KCNK antibody Polyclonal Antibodies Primary antibodies
- Known as:
- KCNK (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100692
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- KCNK antibody Polyclonal Antibodies Primary antibodies
Related genes to: KCNK antibody Polyclonal Antibodies Primary antibodies
- Gene:
- KCNK15 NIH gene
- Name:
- potassium two pore domain channel subfamily K member 15
- Previous symbol:
- KCNK11, KCNK14
- Synonyms:
- K2p15.1, dJ781B1.1, KT3.3, KIAA0237, TASK5, TASK-5
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-15
- Date modifiied:
- 2016-02-04
Related products to: KCNK antibody Polyclonal Antibodies Primary antibodies
Related articles to: KCNK antibody Polyclonal Antibodies Primary antibodies
- Rising global temperatures lead to a continuous increase in the frequency and intensity of extreme weather events, such as droughts and floods, posing serious threats to terrestrial homeotherms. However, adaptive changes in respiratory metabolism and molecular mechanisms in lung tissues of small mammals under extreme water shortage conditions remain unclear. This study hypothesized that small desert mammals can adapt to extreme water shortage environments by regulating the plasticity of lung tissue gene expression and respiratory metabolism. Using 29 wild-caught Siberian jerboas () as subjects, we implemented a 12-day complete water deprivation protocol to simulate extreme aridity. Body weight, food intake, and daily energy expenditure (DEE) were monitored throughout the experiment. Whole-transcriptome sequencing of lung tissues was performed to profile mRNA, circRNA, and miRNA expression, with competitive endogenous RNA (ceRNA) network analysis to explore molecular mechanisms underlying lung adaptation to water deprivation. Over the 12-day water deprivation (WS) period, exhibited a 30.3% reduction in body mass and a 68.1% decrease in food intake relative to the baseline level. DEE during the peak activity period at the end of the experiment was 12.6% lower in the WS group compared to the control group. In lung tissue, structural integrity-related genes (, ) were downregulated. A key finding was that exhibits a significant positive correlation with the potassium channel gene and a robust negative correlation with -suggesting that functions as a competing endogenous RNA (ceRNA) to sequester and thereby derepress expression. Core regulatory genes (, etc.) were also coordinately downregulated. Collectively, these results indicate that reduces overall energy expenditure, which may be associated with lung gene expression plasticity, such as those related with lung cell proliferation, pulmonary function, and gas exchange efficiency. This metabolic downregulation facilitates energy conservation under severe water scarcity. - Source: PubMed
Publication date: 2026/02/01
Jin YonglingZhang RongLi XinLi LinlinZhang DongLing YuYuan ShuaiZhang XueyingFu HepingWu Xiaodong - We identified new diagnostic markers for ovarian cancer based on the analysis of aberrant methylation in a group of long non-coding RNA (lncRNA) genes. Using quantitative methyl-specific PCR with the nonparametric Mann-Whitney test, a significant (p < 0.01) increase in the methylation levels of three lncRNA genes (KCNK15-AS1, MAGI2-AS3, SSTR5-AS1) was demonstrated in a representative cohort of 56 clinical ovarian cancer samples. Using quantitative reverse transcription PCR on the same sample set, a significant decrease in the expression of these three lncRNA genes (p < 0.01) and a statistically significant inverse correlation between changes in methylation and expression levels (r < -0.5) were demonstrated, which confirms the functional role of methylation in suppressing their expression in tumor tissues. ROC analysis was used to assess the diagnostic potential of these genes. It was shown that the detection of methylation in at least one of the three genes in tissue DNA samples allows for identification of ovarian cancer with 98% sensitivity and 100% specificity (test > 0, AUC = 0.989). The developed marker panel may be of interest for the molecular assessment of at-risk patients when determining a preliminary diagnosis. However, the method requires validation on a larger, more representative sample set. - Source: PubMed
Publication date: 2025/09/29
Lukina S SBurdenyy A MFilippova E ALoginov V IPronina I VIvanova N ASelezneva Al DSelezneva An DArzhanukhina N AKazubskaya T PKushlinskii N EBraga E A - Cancer-associated hypersialylation is believed to be related to the metastatic cell phenotype and the suppression of sialyltransferases (SiaTs) has been suggested to be a potent preventive strategy against metastasis. The present research discovered SiaTs-related genes for cervical cancer (CC). - Source: PubMed
Publication date: 2025/05/22
Shao JiaZhang CanTang YaonanHe AiqinCheng Xiangyan - Our work aimed to evaluate and differentiate the role of ten lncRNA genes (, , , , , , , , , and ) in the development and progression of epithelial ovarian cancer (EOC). A representative set of clinical samples was used: 140 primary tumors from patients without and with metastases and 59 peritoneal metastases. Using MS-qPCR, we demonstrated an increase in methylation levels of all ten lncRNA genes in tumors compared to normal tissues ( < 0.001). Using RT-qPCR, we showed downregulation and an inverse relationship between methylation and expression levels for ten lncRNAs ( < -0.5). We further identified lncRNA genes that were specifically hypermethylated in tumors from patients with metastases to lymph nodes (), peritoneum (, , and ), and greater omentum (, , and ). The same four lncRNA genes involved in peritoneal spread were associated with clinical stage and tumor extent ( < 0.001). Interestingly, we found a reversion from increase to decrease in the hypermethylation level of five metastasis-related lncRNA genes (, , , , and ) in 59 peritoneal metastases. This reversion may be associated with partial epithelial-mesenchymal transition (EMT) in metastatic cells, as indicated by a decrease in the level of the EMT marker, CDH1 mRNA ( < 0.01). Furthermore, novel mRNA targets and regulated miRNAs were predicted for a number of the studied lncRNAs using the NCBI GEO datasets and analyzed by RT-qPCR and transfection of SKOV3 and OVCAR3 cells. In addition, hypermethylation of , , and genes was proposed as a marker for overall survival in patients with EOC. - Source: PubMed
Publication date: 2024/11/04
Braga Eleonora ABurdennyy Alexey MUroshlev Leonid AZaichenko Danila MFilippova Elena ALukina Svetlana SPronina Irina VAstafeva Iana RFridman Marina VKazubskaya Tatiana PLoginov Vitaly IDmitriev Alexey AMoskovtsev Aleksey AKushlinskii Nikolay E - TASK-5 (KCNK15) belongs to the acid-sensitive subfamily of two-pore domain potassium (K) channels, which includes TASK-1 and TASK-3. TASK-5 stands out as K channel for which there is no functional data available, since it was reported in 2001 as non-functional and thus "silent". Here we show that TASK-5 channels are indeed non-functional as homodimers, but are involved in the formation of functional channel complexes with TASK-1 and TASK-3. TASK-5 negatively modulates the surface expression of TASK channels, while the heteromeric TASK-5-containing channel complexes located at the plasma membrane are characterized by changes in single-channel conductance, Gq-coupled receptor-mediated channel inhibition, and sensitivity to TASK modulators. The unique pharmacology of TASK-1/TASK-5 heterodimers, affected by a common polymorphism in KCNK15, needs to be carefully considered in the future development of drugs targeting TASK channels. Our observations provide an access to study TASK-5 at the functional level, particularly in malignant cancers associated with KCNK15. - Source: PubMed
Publication date: 2024/08/30
Rinné SusanneSchick FlorianVowinkel KirstySchütte SvenKrasel CorneliusKauferstein SilkeSchäfer Martin K-HKiper Aytug KMüller ThomasDecher Niels