FGF6 antibody Polyclonal Antibodies Primary antibodies
- Known as:
- FGF6 (anti-) Polyclonal Antibodies Primary antibodies
- Catalog number:
- orb100691
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- FGF6 antibody Polyclonal Antibodies Primary antibodies
Related genes to: FGF6 antibody Polyclonal Antibodies Primary antibodies
- Gene:
- FGF6 NIH gene
- Name:
- fibroblast growth factor 6
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12p13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1990-02-24
- Date modifiied:
- 2016-10-05
Related products to: FGF6 antibody Polyclonal Antibodies Primary antibodies
Related articles to: FGF6 antibody Polyclonal Antibodies Primary antibodies
- Nestin-expressing stem cells located in the bulge area of the hair follicle can give rise to multiple cell types. In the present study, we subcutaneously transplanted red fluorescent protein (RFP)-labeled SK-MEL-5 human melanoma cells into nestin-driven green fluorescent protein (ND-GFP)-nude mice. Nestin-GFP-positive cells differentiated into CD31-positive endothelial cells and αSMA-positive pericytes, and βIII-tubulin-positive neurons, forming blood vessel-like and nerve-like structures within the transplanted melanoma. Bevacizumab, a vascular endothelial growth factor (VEGF)-targeting monoclonal antibody, suppressed nestin-positive blood-vessel structures and nerve structures from forming within the tumor but did not significantly inhibit tumor growth. Due to bevacizumab treatment, blood-vessel-like and nerve-like structures expressing CD31, αSMA, and βIII tubulin formed without the expression of nestin in the transplanted melanoma but remained RFP-positive, suggesting that they trans-differentiated from melanoma cells. Relative mRNA expression of VEGFA also significantly decreased in the melanoma after bevacizumab treatment of the mice. In contrast, VEGFR2 and FGF6, markers that are related to blood vessels, significantly increased compared with the non-treated mice. In the bevacizumab-treated mice, mRNA expression of Tuj1, BDNF, and IGF1 markers related to nerves significantly increased within the melanoma. In the bevacizumab-treated mice, nestin expression was not detected, but RFP was maintained in the blood-vessel-like and nerve-like structures in the melanoma. Since nestin was not detected and RFP was maintained, it suggests these structures trans-differentiated from the melanoma cells. The present study suggests that both the host and cancer cells can differentiate into blood-vessel-like and nerve-like structures in the melanoma. - Source: PubMed
Publication date: 2026/08/03
Obara KoyaSasaki AzusaHamada YukoKubota YutaroAoki YusukeMasaki NoriyukiBouvet MichaelAmoh YasuyukiHoffman Robert M - The composition of fatty acids, particularly the content of unsaturated fatty acids (UFA), is closely related to meat quality and flavor in ducks. - Source: PubMed
Publication date: 2026/05/07
Feng YulongXu MengruLi MeijuanLu YuxiDai GuotaoTian ChengchengZhao YuLiu HeheHuang Anqi - Acute liver injury (ALI) requires rapid hepatic regeneration to avert fatal liver failure. As key mechanisms, systemic metabolic remodeling and inter-organ crosstalk are critical for this regenerative process. Skeletal muscle, as a major metabolic organ system, undergoes significant remodeling during ALI. However, its specific regulatory contributions remain largely uncharacterized. - Source: PubMed
Publication date: 2025/07/21
Xu Yue-JieLiu Cai-ZhiChen YingLi Lan-XinXu BoYou Ling-XinMeng Mei-YaoLi XinZhang HongDing Qiu-RongZhang RongMa Xin-RanChen Xiao-HuaHu Cheng - Almost 90 % of head and neck malignancies are malignant squamous cell cancers, making it the sixth most common malignancy in the developing countries, with an overall five-year overall survival rate about 40 %-50 %. Early diagnosis and treatment can bring a better prognosis. Fibroblast growth factor (FGF) is an important polypeptide in vivo. Studies have found that FGF signal has carcinogenic potential and participates in a variety of carcinogenic behaviors. Some experiments have proved that FGF signal has the function of tumor inhibition in some cases, and the role of FGF signalling in tissue repair and homeostasis suggest a role for FGF in targeted therapy and prognosis. However, its manifestation and predictive role in HNSC have not been clearly defined. - Source: PubMed
Publication date: 2025/03/12
Zhang LiGao YingchunTian YumeiWei JianXu YingjiaoZhang XuanNie MinhaiLiu Xuqian - - Source: PubMed
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