AMDHD1 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- AMDHD1 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb36030
- Product Quantity:
- 5
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- AMDHD1 antibody Polyclonal Antibodies Primary antibodies
Related genes to: AMDHD1 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- AMDHD1 NIH gene
- Name:
- amidohydrolase domain containing 1
- Previous symbol:
- -
- Synonyms:
- MGC35366
- Chromosome:
- 12q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-17
- Date modifiied:
- 2016-07-14
Related products to: AMDHD1 antibody Polyclonal Antibodies Primary antibodies
Related articles to: AMDHD1 antibody Polyclonal Antibodies Primary antibodies
- Porcine epidemic diarrhea virus (PEDV) infection leads to serious intestinal disease in piglets, often leading to high mortality rates and substantial economic losses. Understanding host-PEDV interactions is crucial for PEDV therapeutic strategies. N-methyladenosine (mA) methylation has been proven to play an important role in host antiviral immunity. However, transcriptome-wide profiling patterns and the biological functions of host mA methylation in response to PEDV infection remain incompletely understood. This study first observed significant upregulation of mA regulators (METTL3, FTO, WTAP, YTHDC1, and YTHDF2) in PEDV infection. Following transcriptome-wide mA methylation and gene expression profiling, this study identified 803 differentially methylated peaks with 674 differentially expressed mA-methylated genes and 345 differentially expressed genes (DEGs) after PEDV infection. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses indicated that these differentially methylated genes were enriched mainly in lysine degradation, histidine metabolism, and the ubiquitin-mediated proteolysis pathway, whereas these DEGs were enriched in negative regulation of viral genome replication, viral protein interaction with cytokines and cytokine receptors, nucleotide-binding oligomerization domain-like (NOD-like) receptor signaling, and immune response-related signaling pathways. Furthermore, the joint analysis of RNA sequencing (RNA-seq) and methylated RNA immunoprecipitation sequencing (MeRIP-seq) identified 16 differentially expressed genes with mA methylation ( and ), which were associated with immune response and metabolism. Taken together, the study results map the dynamic landscape of host mA methylation and demonstrate the functional enrichment of mA methylated genes during PEDV infection, thereby providing a theoretical framework for future research on the role of mA methylation in resistance to PEDV infection. - Source: PubMed
Publication date: 2026/05/18
Dong XiaZhang YueWang YingWang ChengZhou Ao - - Source: PubMed
Publication date: 2026/04/06
Li YuhuiChen RongxiMo HuiWu QiLi ZhunHe SaiqiZhou AijunYu ShuhuiDuan ChaohuiNi WenLi Jianming - Cerebral white matter hyperintensities (WMHs) on MRI are part of the spectrum of age-related brain vascular injury and are associated with increased risk of stroke and dementia. Genome-wide association studies (GWASs) conducted mostly in populations of European ancestry have identified several genetic loci. Although Hispanic/Latino adults have a greater burden of WMHs than their non-Hispanic White counterparts, they are vastly underrepresented in genetic studies. We sought to characterize the genetic architecture of WMHs in a Hispanic/Latino cohort by investigating the transferability of known WMH genetic loci and by leveraging Hispanic/Latino genetic diversity to map novel loci. - Source: PubMed
Publication date: 2025/10/02
Fornage MyriamXia RuiOrdonez AdrianaSofer TamarIsasi Carmen RLipton Richard BStickel Ariana MTarraf WassimGonzalez Hector MDecarli Charles S - Cholangiocarcinoma (CCA) is a malignant tumor of the digestive system, characterized by its aggressive behavior and the absence of effective therapeutic biomarkers. Although recent studies have implicated AMDHD1 in tumor formation, its role in CCA development has been insufficiently explored. We utilized multiple bioinformatic datasets alongside 108 clinical samples to examine AMDHD1 expression in CCA. Then, in vitro and in vivo experiments were conducted to assess its impact on tumor growth and metastasis. Furthermore, proteomic analysis and immunoprecipitation mass spectrometry were employed to identify the downstream effectors of AMDHD1. We discovered that AMDHD1 was down-regulated in CCA and this down-regulation was associated with adverse clinicopathological features and prognosis. We also demonstrated that overexpression of AMDHD1 hindered G1/S progression in the cell cycle and promoted apoptosis, thereby inhibiting tumor growth and metastasis. Mechanistically, we found that AMDHD1 operated in a TGF-β-dependent manner and the inhibition of TGF-β signaling abrogated the effect of AMDHD1 overexpression on CCA cells. Specifically, AMDHD1 inhibited the ubiquitination and degradation of the SMAD4 protein through binding to the MH2 domain and synergistically enhanced SMAD2/3 phosphorylation, which activated of TGF-β signaling pathway and resulted in the suppression of CCA cell proliferation and migration. Our study identifies AMDHD1 as a significant prognostic biomarker and a tumor suppressor in CCA. It underscores the pivotal role of the AMDHD1/TGF-β signaling pathway in the development and progression of CCA. - Source: PubMed
Publication date: 2024/08/14
Ma ZuyiSun JiaLi ZhenchongHuang ShanzhouLi Binglu - Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease. Metabolism-related genes significantly influence the onset and progression of the disease. Hence, it is necessary to screen metabolism-related biomarkers for the diagnosis and treatment of NAFLD patients. - Source: PubMed
Publication date: 2023/09/11
Jiang HuaHu YangZhang ZhiboChen XujiaGao Jianpeng