ACHE antibody Polyclonal Antibodies Primary antibodies
- Known as:
- ACHE (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb127622
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- ACHE antibody Polyclonal Antibodies Primary antibodies
Related genes to: ACHE antibody Polyclonal Antibodies Primary antibodies
- Gene:
- ACHE NIH gene
- Name:
- acetylcholinesterase (Cartwright blood group)
- Previous symbol:
- YT
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-02
- Date modifiied:
- 2019-04-23
Related products to: ACHE antibody Polyclonal Antibodies Primary antibodies
Related articles to: ACHE antibody Polyclonal Antibodies Primary antibodies
- Benzodiazepine (BZ) use concerns have escalated in the wake of the opioid crisis, including increased overdose risk from co-use of BZ and opioids. Research evidence to inform clinical management of this issue is currently lacking. - Source: PubMed
Publication date: 2026/06/08
Wolitzky-Taylor KateOtto MichaelMetts AllisonHanano MariaMooney Larissa J - Chronic alcohol use reduces GABAergic activity and neuroactive steroid levels, contributing to stress response dysregulation and heightened pain sensitivity in individuals with alcohol use disorder (AUD). Neuroactive steroid precursor pregnenolone (PREG) reduces stress- and cue-related craving and anxiety responses in individuals with AUD, but its effects on pain responses in AUD have not been assessed. Sixty treatment-seeking men and women with AUD in an 8-week randomized trial receiving placebo (PBO; = 21), 300 mg PREG/day ( = 21), or 500 mg PREG/day ( = 18) completed a 3-day script-guided imagery provocation in Week 2. Following exposure to stress (S), alcohol cue (C), and neutral (N) conditions (administered across three separate laboratory days in a counterbalanced order), participants provided self-reports of pain, craving, and anxiety before, immediately after, and at various time points following the provocation. Analyses utilized a mixed factorial design with medication as a between-subjects factor and imagery condition and time point as within-subjects factors. The 300-mg PREG group did not exhibit significant increases in stress- or cue-induced pain compared with neutral condition (S:N: = .705; C:N: = .705), whereas increases in stress-induced pain in PBO (S > N: = .009; C:N: = .152) and stress- and cue-induced pain in the 500-mg PREG group (S > N: < .001; C > N: = .002) were observed. Pain was associated with alcohol craving ( < .001) and anxiety ( < .001). A PREG treatment effect showed positive associations between pain and alcohol craving in the PREG groups (300 mg: < .001; 500 mg: < .001) but not PBO ( = .962) and positive associations between pain and anxiety in the 300-mg PREG group (300 mg: < .001) but not the PBO or 500-mg PREG groups (PBO: = .325; 500 mg: = .213). PREG dose specifically reduced stress-provoked pain responses and affected concurrent pain and craving and anxiety associations, warranting further examination of PREG effects on pain and alcohol use outcomes in AUD. (PsycInfo Database Record (c) 2026 APA, all rights reserved). - Source: PubMed
Publication date: 2026/06/08
Quinlan RileyGao HuazeSinha RajitaMilivojevic Verica - - Source: PubMed
Publication date: 2026/06/08
Lee JihaLevinson Justin BMakris Una E - Intraoperative electron radiotherapy (IOERT) can be applied during breast conserving surgery to treat invasive breast cancer. Tumor-infiltrating lymphocytes (TILs) are fundamental elements of the specific immunological response against tumor cells and have prognostic importance in many types of cancer. The aim of the study was to analyze the local recurrence rate, adverse effects, surrogate molecular subtype, and stromal percentage of TILs in patients with breast cancer treated with exclusive IOERT. - Source: PubMed
Publication date: 2026/06/08
Oses GClavell CGonzález-Farré BSanfeliu ELaplana MMartínez AMoreno SMeca GGomis ECarreras-Ballvé JMension ECebrecos ICaparrós XTarrats-Rosell JCases CHerreros AMollà M - This study aimed to achieve two primary objectives: (1) to evaluate the opioid-sparing effect of Surgical Pleth Index (SPI)-directed analgesia during surgery via a randomized controlled trial (RCT), and (2) to propose and preliminarily assess a novel dynamic metric, Threshold-based Time-Weighted SPI (Tb-TW-SPI), which integrates stimulus intensity and duration, for its predictive efficacy regarding postoperative moderate-to-severe pain. Employing an RCT combined with exploratory analysis, 61 patients undergoing elective laparoscopic gynecologic surgery were randomized into an SPI-directed analgesia group or a conventional analgesia group. The primary outcome was total intraoperative remifentanil consumption. Postoperatively, an exploratory analysis of the control group data evaluated the correlation between Tb-TW-SPI and Numeric Rating Scale (NRS) pain scores in the post-anesthesia care unit (PACU), calculating its predictive value for moderate-to-severe pain (NRS ≥ 4). Results: The SPI-directed group required significantly less intraoperative remifentanil than the conventional group [median (IQR): 5.84(5.02,6.62)vs. 6.96(5.81,8.19)µg/kg/h; P = 0.016]. Postoperative pain scores did not differ significantly between groups (P > 0.05). Exploratory analysis of the conventional analgesia group revealed that Tb-TW-SPI values were significantly higher in patients with moderate-to-severe postoperative pain (NRS ≥ 4) compared to those without (P = 0.0417).The area under the ROC curve for Tb-TW-SPI predicting this pain was 0.74 (95% CI: 0.52-0.96), with 67% sensitivity and 76% specificity at an optimal cutoff of 1210. This RCT suggests that SPI-directed analgesia can safely and moderately reduce intraoperative remifentanil consumption. Furthermore, the proposed Tb-TW-SPI metric, in this exploratory analysis, suggests potential for predicting postoperative pain, though this finding requires validation in larger cohorts with higher-frequency SPI sampling, offering a new direction for SPI interpretation. Large-scale, multicenter trials are warranted to validate the predictive utility of Tb-TW-SPI. Clinical Trial Registration, China Clinical Trial Registry: ChiCTR2400088444. - Source: PubMed
Publication date: 2026/06/08
Liu WeiLi YingLin RanKe MinLin QinLin WeiZheng ShuWang Xiangfeng