.4 µC/cm, stable 16-state multilevel resistance, and robust synaptic plasticity for biomimetic emulation of biological learning rules. We developed adaptive sensing units integrating light, temperature, and pressure, which autonomously regulate response in dynamic environments. By encoding Braille digits into pulse sequences and adopting reservoir computing, we achieved a 91.65% maximum recognition accuracy for Braille digits 0-9. The system completes a single analog computation in ∼48 µs with only 8.51 nJ energy consumption, three orders of magnitude lower than conventional electronics. This work provides an efficient hardware strategy for neuromorphic perception and visually impaired assistive devices in complex environments. - Source: PubMed
Publication date: 2026/09/08
Xu JikangWang JiachengLi ZiyeSun WeidongWang JianlinLu QiangLiu WenjingLiu XiaoyangSun YanYan Xiaobing - Molecular antiferroelectrics (AFEs) with antiparallel dipole alignment are promising for energy-storage capacitor applications. However, it is challenging to design new molecular AFEs with superior breakdown resistance, owing to the lack of knowledge on the atomic-level origin regarding AFE orders. Here, we present stable breakdown resistance in 2D perovskite AFE, (2‑MBA)CsPbBr (2‑MBA = 2‑methylbutylammonium), involved with the confinement-dependent atomic displacement. It shows antiferroelectricity with a large spontaneous polarization of 5.0 µC/cm. Particularly, the cage‑confined Cs cations display atomic displacement to create stable antifatigue merits, including high breakdown field up to 175 kV/cm and the fatigue endurance beyond ∼10 cycles, falling in the range of the highest level for molecular AFEs. Combination of energy barrier calculation and in situ solid-state NMR spectroscopy was used to reveal the crucial role of displacive dynamics. Contrary to order-disordering dynamics, it is the high energy barrier (E = 2.91 eV) of cage-confined Cs cation displacement that leads to the increase in Curie temperature (∼327 K) and forward coercive field (∼56.8 kV/cm). Such attributes allow for AFE switching under stronger external stimuli, thus endowing stable fatigue resistance even at higher breakdown fields. This work provides a feasible principle of delicately manipulating cage-confined dynamics to design new electric-ordered candidates. - Source: PubMed
Publication date: 2026/09/07
Li WenjingMa YuYan YayuLiu YiFan QingshunTang LiweiLi QiaohongFu XiaobinLuo JunhuaSun Zhihua