CLUAP1 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- CLUAP1 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb101140
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- CLUAP1 antibody Polyclonal Antibodies Primary antibodies
Related genes to: CLUAP1 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- CLUAP1 NIH gene
- Name:
- clusterin associated protein 1
- Previous symbol:
- -
- Synonyms:
- FLJ13297, KIAA0643, FAP22, CFAP22, IFT38
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-09-16
- Date modifiied:
- 2015-09-11
Related products to: CLUAP1 antibody Polyclonal Antibodies Primary antibodies
Related articles to: CLUAP1 antibody Polyclonal Antibodies Primary antibodies
- Age-related alterations in muscle tissue morphology and function, as well as chronic pro-inflammatory conditions, contribute to the development of sarcopenia. To elucidate the multidimensional pathogenesis of sarcopenia, we performed a comprehensive genetic analysis, including common variants, rare variants, and human leukemia antigen (HLA). - Source: PubMed
Publication date: 2025/03/18
Furutani MotokiKimura TetsuakiFukunaga KoyaSuganuma MutsumiTakemura MarieMatsui YasumotoSatake ShosukeNakano YukikoMushiroda TaiseiNiida ShumpeiOzaki KouichiHosoyama TohruShigemizu Daichi - This study investigated how clinical and genetic factors impact the effectiveness of orthokeratology lenses in myopia. - Source: PubMed
Publication date: 2025/03/17
Xia RuijingYu XiangyiWu HaoPeng LuluDu ZhenlinYu XiaoguangXing ShilaiLu FanMao Xinjie - The scenario of the fertile spermatozoa with high fertilizing capability is basically dependent on gene expression-based epididymal function. The current investigation aimed to declare the varied expression of different candidate genes (PLA2G4D, LCN15, CLUAP1, SPP1, AQP12B, DEFB110 and ESR1) relevant to spermatozoa features between the different epididymal segments in the mature dromedary camels (n = 30). Scrotal contents were collected post-slaughtering, during the breeding season and the epididymis was separated from the testicles and divided into three segments (caput, corpus and cauda) based on its morphology and anatomical characteristics. Epididymal spermatozoa were harvested from each epididymal portion and evaluated for motility, count, viability and morphology. Samples were grouped depending on their epididymal sperm cells features into high-fertile (n = 15) and low-fertile (n = 15) groups. The gene expression of the candidate genes was defined in the isolated RNA from each epididymal portion tissue. The segmental sperm motion and count were significantly (p < .05 and p < .01) higher in the three epididymal parts of high-fertile camels than the lower ones. There were some candidate genes markedly up-regulated in its expression in epididymal head of high-fertile camels (PLA2G4D and LCN15) and low fertile (CLUAP1), while others in the body region of the high-fertile group (SPP1, AQP12B and DEFB110). Nevertheless, ER1 did not differ in the expression among the epididymal segments. In conclusion, the variant expression patterns of these epididymal genes in relation to the regional spermatozoa features might suggest important roles of these genes in sperm maturation process in the epididymis and focusing more interest on their potential utility as markers for male camel fertility prediction. - Source: PubMed
Rashad Dina E MIbrahim SallyEl-Sokary Mohamed M MMahmoud Karima Gh MKandiel Mohamed M MAbou El-Roos Mahmoud E ASosa Gamal A M - Studying testicular genes' expression may give key insights into precise regulation of its functions that influence epididymal sperm quality. The current study aimed to investigate the abundance of candidate genes involved in the regulation of testicular functions specially those regulate sperm function (PLA2G4D, SPP1, and CLUAP1), testicular steroidogenic function (ESR1 and AR), materials transport (AQP12B and LCN15), and defense mechanisms (DEFB110, GPX5, SOCS3, and IL6). Therefore, blood samples and testes with epididymis were collected from mature middle-aged (5-10 years) dromedary camels (n = 45) directly prior and after their slaughtering, respectively, during breeding season. Sera were evaluated for testosterone level and testicular biometry was measured with caliper. The epididymal tail semen was evaluated manually. Samples were distinguished based on testosterone level, testicular biometry, as well as epididymal semen features into high and low fertile groups. Total RNA was isolated from testicular tissues and gene expression was done using Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). Results revealed that testosterone levels were significantly (P < 0.005) higher in camels with good semen quality than those of low quality. There was a significant (P < 0.0001) increase in testicular weight, length, width, thickness, and volume in high fertile than low fertile camels. PLA2G4D, SPP1, CLUAP1, ESR1, AR, AQP12B, LCN15, DEFB110, GPX5, and SOCS3 genes were upregulated (P < 0.001), and IL6 gene was downregulated (P < 0.01) in the testes of high fertile camels compared to the low fertile one. Thus, it could be concluded that examined genes might be valuable monitors of testicular functional status and fertility in dromedary camels. - Source: PubMed
Rashad Dina E MIbrahim SallyEl-Sokary Mohamed M MMahmoud Karima Gh MAbou El-Roos Mahmoud E ASosa Gamal A MKandiel Mohamed M M - Primary cilia are essential cellular antennae that transmit external signals into intracellular responses. These sensory organelles perform crucial tasks in triggering intracellular signaling pathways, including those initiated by G protein-coupled receptors (GPCRs). Given the involvement of GPCRs in serum-induced signaling, we investigated the contribution of ciliary proteins in mitogen perception and cell proliferation. We found that depletion of cilia via IFT88 silencing impaired cell growth and repressed YAP activation against serum and its mitogenic constituents, namely lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). To identify the key player of serum mitogen signaling, a mutant cell line library with 30 ablated individual ciliary proteins was established and screened based on YAP dephosphorylation and target gene induction. While 9 of them had altered signaling, ablation of IFT38 or IFT144 led to a particularly robust repression of YAP activation upon LPA and S1P. The deficiency of IFT38 and IFT144 attenuated cell proliferation, as corroborated in either 2-dimensional cultures or tumor spheroids. In subcutaneous skin melanoma patients, expression of IFT38 and IFT144 was associated with unfavorable outcomes in overall survival. In conclusion, our study demonstrates the involvement of ciliary proteins in mitogen signaling and identifies the regulatory roles of IFT38 and IFT144 in serum-mediated Hippo pathway signaling and cellular growth. - Source: PubMed
Publication date: 2023/09/27
Yu Jae-HyunKim Jeong HeonSoung Nak-KyunMoon Eun-YiKoo Ja Hyun