CLEC6A antibody Polyclonal Antibodies Primary antibodies
- Known as:
- CLEC6A (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb125588
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- CLEC6A antibody Polyclonal Antibodies Primary antibodies
Related genes to: CLEC6A antibody Polyclonal Antibodies Primary antibodies
- Gene:
- CLEC6A NIH gene
- Name:
- C-type lectin domain containing 6A
- Previous symbol:
- CLECSF10
- Synonyms:
- dectin-2
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-18
- Date modifiied:
- 2017-03-23
Related products to: CLEC6A antibody Polyclonal Antibodies Primary antibodies
Related articles to: CLEC6A antibody Polyclonal Antibodies Primary antibodies
- Identifying the genetic changes that shaped recent human adaptation depends on our ability to detect selection from genomic data. Summary statistics from haplotype scans have been widely used for that purpose, aggregating genetic signal over windows, though resolution is limited by linkage and their power may diminish as sweeps approach fixation, as in the case of the integrated haplotype score (iHS). Ancient DNA based scans recover signal by analysing time-series trajectories, but the majority of human populations fall outside the geographic range of any existing ancient DNA dataset. Pairwise coalescence times provide a way to complement statistics and can be applied to any modern cohort, yet computing them densely enough at cohort scale poses a computational challenge due to the quadratic growth in the number of haplotype pairs. We introduce gamma_smc_cu , a GPU implementation of the Gamma-SMC algorithm (Schweiger and Durbin, 2023) for pairwise time-to-the-most-recent-common-ancestor (TMRCA) inference. Applied to the 1000 Genomes Project (3,202 phased samples, corresponding to 6,404 haplotypes; 829,638 within-population pairs across 26 populations and five different continental ancestries; ∼10 per-site posterior evaluations), it yields a gene-level TMRCA landscape of 17,823 autosomal protein-coding genes after masking for segmental duplications. The scan recovers well-known sweeps ( ) and, combined with a depleted-to-enriched variant-class profile, resolves haplotype-block signals down to the gene level. Of seven case studies, two are developed in the main text - / (chr11q13.2; SAS+EUR) and / (chr6p21.1) - and the remaining five ( chr2q24/IBS, chr12q24/CDX, chr12q21/CHS, chr20q11/GIH, chr12p13/CDX) are presented in the Supplementary Information (SI). Notably, / is a shared out-of-Africa signal - ranked below the within-population 1% tail in 16 of 19 non-African 1000 Genomes panels that PopHumanScan and five landmark haplotype-based scans miss. A previous 10 kb-windowed-mean iHS scan dilutes the cluster of extreme sites packed inside the ∼5 kb gene bodies, while our own gene-level iHS independently recovers the locus in three South Asian panels (BEB, STU, ITU; top 0.4% genome-wide). We cross-validate the seven cases against the 9.7 million per-variant selection posteriors from a recent West-Eurasian ancient DNA scan. is detected concordantly ( ≈ 1.8% per generation). and reach detection threshold in flanking variants but not within their own gene bodies, while the / cluster falls below it. To calibrate novelty, we review the candidate landscape against an expanded eight-catalog set spanning curated haplotype scans, the largest current West-Eurasian ancient-DNA leads, and a recent 26-population iHS refinement; the vast majority of our loci overlap at least one prior entry, and only a handful - including / - remain unflagged. The contributions of this work are gene-level resolution, systematic ancient DNA cross-validation, and a reusable TMRCA landscape that complements aDNA panels. - Source: PubMed
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Korfmann KevinMathieson Sara - Spinal cord injury (SCI) is a debilitating neurological condition that results in severe motor, sensory, and autonomic dysfunction, imposing a considerable burden on affected individuals and healthcare systems. Neutrophil extracellular traps (NETs) have been increasingly implicated in inflammatory and immune responses; however, the roles of NETs-related genes (NRGs) in SCI remain poorly understood. This study aimed to investigate the involvement of NRGs in SCI pathophysiology and to identify NET-associated candidate genes of potential biological relevance. - Source: PubMed
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