LAMP2 mAb (GL2A7);human, mouse
- Known as:
- LAMP2 mAb (GL2A7);H. sapiens, mouse
- Catalog number:
- ASAVAM-EN003D
- Product Quantity:
- 50 µL
- Category:
- -
- Supplier:
- Other suppliers
- Gene target:
- LAMP2 mAb (GL2A7);human mouse
Related genes to: LAMP2 mAb (GL2A7);human, mouse
- Gene:
- LAMP2 NIH gene
- Name:
- lysosomal associated membrane protein 2
- Previous symbol:
- -
- Synonyms:
- CD107b
- Chromosome:
- Xq24
- Locus Type:
- gene with protein product
- Date approved:
- 1990-08-03
- Date modifiied:
- 2019-04-23
Related products to: LAMP2 mAb (GL2A7);human, mouse
Related articles to: LAMP2 mAb (GL2A7);human, mouse
- The endoplasmic reticulum (ER) is a hub for several essential functions, including lipid metabolism, macroautophagy/autophagy, and innate immune signaling. Excess ER generated during a stress response is degraded by a selective type of autophagy known as ERphagy/reticulophagy. A recent study provides a mechanism by which cholesterol levels regulate ERphagy, STING1 activation, and cholesterol biosynthesis. Elevated ER cholesterol levels suppress ERphagy by reducing RETREG1/FAM134B interactions with the autophagy-related protein MAP1LC3/LC3 and the lysosomal protein LAMP2. The study shows that cholesterol directly binds to RETREG1 and SCAP, facilitating the formation of the RETREG1-SCAP complex. Sequestration of RETREG1 in this manner prevents it from performing its ERphagy functions. Furthermore, RETREG1 also interacts with STING1 and is important for its activation in response to viral infections. SCAP-RETREG1 complex formation also reduces the STING1 response. Thus, this study links lipid metabolism, innate immunity, and autophagy, emphasizing a central role for cholesterol in these processes. - Source: PubMed
Publication date: 2026/06/19
Govind Chhabi KKlionsky Daniel J - Macadamia nuts are rich in a variety of nutrients and are prone to oxidative deterioration during storage and transportation. They contain a high level of monounsaturated fatty acids, whose composition may change during oxidation. In this study, we determined the oxidation indicators of macadamia nuts and the changes in the proportion of monounsaturated fatty acids. In addition, we demonstrated that POA intervention reduced excessive mitochondrial superoxide production, thereby alleviating oxidative stress and mitigating inflammation. The alleviation of inflammation was associated with reduced lysosomal damage, as evidenced by increased expression of and , decreased levels, and enhanced lysosomal biogenesis. assays further revealed that POA treatment increased expression while decreasing expression. Molecular docking analysis suggested that the interaction between POA and NRF2 may involve key residues including valine (VAL-418, VAL-512 and VAL-465). Overall, POA alleviated cell inflammation through the NRF2/TBK1 signaling pathway. This study provides insights into the anti-inflammatory mechanisms of POA, highlighting its potential as a therapeutic agent. - Source: PubMed
Publication date: 2026/06/17
Sun Wen-HuiLi Ya-ZhuanDai WenTan Chin-PingRong Xiao-SongXu Yong-Jiang - Supraventricular tachycardias (SVTs) are among the most common arrhythmias encountered in clinical practice and, despite generally low mortality, impose substantial morbidity and healthcare utilization. Clinical heterogeneity in age of onset, recurrence, symptom burden, and overlap with conduction disease or cardiomyopathy suggests underlying biological determinants, including inherited susceptibility. Over the past decade, advances in human genomics have expanded evidence from familial aggregation and rare syndromic disorders to population-scale genome-wide association studies (GWAS), but routine translation into SVT care remains limited. - Source: PubMed
Publication date: 2026/05/29
Esmailian AminAlasti Mohammad - Clear cell renal cell carcinoma (ccRCC), the most common and aggressive subtype of kidney cancer, exhibits strong metastatic potential. Alternative splicing (AS) represents a critical regulatory layer of gene expression, yet its dysregulation in ccRCC remains insufficiently characterized. ccRCC datasets from GEO were analyzed using DESeq2 for differential gene expression and AS profiling. Gene Ontology enrichment was performed for differentially expressed genes (DEGs) and differentially AS event genes (DASEGs). Findings were compared with TCGA-KIRC to identify shared and Chinese-specific DASEs. An expression regulatory network linking differentially expressed RNA-binding proteins (RBPs) to DASEGs was constructed to screen key AS-regulated genes. Functional roles of the candidate gene TLN1 were validated by molecular and cellular experiments. Analysis of GSE126964 identified 2,295 DEGs and 1,331 DASEs, both enriched in platelet activation and degranulation pathways. Intersecting DEGs and DASEGs yielded 153 key genes. Comparison with TCGA-KIRC revealed 281 Chinese-specific DASEGs, including ALDOA, TLN1, LAMP2, and CD63. The RBP-DASEG network highlighted ALDOA, TLN1, and LAMP2 as potential core regulators associated with platelet pathways. TLN1 was markedly overexpressed in ccRCC tissues and cell lines, and its knockdown significantly reduced proliferation, migration, and colony formation in vitro, supporting a pro-tumorigenic function. This study uncovers platelet-related AS dysregulation in ccRCC and identifies TLN1 as a promising biomarker and therapeutic target, offering new insights into ccRCC pathogenesis and treatment strategies. - Source: PubMed
Publication date: 2026/06/08
Xin XiaoleiZhang ZhengyingLan XinLi JuntingBai PeimingFang LinYan WeiLuo Guangcheng - Autophagy is an evolutionarily highly conserved process and plays an important role in cellular homeostasis and metabolism. In obesity and obesity-associated insulin resistance, both enhanced and suppressed autophagy have been observed in adipose tissues (AT). - Source: PubMed
Publication date: 2026/05/23
Islami EditaSchmid AndreasSteger DanielKöhler SebastianSchäffler AndreasKarrasch Thomas